Determination of the Three-Dimensional Structure of the Bifunctional .alpha.-Amylase/Trypsin Inhibitor from Ragi Seeds by NMR Spectroscopy

Biochemistry ◽  
1995 ◽  
Vol 34 (26) ◽  
pp. 8281-8293 ◽  
Author(s):  
Stefan Strobl ◽  
Peter Muehlhahn ◽  
Reimond Bernstein ◽  
Ronald Wiltscheck ◽  
Klaus Maskos ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Trypsin Inhibitor ◽  
Three Dimensional ◽  
Alpha Amylase ◽  
Dimensional Structure ◽  
Three Dimensional Structure

scholarly journals Macrocyclic Tetramers – Structural Investigation of Peptide-Peptoid Hybrids

2021 ◽  
Author(s):  
Claudine Herlan ◽  
Anna Sonnefeld ◽  
Thomas Gloge ◽  
Julian Brückel ◽  
Luisa Schlee ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Bioactive Compounds ◽  
Rational Design ◽  
Structural Investigation ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
X Ray ◽  
Three Dimensional Structure ◽  
X Ray Scattering

The determination of the three-dimensional structure is a key step for the identification of new targets as well as the rational design of bioactive compounds. Herein, we report the synthesis and the structural elucidation of novel tetrameric macrocycles. Measurements were taken in solid and solution states with the help of X-ray scattering and NMR spectroscopy. The investigations made will help to find diverse applications for this new, promising compound class.

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