Tremorgenic Indole Alkaloids Potently Inhibit Smooth Muscle High-Conductance Calcium-Activated Potassium Channels

Biochemistry ◽  
1994 ◽  
Vol 33 (19) ◽  
pp. 5819-5828 ◽  
Author(s):  
Hans-Guenther Knaus ◽  
Owen B. McManus ◽  
Seok H. Lee ◽  
William A. Schmalhofer ◽  
Margarita Garcia-Calvo ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Potassium Channels ◽  
Indole Alkaloids ◽  
Calcium Activated Potassium Channels ◽  
High Conductance

Selective, Direct Activation of High-Conductance, Calcium-Activated Potassium Channels Causes Smooth Muscle Relaxation

2012 ◽  
Vol 81 (4) ◽  
pp. 567-577 ◽  
Author(s):  
Cristiano G. Ponte ◽  
Owen B. McManus ◽  
William A. Schmalhofer ◽  
Dong-Ming Shen ◽  
Ge Dai ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Potassium Channels ◽  
Muscle Relaxation ◽  
Smooth Muscle Relaxation ◽  
Direct Activation ◽  
Calcium Activated Potassium Channels ◽  
High Conductance

[125I]Iberiotoxin-D19Y/Y36F, the First Selective, High Specific Activity Radioligand for High-Conductance Calcium-Activated Potassium Channels

Biochemistry ◽  
1997 ◽  
Vol 36 (7) ◽  
pp. 1943-1952 ◽  
Author(s):  
Alexandra Koschak ◽  
Robert O. Koch ◽  
Jessica Liu ◽  
Gregory J. Kaczorowski ◽  
Peter H. Reinhart ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Specific Activity ◽  
High Specific Activity ◽  
Calcium Activated Potassium Channels ◽  
High Conductance

scholarly journals Calcium-Activated Potassium Channels and the Regulation of Vascular Tone

Physiology ◽  
2006 ◽  
Vol 21 (1) ◽  
pp. 69-78 ◽  
Author(s):  
Jonathan Ledoux ◽  
Matthias E. Werner ◽  
Joseph E. Brayden ◽  
Mark T. Nelson
Keyword(s):  
Smooth Muscle ◽  
Potassium Channels ◽  
Vascular Function ◽  
Vascular Tone ◽  
Calcium Signals ◽  
Different Types ◽  
Calcium Activated Potassium Channels ◽  
Regulation Of Vascular Tone

Different calcium signals in the endothelium and smooth muscle target different types of Ca2+-sensitive K+ channels to modulate vascular function. These differential calcium signals and targets represent multilayered opportunities for prevention and/or treatment of vascular dysfunctions.

High-conductance calcium-activated potassium channels; Structure, pharmacology, and function

1996 ◽  
Vol 28 (3) ◽  
pp. 255-267 ◽  
Author(s):  
Gregory J. Kaczorowski ◽  
Hans -Günther Knaus ◽  
Reid J. Leonard ◽  
Owen B. McManus ◽  
Maria L. Garcia
Keyword(s):  
Potassium Channels ◽  
Calcium Activated Potassium Channels ◽  
And Function ◽  
High Conductance
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