Water-Soluble Contrast Agents Targeted at the Estrogen Receptor for Molecular Magnetic Resonance Imaging

2007 ◽  
Vol 18 (5) ◽  
pp. 1361-1365 ◽  
Author(s):  
Chidambaram Gunanathan ◽  
Adi Pais ◽  
Edna Furman-Haran ◽  
Dalia Seger ◽  
Erez Eyal ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Estrogen Receptor ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Water Soluble ◽  
Resonance Imaging ◽  
Water Soluble Contrast ◽  
Water Soluble Contrast Agents

Facile one-pot synthesis of different surfactant-functionalized water-soluble Fe3O4 nanoparticles as magnetic resonance imaging contrast agents for melanoma tumors

RSC Advances ◽  
2015 ◽  
Vol 5 (62) ◽  
pp. 50557-50564 ◽  
Author(s):  
Longyun Wu ◽  
ChunYan Yang ◽  
Zhongwen Lv ◽  
FengWen Cui ◽  
Lijun Zhao ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Mr Imaging ◽  
Contrast Agents ◽  
Sodium Citrate ◽  
Water Soluble ◽  
Resonance Imaging ◽  
One Pot ◽  
Magnetic Resonance Imaging Contrast

A facile and efficient one-pot solvothermal strategy is described to synthesize Fe3O4 nanoparticles (NPs) modified with sodium citrate, polyvinylpyrrolidone and l-asparagine for in vivo magnetic resonance (MR) imaging of melanoma cells.

Water-soluble d-glucuronic acid coated ultrasmall mixed Ln/Mn (Ln = Gd and Dy) oxide nanoparticles and their application to magnetic resonance imaging

2014 ◽  
Vol 2 (9) ◽  
pp. 1287-1295 ◽  
Author(s):  
Badrul Alam Bony ◽  
Jong Su Baeck ◽  
Yongmin Chang ◽  
Ji Eun Bae ◽  
Kwon Seok Chae ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Glucuronic Acid ◽  
Mri Contrast Agents ◽  
Water Soluble ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Mn Oxide

Mixed (A) Gd/Mn and (B) Dy/Mn oxide nanoparticles are confirmed to be potential T1 and/or T2 MRI contrast agents, respectively.

scholarly journals Assessment of the Relaxation-Enhancing Properties of a Nitroxide-Based Contrast Agent TEEPO-Glc with In Vivo Magnetic Resonance Imaging

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Maiju Soikkeli ◽  
Mikko I. Kettunen ◽  
Riikka Nivajärvi ◽  
Venla Olsson ◽  
Seppo Rönkkö ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Tumor Targeting ◽  
Water Soluble ◽  
Organic Radicals ◽  
Resonance Imaging ◽  
Metal Free ◽  
Stable Nitroxide

Magnetic resonance imaging examinations are frequently carried out using contrast agents to improve the image quality. Practically all clinically used contrast agents are based on paramagnetic metals and lack in selectivity and specificity. A group of stable organic radicals, nitroxides, has raised interest as new metal-free contrast agents for MRI. Their structures can easily be modified to incorporate different functionalities. In the present study, a stable nitroxide TEEPO (2,2,6,6-tetraethylpiperidin-1-oxyl) was linked to a glucose moiety (Glc) to construct a water-soluble, potentially tumor-targeting compound with contrast-enhancing ability. The ability was assessed with in vivo MRI experiments. The constructed TEEPO-Glc agent proved to shorten the T1 relaxation time in tumor, while the T1 time in healthy brain tissue remained the same. The results indicate the potential of TEEPO-Glc as a valuable addition to the growing field of metal-free contrast enhancement in MRI-based diagnostics.

Sign in / Sign up

Export Citation Format

Share Document