A New Method to Produce MonoPEGylated Dimeric Cytokines Shown with Human Interferon-α2b

2009 ◽  
Vol 20 (10) ◽  
pp. 1899-1907 ◽  
Author(s):  
Chien-Hsing Chang ◽  
Edmund A. Rossi ◽  
Thomas M. Cardillo ◽  
Diane L. Nordstrom ◽  
William J. McBride ◽  
...  
Keyword(s):  
New Method ◽  
Human Interferon ◽  
Interferon Α2b

The role of lac operon and lac repressor in the induction using lactose for the expression of periplasmic human interferon-α2b by Escherichia coli

2011 ◽  
Vol 62 (4) ◽  
pp. 1427-1435 ◽  
Author(s):  
Joo Shun Tan ◽  
Ramakrishnan Nagasundara Ramanan ◽  
Tau Chuan Ling ◽  
Shuhaimi Mustafa ◽  
Arbakariya B. Ariff
Keyword(s):  
Escherichia Coli ◽  
Lac Repressor ◽  
Human Interferon ◽  
Lac Operon ◽  
Interferon Α2b

Purification and conformational properties of a human interferon α2b produced in Escherichia coli

2001 ◽  
Vol 33 (3) ◽  
pp. 173 ◽  
Author(s):  
Alejandro Beldarraín ◽  
Yai Cruz ◽  
Oscar Cruz ◽  
Monica Navarro ◽  
Miriela Gil
Keyword(s):  
Escherichia Coli ◽  
Human Interferon ◽  
Conformational Properties ◽  
Interferon Α2b

Antiviral activity of extracts of transgenic chicory and lettuce plants with the human interferon α2b gene

2012 ◽  
Vol 46 (5) ◽  
pp. 285-290 ◽  
Author(s):  
N. A. Matvieieva ◽  
Yu. I. Kudryavets ◽  
A. A. Likhova ◽  
A. M. Shakhovskij ◽  
N. A. Bezdenezhnykh ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Human Interferon ◽  
Interferon Α2b

scholarly journals Functions of Traditional Chinese Medicine Combined with Recombinant Human Interferon α2b in Cervical Intraepithelial Neoplasias Patients

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Wei Ding ◽  
Xiaoyan Li ◽  
Baojun Ji ◽  
Zhenna Wang
Keyword(s):  
Cervical Cancer ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Cancer Patients ◽  
Inflammatory Factors ◽  
Human Interferon ◽  
Control Group ◽  
Study Group ◽  
Interferon Α2b ◽  
Negative Conversion

Cervical cancer is a common malignant neoplasm in women, and its incidence is increasing year by year. This study explored the effects of traditional Chinese medicine combined with recombinant human interferon α2b in cervical cancer patients. 178 cervical intraepithelial neoplasias (CIN) combined with high-risk HPV-positive patients from June 2017 to August 2020 were divided into the study group (n = 89 cases) and the control group (n = 89 cases) by the random number table method. Patients in the control group were treated with recombinant human interferon α2b, and the study group was treated with traditional Chinese medicine (TCM) on the basis of the control group. After treatment, the recurrence rate in the study group was significantly decreased while the human papillomavirus (HPV) negative conversion rate was significantly increased. 3 months after treatment, the TCM symptom scores in the study group were lower than in the control group. Moreover, serum levels of inflammatory factors decreased in both groups, and the decrease was more significant in the study group. After treatment, the ultrasound parameters were significantly decreased in the study group than in the control group. In conclusion, traditional Chinese medicine combined with recombinant human interferon α2b in cervical cancer patients could effectively improve the negative conversion rate of HPV infection, the level of inflammatory factors, reduce the degree of cervical erosion, and enhance the immunity of patients with high safety and significantly improve the quality of life.

scholarly journals Development and biological activity of long-acting recombinant human interferon-α2b

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Qian Zhang ◽  
Chao Wang ◽  
Fenlian Ma ◽  
Lihong Yao ◽  
Hanchun Gao ◽  
...  
Keyword(s):  
Biological Activity ◽  
Human Interferon ◽  
Long Acting ◽  
Interferon Α2b

scholarly journals Zinc mediated dimer of human interferon-α2b revealed by X-ray crystallography

Structure ◽  
1996 ◽  
Vol 4 (12) ◽  
pp. 1453-1463 ◽  
Author(s):  
Ramaswamy Radhakrishnan ◽  
Leigh J Walter ◽  
Alan Hruza ◽  
Paul Reichert ◽  
Paul P Trotta ◽  
...  
Keyword(s):  
Human Interferon ◽  
X Ray ◽  
X Ray Crystallography ◽  
Interferon Α2b
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