In vivo activity on murine tumors of a novel antitumor compound, N-?-dimethylaminoethyl 9-carboxy-5-hydroxy-10-methoxybenzo[a]phenazine-6-carboxamide sodium salt (NC-190)

1989 ◽  
Vol 23 (3) ◽  
Author(s):  
Shiro Nakaike ◽  
Takehiro Yamagishi ◽  
Kazunori Samata ◽  
Keiko Nishida ◽  
Kouko Inazuki ◽  
...  
Keyword(s):  
Sodium Salt ◽  
Murine Tumors ◽  
Antitumor Compound

Treatment of Murine Tumors Using Dual-Frequency Ultrasound in an Experimental in Vivo Model

2009 ◽  
Vol 35 (5) ◽  
pp. 756-763 ◽  
Author(s):  
Amir H. Barati ◽  
Manijhe Mokhtari-Dizaji ◽  
Hossein Mozdarani ◽  
S. Zahra Bathaie ◽  
Zuhair M. Hassan
Keyword(s):  
In Vivo Model ◽  
Dual Frequency ◽  
Murine Tumors ◽  
Frequency Ultrasound

scholarly journals Antitumor and antimetastatic activity of interleukin 12 against murine tumors.

1993 ◽  
Vol 178 (4) ◽  
pp. 1223-1230 ◽  
Author(s):  
M J Brunda ◽  
L Luistro ◽  
R R Warrier ◽  
R B Wright ◽  
B R Hubbard ◽  
...  
Keyword(s):  
T Cells ◽  
Nk Cell ◽  
Critical Role ◽  
Cell Activity ◽  
Interleukin 12 ◽  
Reticulum Cell ◽  
Complete Disappearance ◽  
Antitumor Effects ◽  
Murine Tumors

It has recently been demonstrated that in vivo administration of murine interleukin 12 (IL-12) to mice results in augmentation of cytotoxic natural killer (NK)/lymphocyte-activated killer cell activity, enhancement of cytolytic T cell generation, and induction of interferon gamma secretion. In this study, the in vivo activity of murine IL-12 against a number of murine tumors has been evaluated. Experimental pulmonary metastases or subcutaneous growth of the B16F10 melanoma were markedly reduced in mice treated intraperitoneally with IL-12, resulting in an increase in survival time. The therapeutic effectiveness of IL-12 was dose dependent and treatment of subcutaneous tumors could be initiated up to 14 d after injection of tumor cells. Likewise, established experimental hepatic metastases and established subcutaneous M5076 reticulum cell sarcoma and Renca renal cell adenocarcinoma tumors were effectively treated by IL-12 at doses which resulted in no gross toxicity. Local peritumoral injection of IL-12 into established subcutaneous Renca tumors resulted in regression and complete disappearance of these tumors. IL-12 was as effective in NK cell-deficient beige mice or in mice depleted of NK cell activity by treatment with antiasialo GM1, suggesting that NK cells are not the primary cell type mediating the antitumor effects of this cytokine. However, the efficacy of IL-12 was greatly reduced in nude mice suggesting the involvement of T cells. Furthermore, depletion of CD8+ but not CD4+ T cells significantly reduced the efficacy of IL-12. These results demonstrate that IL-12 has potent in vivo antitumor and antimetastatic effects against murine tumors and demonstrate as well the critical role of CD8+ T cells in mediating the antitumor effects against subcutaneous tumors.

scholarly journals Solvolysis of the Tumor-Inhibiting Ru(III)-Complex trans-Tetrachlorobis(Indazole)Ruthenate(III)

2000 ◽  
Vol 7 (4) ◽  
pp. 225-232 ◽  
Author(s):  
Thomas Pieper ◽  
Wolfgang Peti ◽  
Bernhard K. Keppler
Keyword(s):  
Sodium Salt ◽  
Buffer System ◽  
Spectroscopic Techniques ◽  
Tumor Models ◽  
Solubility In Water ◽  
Aqueous Acetonitrile ◽  
Hydrolysis Of

The ruthenium(III) complex Hlnd trans-[RuCl4,(ind)2], with two trans-standing indazole (ind) ligands bound to ruthenium via nitrogen, shows remarkable activity in different tumor models in vitro and in vivo. The solvolysis of the complex trans-[RuCl4,(ind)2]- has been investigated by means of spectroscopic techniques (UV/vis, NMR)in different solvents. We investigated the indazolium as well as the sodium salt, the latter showing improved solubility in water. In aqueous acetonitrile and ethanol the solvolysis results in one main solvento complex. The hydrolysis of the complex is more complicated and depends on the pH of the solution as well as on the buffer system.

scholarly journals Direct in vivo transfer of plasmid DNA into murine tumors: effects of endotoxin presence and transgene localization.

