Control of Directionality in Nonribosomal Peptide Synthesis:  Role of the Condensation Domain in Preventing Misinitiation and Timing of Epimerization†

Biochemistry ◽  
2000 ◽  
Vol 39 (34) ◽  
pp. 10439-10447 ◽  
Author(s):  
Uwe Linne ◽  
Mohamed A. Marahiel
Keyword(s):  
Peptide Synthesis ◽  
Nonribosomal Peptide ◽  
Nonribosomal Peptide Synthesis ◽  
Condensation Domain

scholarly journals HAMA: a multiplexed LC-MS/MS assay for specificity profiling of adenylate-forming enzymes

2019 ◽  
Vol 10 (44) ◽  
pp. 10395-10399 ◽  
Author(s):  
Aleksa Stanišić ◽  
Annika Hüsken ◽  
Hajo Kries
Keyword(s):  
Peptide Synthesis ◽  
Nonribosomal Peptide ◽  
Nonribosomal Peptide Synthesis

Adenylation enzymes are engineering targets in ribosomal and nonribosomal peptide synthesis. Through multiplexed LC-MS/MS measurement of hydroxamates, the HAMA assay records specificity profiles of these enzymes in a snap.

Regulation of Nonribosomal Peptide Synthesis as a Mechanism of Antifungal Activity of Probiotics Based on the Bacteria Genera Bacillus and Paenibacillus

2021 ◽  
pp. 111-121
Author(s):  
Nikita Vasilchenko ◽  
Maksim Kulikov ◽  
Varvara Stacenko ◽  
Viktor Pakhomov ◽  
Natalia Kulikova ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Peptide Synthesis ◽  
Nonribosomal Peptide ◽  
Nonribosomal Peptide Synthesis
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