Facile one-pot synthesis of different surfactant-functionalized water-soluble Fe3O4 nanoparticles as magnetic resonance imaging contrast agents for melanoma tumors

RSC Advances ◽  
2015 ◽  
Vol 5 (62) ◽  
pp. 50557-50564 ◽  
Author(s):  
Longyun Wu ◽  
ChunYan Yang ◽  
Zhongwen Lv ◽  
FengWen Cui ◽  
Lijun Zhao ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Mr Imaging ◽  
Contrast Agents ◽  
Sodium Citrate ◽  
Water Soluble ◽  
Resonance Imaging ◽  
One Pot ◽  
Magnetic Resonance Imaging Contrast

A facile and efficient one-pot solvothermal strategy is described to synthesize Fe3O4 nanoparticles (NPs) modified with sodium citrate, polyvinylpyrrolidone and l-asparagine for in vivo magnetic resonance (MR) imaging of melanoma cells.

Supramolecular and Biomacromolecular Enhancement of Metal-Free Magnetic Resonance Imaging Contrast Agents

2019 ◽  
Author(s):  
Hamilton Lee ◽  
Jenica Lumata ◽  
Michael A. Luzuriaga ◽  
Candace Benjamin ◽  
Olivia Brohlin ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Single Molecule ◽  
Organic Radical ◽  
Resonance Imaging ◽  
Metal Free ◽  
Physiological Conditions ◽  
Magnetic Resonance Imaging Contrast

<div><div><div><p>Many contrast agents for magnetic resonance imaging are based on gadolinium, however side effects limit their use in some patients. Organic radical contrast agents (ORCAs) are potential alternatives, but are reduced rapidly in physiological conditions and have low relaxivities as single molecule contrast agents. Herein, we use a supramolecular strategy where cucurbit[8]uril binds with nanomolar affinities to ORCAs and protects them against biological reductants to create a stable radical in vivo. We further over came the weak contrast by conjugating this complex on the surface of a self-assembled biomacromolecule derived from the tobacco mosaic virus.</p></div></div></div>

Supramolecular and Biomacromolecular Enhancement of Metal-Free Magnetic Resonance Imaging Contrast Agents

2019 ◽  
Author(s):  
Hamilton Lee ◽  
Jenica Lumata ◽  
Michael A. Luzuriaga ◽  
Candace Benjamin ◽  
Olivia Brohlin ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Single Molecule ◽  
Organic Radical ◽  
Resonance Imaging ◽  
Metal Free ◽  
Physiological Conditions ◽  
Magnetic Resonance Imaging Contrast

<div><div><div><p>Many contrast agents for magnetic resonance imaging are based on gadolinium, however side effects limit their use in some patients. Organic radical contrast agents (ORCAs) are potential alternatives, but are reduced rapidly in physiological conditions and have low relaxivities as single molecule contrast agents. Herein, we use a supramolecular strategy where cucurbit[8]uril binds with nanomolar affinities to ORCAs and protects them against biological reductants to create a stable radical in vivo. We further over came the weak contrast by conjugating this complex on the surface of a self-assembled biomacromolecule derived from the tobacco mosaic virus.</p></div></div></div>

scholarly journals Supramolecular and biomacromolecular enhancement of metal-free magnetic resonance imaging contrast agents

2020 ◽  
Vol 11 (8) ◽  
pp. 2045-2050 ◽  
Author(s):  
Hamilton Lee ◽  
Arezoo Shahrivarkevishahi ◽  
Jenica L. Lumata ◽  
Michael A. Luzuriaga ◽  
Laurel M. Hagge ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Organic Radical ◽  
Resonance Imaging ◽  
Nitroxide Radicals ◽  
Metal Free ◽  
Magnetic Resonance Imaging Contrast ◽  
Poor Stability

Supramolecular/macromolecular organic radical contrast agents (smORCAs) overcome many of the limitations of nitroxide radicals for use in magnetic resonance imaging in vivo like poor stability and weak contrast.

scholarly journals Harnessing methylotrophs as a bacterial platform to reduce adverse effects of the use of the heavy lanthanide gadolinium in magnetic resonance imaging

2021 ◽  
Author(s):  
Nathan Michael Good ◽  
Harvey Lee ◽  
Emily R Hawker ◽  
Assaf Gilad ◽  
Norma Cecilia Martinez-Gomez
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Methylotrophic Bacteria ◽  
Resonance Imaging ◽  
Vascular Abnormalities ◽  
Heavy Lanthanides ◽  
Magnetic Resonance Imaging Contrast ◽  
Detection And Diagnosis

Gadolinium is a key component of magnetic resonance imaging contrast agents that are critical tools for enhanced detection and diagnosis of tissue and vascular abnormalities. Untargeted post-injection deposition of gadolinium in vivo, and association with diseases like nephrogenic systemic fibrosis, has alerted regulatory agencies to re-evaluate their widespread use and generated calls for safer gadolinium-based contrast agents (GBCAs). Increasing anthropogenic gadolinium in surface water has also raised concerns of potential bioaccumulation in plants and animals. Methylotrophic bacteria can acquire, transport, store and use light lanthanides as part of a cofactor complex with pyrroloquinoline quinone (PQQ), an essential component of XoxF-type methanol dehydrogenases (MDHs), a critical enzyme for methylotrophic growth with methanol. We report robust gadolinium-dependent methanol growth of a genetic variant of Methylorubrum extorquens AM1, named evo-HLn, for evolved for heavy lanthanides. Genetic adaptation of evo-HLn resulted in increased xox1 promoter and XoxF MDH activities, transport and storage of Gd3+, and augmented biosynthesis of PQQ. Gadolinium-grown cells exhibited a shorter T1 relaxation time compared to cells with lanthanum or no lanthanide when analyzed by MRI. In addition, evo-HLn was able to grow on methanol using the GBCA Gd-DTPA as the sole gadolinium source, showing the potential of this strain for the development of novel GBCAs and gadolinium recovery from medical waste and/or wastewater.

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