Lens Major Intrinsic Protein (MIP) Promotes Adhesion When Reconstituted into Large Unilamellar Liposomes

Biochemistry ◽  
1994 ◽  
Vol 33 (24) ◽  
pp. 7663-7669 ◽  
Author(s):  
Luis F. Michea ◽  
Milton de la Fuente ◽  
Nestor Lagos
Keyword(s):  
Major Intrinsic Protein ◽  
Intrinsic Protein

Genome-wide Characterization of Major Intrinsic Protein (MIP) Gene Family in Brachypodium distachyon

2018 ◽  
Vol 13 (5) ◽  
pp. 536-552 ◽  
Author(s):  
Ankush Ashok Saddhe ◽  
Shweta ◽  
Kareem A. Mosa ◽  
Kundan Kumar ◽  
Manoj Prasad ◽  
...  
Keyword(s):  
Gene Family ◽  
Brachypodium Distachyon ◽  
Major Intrinsic Protein ◽  
Intrinsic Protein ◽  
Genome Wide

scholarly journals Lens Major Intrinsic Protein (MIP)/Aquaporin 0 Expression in Rat Lens Epithelia Explants Requires Fibroblast Growth Factor-induced ERK and JNK Signaling

2004 ◽  
Vol 279 (30) ◽  
pp. 31813-31822 ◽  
Author(s):  
Nady Golestaneh ◽  
Jianguo Fan ◽  
Robert N. Fariss ◽  
Woo-Kuen Lo ◽  
Peggy S. Zelenka ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Major Intrinsic Protein ◽  
Jnk Signaling ◽  
Intrinsic Protein

A Novel Missense Mutation in the Gene Encoding Major Intrinsic Protein (MIP) in a Giant Panda with Unilateral Cataract Formation

2020 ◽  
Author(s):  
Chao Bai ◽  
Yuyan You ◽  
Xuefeng Liu ◽  
Maohua Xia ◽  
Wei Wang ◽  
...  
Keyword(s):  
Missense Mutation ◽  
Conformational Changes ◽  
Giant Panda ◽  
Ailuropoda Melanoleuca ◽  
Major Intrinsic Protein ◽  
Gene Encoding ◽  
Functional Candidate Gene ◽  
Intrinsic Protein ◽  
Age Related ◽  
Unilateral Cataract

Abstract Background: Cataracts are defects of the lens that cause progressive visual impairment and ultimately blindness in many vertebrate species. Most cataracts are age-related, but up to one third have an underlying genetic cause. Cataracts are common in captive zoo animals, but it is often unclear whether these are congenital or acquired (age-related) lesions. Results: Here we used a functional candidate gene screening approach to identify mutations associated with cataracts in a captive giant panda (Ailuropoda melanoleuca). We screened 11 genes often associated with human cataracts and identified a novel missense mutation (c.686G>A) in the MIP gene encoding major intrinsic protein. This is expressed in the lens and normally accumulates in the plasma membrane of lens fiber cells, where it plays an important role in fluid transport and cell adhesion. The mutation causes the replacement of serine with asparagine (p.S229N) in the C-terminal tail of the protein, and modeling predicts that the mutation induces conformational changes that may interfere with lens permeability and cell–cell interactions.Conclusion: The c.686G>A mutation was found in a captive giant panda with a unilateral cataract but not in 18 controls from diverse regions in China, suggesting it is most likely a genuine disease-associated mutation rather than a single-nucleotide polymorphism. The mutation could therefore serve as a new genetic marker to predict the risk of congenital cataracts in captive giant pandas.

scholarly journals The Arabidopsis Major Intrinsic Protein NIP5;1 Is Essential for Efficient Boron Uptake and Plant Development under Boron Limitation

2006 ◽  
Vol 18 (6) ◽  
pp. 1498-1509 ◽  
Author(s):  
Junpei Takano ◽  
Motoko Wada ◽  
Uwe Ludewig ◽  
Gabriel Schaaf ◽  
Nicolaus von Wirén ◽  
...  
Keyword(s):  
Plant Development ◽  
Boron Uptake ◽  
Major Intrinsic Protein ◽  
Intrinsic Protein

The cDNA sequence encoding the major intrinsic protein of frog lens

Gene ◽  
1993 ◽  
Vol 124 (2) ◽  
pp. 303-304 ◽  
Author(s):  
LeeAnn R. Austin ◽  
Stephen J. Rice ◽  
George J. Baldo ◽  
Alex J. Lange ◽  
Howard C. Haspel ◽  
...  
Keyword(s):  
Cdna Sequence ◽  
Major Intrinsic Protein ◽  
Intrinsic Protein ◽  
Sequence Encoding
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