Low Molecular Weight Polyethylenimine Conjugated Gold Nanoparticles as Efficient Gene Vectors

2010 ◽  
Vol 21 (5) ◽  
pp. 836-843 ◽  
Author(s):  
Chu Hu ◽  
Qi Peng ◽  
Fujie Chen ◽  
Zhenlin Zhong ◽  
Renxi Zhuo
Keyword(s):  
Molecular Weight ◽  
Gold Nanoparticles ◽  
Low Molecular Weight ◽  
Efficient Gene ◽  
Gene Vectors

scholarly journals Water-soluble low-molecular-weight cellulose chains radially oriented on gold nanoparticles

Cellulose ◽  
2011 ◽  
Vol 18 (4) ◽  
pp. 929-936 ◽  
Author(s):  
Yukiko Enomoto-Rogers ◽  
Hiroshi Kamitakahara ◽  
Arata Yoshinaga ◽  
Toshiyuki Takano
Keyword(s):  
Molecular Weight ◽  
Gold Nanoparticles ◽  
Water Soluble ◽  
Low Molecular Weight

In situ formation of AuNPs using fatty N-acylamino hydrazide organogelators as templates

2019 ◽  
Vol 43 (1) ◽  
pp. 295-303 ◽  
Author(s):  
Renata Ongaratto ◽  
Naiane Conte ◽  
Caroline R. Montes D’Oca ◽  
Rafael C. Brinkerhoff ◽  
Caroline Pires Ruas ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Gold Nanoparticles ◽  
Low Molecular Weight ◽  
In Situ Formation ◽  
First Time

This work reports, for the first time, the synthesis of new fatty N-acylamino hydrazides and demonstrates the activity of these compounds as low-molecular-weight organic gelators and templates for preparation of gold nanoparticles (AuNPs).

The Effects of Polymer Coating of Gold Nanoparticles on Oxidative Stress and DNA Damage

2020 ◽  
Vol 39 (4) ◽  
pp. 328-340
Author(s):  
Gamze Tilbe Sen ◽  
Gizem Ozkemahli ◽  
Reza Shahbazi ◽  
Pınar Erkekoglu ◽  
Kezban Ulubayram ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Molecular Weight ◽  
Dna Damage ◽  
Gold Nanoparticles ◽  
Polyethylene Glycol ◽  
High Molecular Weight ◽  
Hepg2 Cells ◽  
The Body ◽  
Low Molecular Weight ◽  
Antioxidant Parameters

Gold nanoparticles (AuNPs) have been widely used in many biological and biomedical applications. In this regard, their surface modification is of paramount importance in order to increase their cellular uptake, delivery capability, and optimize their distribution inside the body. The aim of this study was to examine the effects of AuNPs on cytotoxicity, oxidant/antioxidant parameters, and DNA damage in HepG2 cells and investigate the potential toxic effects of different surface modifications such as polyethylene glycol (PEG) and polyethyleneimine (PEI; molecular weights of 2,000 (low molecular weight [LMW]) and 25,000 (high molecular weight [HMW]). The study groups were determined as AuNPs, PEG-coated AuNPs (AuNPs/PEG), low-molecular weight polyethyleneimine-coated gold nanoparticles (AuNPs/PEI LMW), and high-molecular weight polyethyleneimine-coated gold nanoparticles (AuNPs/PEI HMW). After incubating HepG2 cells with different concentrations of nanoparticles for 24 hours, half maximal inhibitory concentrations (the concentration that kills 50% of the cells) were determined as 166.77, 257.73, and 198.44 µg/mL for AuNPs, AuNPs/PEG, and AuNPs/PEI LMW groups, respectively. Later, inhibitory concentration 30 (IC30, the concentration that kills 30% of the cells) doses were calculated, and further experiments were performed on cells that were exposed to IC30 doses. Although intracellular reactive oxygen species levels significantly increased in all nanoparticles, AuNPs as well as AuNPs/PEG did not cause any changes in oxidant/antioxidant parameters. However, AuNPs/PEI HMW particularly induced oxidative stress as evidence of alterations in lipid peroxidation and protein oxidation. These results suggest that at IC30 doses, AuNPs do not affect oxidative stress and DNA damage significantly. Polyethylene glycol coating does not have an impact on toxicity, however PEI coating (particularly HMW) can induce oxidative stress.

A Biodegradable Low Molecular Weight Polyethylenimine Derivative as Low Toxicity and Efficient Gene Vector

2009 ◽  
Vol 20 (2) ◽  
pp. 322-332 ◽  
Author(s):  
Yuting Wen ◽  
Shirong Pan ◽  
Xin Luo ◽  
Xuan Zhang ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight ◽  
Gene Vector ◽  
Efficient Gene ◽  
Low Toxicity

Harvesting Low Molecular Weight Biomarkers Using Gold Nanoparticles

ACS Nano ◽  
2015 ◽  
Vol 9 (6) ◽  
pp. 5750-5759 ◽  
Author(s):  
Luai R. Khoury ◽  
Riki Goldbart ◽  
Tamar Traitel ◽  
Giora Enden ◽  
Joseph Kost
Keyword(s):  
Molecular Weight ◽  
Gold Nanoparticles ◽  
Low Molecular Weight

Starburst low-molecular weight polyethylenimine for efficient gene delivery

2011 ◽  
Vol 100A (1) ◽  
pp. 134-140 ◽  
Author(s):  
Yanjun Zhao ◽  
Rulei Yang ◽  
Dong Liu ◽  
Mingjing Sun ◽  
Lijun Zhou ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Gene Delivery ◽  
Low Molecular Weight ◽  
Efficient Gene
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