Reactivity of Cysteine-49 and Its Influence on the Activation of Microsomal Glutathione Transferase 1:  Evidence for Subunit Interaction†

Biochemistry ◽  
2000 ◽  
Vol 39 (49) ◽  
pp. 15144-15149 ◽  
Author(s):  
Richard Svensson ◽  
Rosanna Rinaldi ◽  
Stellan Swedmark ◽  
Ralf Morgenstern
Keyword(s):  
Glutathione Transferase ◽  
Subunit Interaction ◽  
Microsomal Glutathione

Parameters for the Two-Dimensional Crystallization of the Membrane Protein Microsomal Glutathione Transferase

1998 ◽  
Vol 123 (2) ◽  
pp. 87-96 ◽  
Author(s):  
Ingeborg Schmidt-Krey ◽  
Gerd Lundqvist ◽  
Ralf Morgenstern ◽  
Hans Hebert
Keyword(s):  
Membrane Protein ◽  
Glutathione Transferase ◽  
Two Dimensional ◽  
Microsomal Glutathione

The distribution of microsomal glutathione transferase among different organelles, different organs, and different organisms

1984 ◽  
Vol 33 (22) ◽  
pp. 3609-3614 ◽  
Author(s):  
Ralf Morgenstern ◽  
Gerd Lundqvist ◽  
Göran Andersson ◽  
Lennart Balk ◽  
Joseph W. Depierre
Keyword(s):  
Glutathione Transferase ◽  
Microsomal Glutathione

scholarly journals Global Kinetic Mechanism of Microsomal Glutathione Transferase 1 and Insights into Dynamic Enzyme Activation

Biochemistry ◽  
2017 ◽  
Vol 56 (24) ◽  
pp. 3089-3098 ◽  
Author(s):  
Linda Spahiu ◽  
Johan Ålander ◽  
Astrid Ottosson-Wadlund ◽  
Richard Svensson ◽  
Carina Lehmer ◽  
...  
Keyword(s):  
Glutathione Transferase ◽  
Kinetic Mechanism ◽  
Enzyme Activation ◽  
Microsomal Glutathione

scholarly journals Leukotriene C synthase in mouse mastocytoma cells. An enzyme distinct from cytosolic and microsomal glutathione transferases

1988 ◽  
Vol 250 (3) ◽  
pp. 713-718 ◽  
Author(s):  
M Söderström ◽  
S Hammarström ◽  
B Mannervik
Keyword(s):  
Microsomal Fraction ◽  
Glutathione Transferase ◽  
Specific Activity ◽  
Glutathione Transferases ◽  
Leukotriene C4 ◽  
Cytosol Fraction ◽  
Mastocytoma Cells ◽  
Specific Activities ◽  
Leukotriene A4 ◽  
Microsomal Glutathione

Leukotriene C4 synthesis was studied in preparations from mouse mastocytoma cells. Enzymic conjugation of leukotriene A4 with glutathione was catalysed by both the cytosol and the microsomal fraction. The specific activity of the microsomal fraction (7.8 nmol/min per mg of protein) was 17 times that of the cytosol fraction. The cytosol fraction of the mastocytoma cells contained two glutathione transferases, which were purified to homogeneity and characterized. A microsomal glutathione transferase was purified from mouse liver; this enzyme was shown by immunoblot analysis to be present in the mastocytoma microsomal fraction at a concentration one-tenth or less of that in the liver microsomal fraction. Both the cytosolic and the microsomal glutathione transferases in the mastocytoma cells were identified with enzymes previously characterized, by determining specific activities with various substrates, sensitivities to inhibitors, reactions with antibodies, and physical properties. The purified microsomal glutathione transferase from liver was inactive with leukotriene A4 or its methyl ester as substrate. The cytosolic enzymes displayed activity with leukotriene A4, but their specific activities and intracellular concentrations were too low to account for the leukotriene C4 formation in the mastocytoma cells. The microsomal fraction of the cells contained an enzyme distinguishable by various criteria from the previously studied glutathione transferases. This membrane-bound enzyme, leukotriene C synthase (leukotriene A4:glutathione S-leukotrienyltransferase), appears to carry the main responsibility for the biosynthesis of leukotriene C4.

Microsomal glutathione transferase 1: mechanism and functional roles

2011 ◽  
Vol 43 (2) ◽  
pp. 300-306 ◽  
Author(s):  
Ralf Morgenstern ◽  
Jie Zhang ◽  
Katarina Johansson
Keyword(s):  
Glutathione Transferase ◽  
Functional Roles ◽  
Microsomal Glutathione

scholarly journals Human liver microsomal glutathione transferase

FEBS Letters ◽  
1993 ◽  
Vol 315 (1) ◽  
pp. 77-80 ◽  
Author(s):  
E. Mosialou ◽  
C. Andersson ◽  
G. Lundqvist ◽  
G. Andersson ◽  
T. Bergman ◽  
...  
Keyword(s):  
Human Liver ◽  
Glutathione Transferase ◽  
Microsomal Glutathione

Microsomal glutathione transferase 1 attenuated ROS-induced lipid peroxidation in Apostichopus japonicus

2017 ◽  
Vol 73 ◽  
pp. 79-87 ◽  
Author(s):  
Zhen Zhang ◽  
Zhimeng Lv ◽  
Yina Shao ◽  
Qiongfen Qiu ◽  
Weiwei Zhang ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Glutathione Transferase ◽  
Apostichopus Japonicus ◽  
Microsomal Glutathione
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