2001 ◽  
Vol 48 (3) ◽  
pp. 795-800 ◽  
Author(s):  
M Budryk ◽  
T Cichoń ◽  
S Szala
Keyword(s):  
Plasmid Dna ◽  
Murine Tumors

The purpose of this study was to investigate the effect of endotoxin presence in plasmid DNA preparations on the efficiency of transfection achieved in vivo with B16(F10) and Renca tumors and to determine transgene localization. Our data show that endotoxin markedly decreases the efficiency of transfection. Furthermore, the transgene transferred in vivo can be found in both neoplastic and normal (most likely myofibroblast) cells lying in proximity of the administration site.

Percutaneous absorption of methotrexate as its sodium salt in vivo

1987 ◽  
Vol 6 (1) ◽  
pp. 9-12
Author(s):  
N. Bailey David ◽  
Joseph J. Coffee ◽  
R. Briggs John
Keyword(s):  
Sodium Salt ◽  
Percutaneous Absorption

Dendritic cells modified to express CD40 ligand elicit therapeutic immunity against preexisting murine tumors

Blood ◽  
2000 ◽  
Vol 96 (1) ◽  
pp. 91-99 ◽  
Author(s):  
Toshiaki Kikuchi ◽  
Malcolm A. S. Moore ◽  
Ronald G. Crystal
Keyword(s):  
Dendritic Cells ◽  
Cytotoxic T Lymphocyte ◽  
Tumor Regression ◽  
Ex Vivo ◽  
Tumor Model ◽  
Adenovirus Vector ◽  
Cd40 Ligand ◽  
Murine Tumors

CD40 ligand (CD40L) is essential for the initiation of antigen-specific T-cell responses. This study is based on the hypothesis that dendritic cells (DCs) genetically modified ex vivo to express CD40L will enhance in vivo presentation of tumor antigen to the cellular immune system with consequent induction of antitumor immunity to suppress tumor growth. To examine this concept, subcutaneous murine tumors were injected with bone marrow-derived DCs that had been modified in vitro with an adenovirus (Ad) vector expressing murine CD40L (AdmCD40L). In B16 (H-2b, melanoma) and CT26 (H-2d, colon cancer) murine models, intratumoral injection of 2 × 106 AdmCD40L-modified DCs (CD40L-DCs) to established (day 8) subcutaneous tumors resulted in sustained tumor regression and survival advantage. This antitumor effect was sustained when the number of CD40L-DCs were reduced 10-fold to 2 × 105. Analysis of spleens from CD40L-DC–treated animals demonstrated that CD40L-DCs injected into the subcutaneous CT26 flank tumors migrated to the spleen, resulting in activation of immune-relevant processes. Consistent with this concept, intratumoral administration of CD40L-DCs elicited tumor-specific cytotoxic T-lymphocyte responses, and the transfer of spleen cells from CD40L-DC–treated mice efficiently protected naive mice against a subsequent tumor challenge. In a distant 2-tumor model of metastatic disease, an untreated B16 tumor in the right flank regressed in parallel with a left B16 tumor treated with direct injection of CD40L-DCs. These results support the concept that genetic modification of DCs with a recombinant CD40L adenovirus vector may be a useful strategy for directly activating DCs for cancer immunotherapy.

In vitro and in vivo anticancer activity of mitozolomide and sparsomycin in human tumor xenografts, murine tumors and human bone marrow

1990 ◽  
Vol 116 (6) ◽  
pp. 550-556 ◽  
Author(s):  
Heinz H. Fiebig ◽  
Dietmar P. Berger ◽  
Karin Köpping ◽  
Harry C. J. Ottenheijm ◽  
Zbigniew Zylicz
Keyword(s):  
Bone Marrow ◽  
Anticancer Activity ◽  
Human Tumor ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Human Tumor Xenografts ◽  
Tumor Xenografts ◽  
Murine Tumors

The Prostaglandin E 1 Analog, Misoprostol, a Normal Tissue Protector, Does Not Protect Four Murine Tumors In Vivo from Radiation Injury

1995 ◽  
Vol 142 (3) ◽  
pp. 281 ◽  
Author(s):  
Wayne R. Hanson ◽  
Weining Zhen ◽  
Ling Geng ◽  
Nancy Hunter ◽  
Luka Milas
Keyword(s):  
Normal Tissue ◽  
Radiation Injury ◽  
Prostaglandin E ◽  
Murine Tumors
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