Polyaspartamide-Based Oligo-ethylenimine Brushes with High Buffer Capacity and Low Cytotoxicity for Highly Efficient Gene Delivery

2009 ◽  
Vol 20 (3) ◽  
pp. 440-446 ◽  
Author(s):  
Min Zhang ◽  
Min Liu ◽  
Ya-Nan Xue ◽  
Shi-Wen Huang ◽  
Ren-Xi Zhuo
Keyword(s):  
Gene Delivery ◽  
Buffer Capacity ◽  
Highly Efficient ◽  
Efficient Gene ◽  
Low Cytotoxicity ◽  
High Buffer Capacity

scholarly journals Cyclen-Based Cationic Lipids for Highly Efficient Gene Delivery towards Tumor Cells

PLoS ONE ◽  
2011 ◽  
Vol 6 (8) ◽  
pp. e23134 ◽  
Author(s):  
Qing-Dong Huang ◽  
Guo-Xing Zhong ◽  
Yang Zhang ◽  
Jiang Ren ◽  
Yun Fu ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Tumor Cells ◽  
Cationic Lipids ◽  
Highly Efficient ◽  
Efficient Gene

Design and synthesis of a fluorescent amino poly(glycidyl methacrylate) for efficient gene delivery

2019 ◽  
Vol 7 (11) ◽  
pp. 1875-1881 ◽  
Author(s):  
Hongtao Chen ◽  
Shusen You ◽  
Qing Cai ◽  
Yang Zheng ◽  
Liqun Zhang ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Atom Transfer Radical Polymerization ◽  
Radical Polymerization ◽  
Glycidyl Methacrylate ◽  
Dna Delivery ◽  
Atom Transfer ◽  
Design And Synthesis ◽  
Efficient Gene ◽  
Low Cytotoxicity ◽  
Delivery Efficiency

A fluorescent amino poly(glycidyl methacrylate) (PGOHMA) was synthesized by atom transfer radical polymerization (ATRP) and post-polymerization. PGOHMA has low cytotoxicity and high DNA delivery efficiency.

Functionalized Superparamagnetic Nanoparticles for Highly-Efficient Gene Delivery

2013 ◽  
Vol 13 (2) ◽  
pp. 746-750
Author(s):  
Xiaowen Wang ◽  
Benke Chen ◽  
Xin Yang ◽  
Jieying Zhang ◽  
Linyun Zhao ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Superparamagnetic Nanoparticles ◽  
Highly Efficient ◽  
Efficient Gene

scholarly journals Biocleavable Polycationic Micelles as Highly Efficient Gene Delivery Vectors

2010 ◽  
Vol 5 (11) ◽  
pp. 1804-1811 ◽  
Author(s):  
Min Zhang ◽  
Ya-Nan Xue ◽  
Min Liu ◽  
Ren-Xi Zhuo ◽  
Shi-Wen Huang
Keyword(s):  
Gene Delivery ◽  
Highly Efficient ◽  
Gene Delivery Vectors ◽  
Efficient Gene

scholarly journals Local Gene Delivery System by Bubble Liposomes and Ultrasound Exposure into Joint Synovium

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Yoichi Negishi ◽  
Yuka Tsunoda ◽  
Yoko Endo-Takahashi ◽  
Yusuke Oda ◽  
Ryo Suzuki ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Transfer ◽  
Gene Delivery ◽  
Delivery System ◽  
Imaging System ◽  
Effective Means ◽  
Gene Delivery System ◽  
Highly Efficient ◽  
Efficient Gene

Recently, we have developed novel polyethylene glycol modified liposomes (bubble liposomes; BL) entrapping an ultrasound (US) imaging gas, which can work as a gene delivery tool with US exposure. In this study, we investigated the usefulness of US-mediated gene transfer systems with BL into synoviocytes in vitro and joint synovium in vivo. Highly efficient gene transfer could be achieved in the cultured primary synoviocytes transfected with the combination of BL and US exposure, compared to treatment with plasmid DNA (pDNA) alone, pDNA plus BL, or pDNA plus US. When BL was injected into the knee joints of mice, and US exposure was applied transcutaneously to the injection site, highly efficient gene expression could be observed in the knee joint transfected with the combination of BL and US exposure, compared to treatment with pDNA alone, pDNA plus BL, or pDNA plus US. The localized and prolonged gene expression was also shown by an in vivo luciferase imaging system. Thus, this local gene delivery system into joint synovium using the combination of BL and US exposure may be an effective means for gene therapy in joint disorders.

scholarly journals Aerosolized nanogram quantities of plasmid DNA mediate highly efficient gene delivery to mouse airway epithelium

2005 ◽  
Vol 12 (3) ◽  
pp. 493-501 ◽  
Author(s):  
Carsten Rudolph ◽  
Ulrike Schillinger ◽  
Aurora Ortiz ◽  
Christian Plank ◽  
Monika M. Golas ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Plasmid Dna ◽  
Airway Epithelium ◽  
Highly Efficient ◽  
Efficient Gene

Highly Efficient Gene Delivery for Bladder Cancers by Intravesically Administered Replication-Competent Retroviral Vectors

2007 ◽  
Vol 13 (15) ◽  
pp. 4511-4518 ◽  
Author(s):  
Eiji Kikuchi ◽  
Silvia Menendez ◽  
Choichiro Ozu ◽  
Makoto Ohori ◽  
Carlos Cordon-Cardo ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Retroviral Vectors ◽  
Highly Efficient ◽  
Efficient Gene
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