Interaction of the Antitumor Compound Cryptophycin-52 with Tubulin†

Biochemistry ◽  
2000 ◽  
Vol 39 (46) ◽  
pp. 14121-14127 ◽  
Author(s):  
Dulal Panda ◽  
Vidya Ananthnarayan ◽  
Gary Larson ◽  
Chuan Shih ◽  
Mary Ann Jordan ◽  
...  
Keyword(s):  
Antitumor Compound ◽  
Cryptophycin 52

Inhibition of macromolecular synthesis by cryptophycin-52

2002 ◽  
Vol 13 (10) ◽  
pp. 1061-1068 ◽  
Author(s):  
Balanehru Subramanian ◽  
Alexander Nakeff ◽  
Joseph E Media ◽  
Richard A Wiegand ◽  
Frederick A Valeriote
Keyword(s):  
Macromolecular Synthesis ◽  
Cryptophycin 52

scholarly journals Isolation Detection and Characterization of Syringolin A produced from the Probiotic Strain Bacillus Cereus Isolated from Donkey Milk

2018 ◽  
Vol 1 (2) ◽  
Author(s):  
Rashmi D ◽  
Sharmila T ◽  
Sushama Patil ◽  
Onkar Apine ◽  
Srinivas Sistla ◽  
...  
Keyword(s):  
Probiotic Strain ◽  
Uv Spectra ◽  
Organic Layer ◽  
Characteristic Peak ◽  
Antitumor Compound ◽  
Solvent Systems ◽  
Culture Supernatants ◽  
Layer Chromatography ◽  
Economical Process

Syringolin A is a non-ribosomal virulence factor secreted by few Pseudomonas strains. Syringolin A is an well known irreversible proteasome inhibitor and antitumor compound. The present study is focused on the extraction of Syringolin A through a non-tedious and economical process. Syringolin A is extracted from culture supernatants by the immiscible organic layer by mixing of dichloromethane or chloroform (trichloromethane). Syringolin A was identified by the characteristic peak at 350 nm by UV spectra. The compound was further characterized by Thin Layer Chromatography (TLC) with the retention value, Rf was found to be in the range of 0.78-0.83 run using a combination of solvent systems water and methanol.  The molecular weight of the compound was found to be 492.2614 g mol-1 identified and analyzed by UHPLC–QTOF-MS analysis. Due to its significant pharmacological importance in proliferative diseases, further studies on production and optimization of these compounds are necessary.   

scholarly journals Sulforaphane: Expected to Become a Novel Antitumor Compound

2020 ◽  
Vol 28 (4) ◽  
pp. 439-446 ◽  
Author(s):  
Geting Wu ◽  
Yuanliang Yan ◽  
Yangying Zhou ◽  
Yumei Duan ◽  
Shuangshuang Zeng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Antitumor Effect ◽  
Malignant Tumors ◽  
Inhibitory Effects ◽  
Traditional Chinese Herbal Medicine ◽  
Chinese Herbal ◽  
Alternative Systems ◽  
Antitumor Compound ◽  
Functional Mechanisms ◽  
Potential Biomarkers

Natural products are becoming increasingly popular in a variety of traditional, complementary, and alternative systems due to their potency and slight side effects. Natural compounds have been shown to be effective against many human diseases, especially cancers. Sulforaphane (SFE) is a traditional Chinese herbal medicine. In recent years, an increasing number of studies have been conducted to evaluate the antitumor effect of SFE. The roles of SFE in cancers are mainly through the regulation of potential biomarkers to activate or inhibit related signaling pathways. SFE has exhibited promising inhibitory effects on breast cancer, lung cancer, liver cancer, and other malignant tumors. In this review, we summarized the reports on the activity and functional mechanisms of SFE in cancer treatment and explored the efficacy and toxicity of SFE.

The microtubule-active antitumor compound TTI-237 has both paclitaxel-like and vincristine-like properties

2009 ◽  
Vol 64 (4) ◽  
pp. 681-689 ◽  
Author(s):  
Carl F. Beyer ◽  
Nan Zhang ◽  
Richard Hernandez ◽  
Danielle Vitale ◽  
Thai Nguyen ◽  
...  
Keyword(s):  
Antitumor Compound

scholarly journals Molecular basis of resistance to the microtubule-depolymerizing antitumor compound plocabulin

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Areti Pantazopoulou ◽  
Carlos María Galmarini ◽  
Miguel A. Peñalva
Keyword(s):  
Molecular Basis ◽  
Antitumor Compound

scholarly journals Isolation of an Antitumor Compound from Agaricus blazei Murill and Its Mechanism of Action

2001 ◽  
Vol 131 (5) ◽  
pp. 1409-1413 ◽  
Author(s):  
Takeshi Takaku ◽  
Yoshiyuki Kimura ◽  
Hiromichi Okuda
Keyword(s):  
Mechanism Of Action ◽  
Agaricus Blazei ◽  
Antitumor Compound ◽  
Agaricus Blazei Murill
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