High-conductance calcium-activated potassium channels; Structure, pharmacology, and function

1996 ◽  
Vol 28 (3) ◽  
pp. 255-267 ◽  
Author(s):  
Gregory J. Kaczorowski ◽  
Hans -Günther Knaus ◽  
Reid J. Leonard ◽  
Owen B. McManus ◽  
Maria L. Garcia
Keyword(s):  
Potassium Channels ◽  
Calcium Activated Potassium Channels ◽  
And Function ◽  
High Conductance

[125I]Iberiotoxin-D19Y/Y36F, the First Selective, High Specific Activity Radioligand for High-Conductance Calcium-Activated Potassium Channels

Biochemistry ◽  
1997 ◽  
Vol 36 (7) ◽  
pp. 1943-1952 ◽  
Author(s):  
Alexandra Koschak ◽  
Robert O. Koch ◽  
Jessica Liu ◽  
Gregory J. Kaczorowski ◽  
Peter H. Reinhart ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Specific Activity ◽  
High Specific Activity ◽  
Calcium Activated Potassium Channels ◽  
High Conductance

Parathyroid hormone-related protein-mediated responses in pulmonary arteries and veins of newborn lambs

2005 ◽  
Vol 289 (1) ◽  
pp. L60-L66 ◽  
Author(s):  
Yuansheng Gao ◽  
J. Usha Raj
Keyword(s):  
Potassium Channels ◽  
Pulmonary Arteries ◽  
Phosphodiesterase Inhibitor ◽  
Intracellular Camp ◽  
Camp Content ◽  
Parathyroid Hormone Related Protein ◽  
Voltage Dependent ◽  
Calcium Activated Potassium Channels ◽  
And Function ◽  
Arteries And Veins

PTHrP has important roles in lung development and function. Here we determined the vasomotor responses of isolated pulmonary arteries and veins of newborn and adult sheep to PTHrP. In vessels constricted with endothelin-1, PTHrP (PTHrP 1-34) caused greater relaxation of veins than of arteries. In both vessel types, relaxation to the peptide was less in adult than in newborn vessels. In newborn lambs, PTHrP-induced relaxation was not affected by endothelium removal, inhibition of eNOS, or inhibition of adenylyl cyclases by SQ-22536. However, relaxation was attenuated by 4-aminopyridine, inhibitor of voltage-dependent potassium channels, in both arteries and veins, and by charybdotoxin, inhibitor of calcium-activated potassium channels, in veins. When vessels were saturated with 8-BrcAMP (3 × 10−4 M), to eliminate relaxation mediated by endogenous cAMP, PTHrP-induced relaxation was partially attenuated. In vessels treated with 8-BrcAMP (3 × 10−4 M), 4-aminopyridine but not charybdotoxin inhibited relaxation induced by PTHrP 1-34 in both arteries and veins. Radioimmunoassay showed that, in the presence of a general phosphodiesterase inhibitor, PTHrP caused a concentration-dependent increase in intracellular cAMP content in arteries and veins, which was largely abolished by SQ-22536. Our results demonstrate that PTHrP is a potent vasodilator of pulmonary vessels, with a greater effect in veins than in arteries. Relaxation induced by the peptide contains both cAMP-dependent and -independent components. In both arteries and veins, voltage-dependent potassium channels mediate the response to PTHrP, at least in part, in a cAMP-independent fashion; and in veins, calcium-activated potassium channels may be stimulated by elevated cAMP levels.

Tremorgenic Indole Alkaloids Potently Inhibit Smooth Muscle High-Conductance Calcium-Activated Potassium Channels

Biochemistry ◽  
1994 ◽  
Vol 33 (19) ◽  
pp. 5819-5828 ◽  
Author(s):  
Hans-Guenther Knaus ◽  
Owen B. McManus ◽  
Seok H. Lee ◽  
William A. Schmalhofer ◽  
Margarita Garcia-Calvo ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Potassium Channels ◽  
Indole Alkaloids ◽  
Calcium Activated Potassium Channels ◽  
High Conductance

scholarly journals Distribution of high-conductance calcium-activated potassium channels in rat vestibular epithelia

2009 ◽  
Vol 517 (2) ◽  
pp. 134-145 ◽  
Author(s):  
Felix E. Schweizer ◽  
David Savin ◽  
Cindy Luu ◽  
David R. Sultemeier ◽  
Larry F. Hoffman
Keyword(s):  
Potassium Channels ◽  
Calcium Activated Potassium Channels ◽  
High Conductance

scholarly journals Expression and function of calcium-activated potassium channels in human glioma cells

Glia ◽  
2006 ◽  
Vol 54 (3) ◽  
pp. 223-233 ◽  
Author(s):  
Amy K. Weaver ◽  
Valerie C. Bomben ◽  
Harald Sontheimer
Keyword(s):  
Potassium Channels ◽  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Calcium Activated Potassium Channels ◽  
And Function

Pharmacology and structure of high conductance calcium-activated potassium channels

1994 ◽  
Vol 6 (8) ◽  
pp. 861-870 ◽  
Author(s):  
Hans-Günther Knaus ◽  
Andreas Eberhart ◽  
Hartmut Glossmann ◽  
Petraki Munujos ◽  
Gregory J. Kaczorowski ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Calcium Activated Potassium Channels ◽  
High Conductance

scholarly journals Functional role of the β subunit of high conductance calcium-activated potassium channels

Neuron ◽  
1995 ◽  
Vol 14 (3) ◽  
pp. 645-650 ◽  
Author(s):  
Owen B McManus ◽  
Lisa M.H Helms ◽  
Leo Pallanck ◽  
Barry Ganetzky ◽  
Richard Swanson ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Functional Role ◽  
Β Subunit ◽  
Calcium Activated Potassium Channels ◽  
High Conductance

Selective, Direct Activation of High-Conductance, Calcium-Activated Potassium Channels Causes Smooth Muscle Relaxation

2012 ◽  
Vol 81 (4) ◽  
pp. 567-577 ◽  
Author(s):  
Cristiano G. Ponte ◽  
Owen B. McManus ◽  
William A. Schmalhofer ◽  
Dong-Ming Shen ◽  
Ge Dai ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Potassium Channels ◽  
Muscle Relaxation ◽  
Smooth Muscle Relaxation ◽  
Direct Activation ◽  
Calcium Activated Potassium Channels ◽  
High Conductance
Sign in / Sign up

Export Citation Format

Share Document