Structural features of an exocyclic adduct positioned opposite an abasic site in a DNA duplex

Biochemistry ◽  
1991 ◽  
Vol 30 (13) ◽  
pp. 3262-3270 ◽  
Author(s):  
Michael Kouchakdjian ◽  
Moises Eisenberg ◽  
Francis Johnson ◽  
Arthur P. Grollman ◽  
Dinshaw J. Patel
Keyword(s):  
Structural Features ◽  
Abasic Site ◽  
Dna Duplex

Search for DNA Repair Inhibitors:  Selective Binding of Nucleic Bases−Acridine Conjugates to a DNA Duplex Containing an Abasic Site†

1997 ◽  
Vol 40 (21) ◽  
pp. 3346-3352 ◽  
Author(s):  
Nathalie Berthet ◽  
Jean-François Constant ◽  
Martine Demeunynck ◽  
Pierre Michon ◽  
Jean Lhomme
Keyword(s):  
Dna Repair ◽  
Abasic Site ◽  
Dna Duplex ◽  
Selective Binding ◽  
Nucleic Bases ◽  
Dna Repair Inhibitors

Competitive Assay for Theophylline Based on an Abasic Site-Containing DNA Duplex Aptamer and a Fluorescent Ligand

2012 ◽  
Vol 18 (40) ◽  
pp. 12719-12724 ◽  
Author(s):  
Yusuke Sato ◽  
Yushuang Zhang ◽  
Seiichi Nishizawa ◽  
Takehiro Seino ◽  
Kodai Nakamura ◽  
...  
Keyword(s):  
Abasic Site ◽  
Dna Duplex ◽  
Competitive Assay ◽  
Fluorescent Ligand

Intercalation of antitumor drug doxorubicin and its analogue by DNA duplex: Structural features and biological implications

2014 ◽  
Vol 66 ◽  
pp. 144-150 ◽  
Author(s):  
Daniel Agudelo ◽  
Philippe Bourassa ◽  
Gervais Bérubé ◽  
Heidar-Ali Tajmir-Riahi
Keyword(s):  
Structural Features ◽  
Antitumor Drug ◽  
Dna Duplex

Specific Recognition and Stabilization of an Abasic Site-Containing DNA Duplex by a Macrocyclic Bisacridine

1999 ◽  
Vol 18 (6-7) ◽  
pp. 1351-1353 ◽  
Author(s):  
M. P. Teulade-Fichou ◽  
J. P. Vigneron ◽  
J. M. Lehn ◽  
N. Berthet ◽  
J. Michon ◽  
...  
Keyword(s):  
Abasic Site ◽  
Dna Duplex ◽  
Specific Recognition

Nitroxides and nucleic acids: Chemistry and electron paramagnetic resonance (EPR) spectroscopy

2011 ◽  
Vol 83 (3) ◽  
pp. 677-686 ◽  
Author(s):  
Snorri Th. Sigurdsson
Keyword(s):  
Electron Paramagnetic Resonance ◽  
Nucleic Acids ◽  
Epr Spectroscopy ◽  
Noncovalent Interactions ◽  
Spin Labeling ◽  
Structural Features ◽  
Spin Labels ◽  
Abasic Site ◽  
Paramagnetic Resonance ◽  
Electron Paramagnetic

Electron paramagnetic resonance (EPR) spectroscopy has increasingly been applied for the study of nucleic acid structure and dynamics. Such studies require incorporation of free radicals (spin labels) into the biopolymer. The labels can be incorporated during chemical synthesis of the oligomer (phosphoramidite approach) or postsynthetically, by reaction of a spin-labeling reagent with a reactive functional group on the oligonucleotide. Incorporation of the rigid nitroxide spin label Ç is an example of the phosphoramidite method, and reaction of a spin-labeled azide with an alkyne-modified oligomer to yield a triazole-derived, spin-labeled nucleotide illustrates the postsynthetic spin-labeling strategy. Characterization and application of these labels to study structural features of DNA by EPR spectroscopy is discussed. Finally, a new spin-labeling strategy is described for nucleic acids that relies on noncovalent interactions between a spin-labeled nucleobase and an abasic site in duplex DNA.

Interaction of a Spin-Labeled Adenine−Acridine Conjugate with a DNA Duplex Containing an Abasic Site Model†

Biochemistry ◽  
1999 ◽  
Vol 38 (6) ◽  
pp. 1930-1937 ◽  
Author(s):  
Fabrice Thomas ◽  
Josette Michon ◽  
Jean Lhomme
Keyword(s):  
Abasic Site ◽  
Dna Duplex ◽  
Site Model

Targeting abasic site-containing DNA with annelated quinolizinium derivatives: the influence of size, shape and substituents

2014 ◽  
Vol 12 (11) ◽  
pp. 1725-1734 ◽  
Author(s):  
Katja Benner ◽  
Heiko Ihmels ◽  
Sarah Kölsch ◽  
Phil M. Pithan
Keyword(s):  
Comparative Analysis ◽  
Structural Features ◽  
Abasic Site

A comparative analysis showed that the type and degree of annelation as well as methyl or chloro-substitution are relevant structural features that determine the interactions of quinolizinium derivatives with abasic site-containing DNA.

NMR and Molecular Modeling Studies of the Interaction of Artificial AP Lyases with a DNA Duplex Containing an Apurinic Abasic Site Model†

Biochemistry ◽  
1997 ◽  
Vol 36 (16) ◽  
pp. 4831-4843 ◽  
Author(s):  
Yannick Coppel ◽  
Jean-François Constant ◽  
Christian Coulombeau ◽  
Martine Demeunynck ◽  
Julian Garcia ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Abasic Site ◽  
Dna Duplex ◽  
Site Model ◽  
Modeling Studies ◽  
Molecular Modeling Studies

Enhancement in fluorescence response by a quencher for amiloride upon binding to thymine opposite an abasic site in a DNA duplex

2010 ◽  
Vol 675 (1) ◽  
pp. 49-52 ◽  
Author(s):  
Yusuke Sato ◽  
Jing Tian ◽  
Toshiki Ichihashi ◽  
Yuka Chinda ◽  
Zhiai Xu ◽  
...  
Keyword(s):  
Abasic Site ◽  
Dna Duplex ◽  
Fluorescence Response
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