Activatable Cell Penetrating Peptide-Conjugated Nanoparticles with Enhanced Permeability for Site-Specific Targeting Delivery of Anticancer Drug

2013 ◽  
Vol 24 (3) ◽  
pp. 419-430 ◽  
Author(s):  
Huimin Xia ◽  
Guangzhi Gu ◽  
Quanyin Hu ◽  
Zhongyang Liu ◽  
Mengyin Jiang ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Cell Penetrating Peptide ◽  
Site Specific ◽  
Specific Targeting ◽  
Cell Penetrating ◽  
Targeting Delivery

Dual-modified liposomes with a two-photon-sensitive cell penetrating peptide and NGR ligand for siRNA targeting delivery

Biomaterials ◽  
2015 ◽  
Vol 48 ◽  
pp. 84-96 ◽  
Author(s):  
Yang Yang ◽  
YanFang Yang ◽  
XiangYang Xie ◽  
ZhiYuan Wang ◽  
Wei Gong ◽  
...  
Keyword(s):  
Cell Penetrating Peptide ◽  
Sensitive Cell ◽  
Two Photon ◽  
Cell Penetrating ◽  
Targeting Delivery

Angiopep-2 and Activatable Cell-Penetrating Peptide Dual-Functionalized Nanoparticles for Systemic Glioma-Targeting Delivery

2014 ◽  
Vol 11 (8) ◽  
pp. 2755-2763 ◽  
Author(s):  
Huile Gao ◽  
Shuang Zhang ◽  
Shijie Cao ◽  
Zhi Yang ◽  
Zhiqing Pang ◽  
...  
Keyword(s):  
Cell Penetrating Peptide ◽  
Functionalized Nanoparticles ◽  
Cell Penetrating ◽  
Targeting Delivery

scholarly journals Control of protein palmitoylation by regulating substrate recruitment to a zDHHC-protein acyltransferase

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Fiona Plain ◽  
Jacqueline Howie ◽  
Jennifer Kennedy ◽  
Elaine Brown ◽  
Michael J. Shattock ◽  
...  
Keyword(s):  
Cell Penetrating Peptide ◽  
Amphipathic Helix ◽  
Post Translational Modification ◽  
Site Specific ◽  
Cellular Processes ◽  
Na Pump ◽  
Protein Palmitoylation ◽  
Therapeutic Gain ◽  
Cell Penetrating ◽  
A Cell

AbstractAlthough palmitoylation regulates numerous cellular processes, as yet efforts to manipulate this post-translational modification for therapeutic gain have proved unsuccessful. The Na-pump accessory sub-unit phospholemman (PLM) is palmitoylated by zDHHC5. Here, we show that PLM palmitoylation is facilitated by recruitment of the Na-pump α sub-unit to a specific site on zDHHC5 that contains a juxtamembrane amphipathic helix. Site-specific palmitoylation and GlcNAcylation of this helix increased binding between the Na-pump and zDHHC5, promoting PLM palmitoylation. In contrast, disruption of the zDHHC5-Na-pump interaction with a cell penetrating peptide reduced PLM palmitoylation. Our results suggest that by manipulating the recruitment of specific substrates to particular zDHHC-palmitoyl acyl transferases, the palmitoylation status of individual proteins can be selectively altered, thus opening the door to the development of molecular modulators of protein palmitoylation for the treatment of disease.

Au nanoshell-coated superparamagnetic Fe3O4–silica composite nanoparticles with surface-modification of an activatable cell-penetrating peptide for tumor-targeted multimode bioimaging and photothermal therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (88) ◽  
pp. 85587-85594
Author(s):  
Yunfang Jiang ◽  
Qianyu Zhang ◽  
Xinghua Liu ◽  
Yifu Chen ◽  
Li Wang ◽  
...  
Keyword(s):  
Surface Modification ◽  
Photothermal Therapy ◽  
Composite Nanoparticles ◽  
Cell Penetrating Peptide ◽  
Tumor Site ◽  
Site Specific ◽  
Silica Composite ◽  
Cell Penetrating ◽  
Surface Modified

The superparamagnetic Fe3O4–silica composite nanoparticles coated with Au nanoshells were prepared and subsequently surface-modified with PEG conjugated ACPP for realizing the tumor site-specific multimode bioimaging and photothermal therapy.

scholarly journals Cell penetrating thiazole peptides inhibit c-MYC expression via site-specific targeting of c-MYC G-quadruplex

2018 ◽  
Vol 46 (11) ◽  
pp. 5355-5365 ◽  
Author(s):  
Debasish Dutta ◽  
Manish Debnath ◽  
Diana Müller ◽  
Rakesh Paul ◽  
Tania Das ◽  
...  
Keyword(s):  
Site Specific ◽  
Specific Targeting ◽  
G Quadruplex ◽  
Cell Penetrating

Identification of BP16 as a non-toxic cell-penetrating peptide with highly efficient drug delivery properties

2014 ◽  
Vol 12 (10) ◽  
pp. 1652-1663 ◽  
Author(s):  
Marta Soler ◽  
Marta González-Bártulos ◽  
David Soriano-Castell ◽  
Xavi Ribas ◽  
Miquel Costas ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Cellular Uptake ◽  
Therapeutic Agents ◽  
Cell Penetrating Peptide ◽  
Highly Efficient ◽  
Cell Penetrating ◽  
Efficient Vector

BP16is a non-toxic cell-penetrating peptide with high cellular uptakein vitro. This peptide is an efficient vector for the delivery of therapeutic agents into cells, as has been shown for the anticancer drug chlorambucil.

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