Cellular Internalization Kinetics of (Luciferin-)Cell-Penetrating Peptide Conjugates

2010 ◽  
Vol 21 (9) ◽  
pp. 1662-1672 ◽  
Author(s):  
Emelía Eiríksdóttir ◽  
Imre Mäger ◽  
Taavi Lehto ◽  
Samir El Andaloussi ◽  
Ülo Langel
Keyword(s):  
Cell Penetrating Peptide ◽  
Cellular Internalization ◽  
Peptide Conjugates ◽  
Cell Penetrating ◽  
Internalization Kinetics ◽  
Kinetics Of

scholarly journals Stimuli-Sensitive Cell Penetrating Peptide-Modified Nanocarriers

Processes ◽  
2019 ◽  
Vol 7 (10) ◽  
pp. 727 ◽  
Author(s):  
Perche
Keyword(s):  
Therapeutic Index ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating Peptide ◽  
Cellular Internalization ◽  
Normal Tissues ◽  
Formidable Challenge ◽  
Cell Penetrating ◽  
Stimuli Sensitive ◽  
Responsive Cell

The integration of drugs into nanocarriers favorably altered their pharmacodynamics and pharmacokinetics compared to free drugs, and increased their therapeutic index. However, selective cellular internalization in diseased tissues rather than normal tissues still presents a formidable challenge. In this chapter I will cover solutions involving environment-responsive cell-penetrating peptides (CPPs). I will discuss properties of CPPs as universal cellular uptake enhancers, and the modifications imparted to CPP-modified nanocarriers to confine CPP activation to diseased tissues.

Cell-penetrating-peptide-based delivery of oligonucleotides: an overview

2007 ◽  
Vol 35 (4) ◽  
pp. 775-779 ◽  
Author(s):  
R. Abes ◽  
A.A. Arzumanov ◽  
H.M. Moulton ◽  
S. Abes ◽  
G.D. Ivanova ◽  
...  
Keyword(s):  
Cell Penetrating Peptides ◽  
Peptide Delivery ◽  
Cell Penetrating Peptide ◽  
Cellular Internalization ◽  
Structure Activity ◽  
Cell Penetrating ◽  
Transactivator Of Transcription ◽  
Endocytic Vesicles ◽  
Oligonucleotide Analogues ◽  
Phosphorodiamidate Morpholino Oligomers

Cationic CPPs (cell-penetrating peptides) have been used largely for intracellular delivery of low-molecular-mass drugs, biomolecules and particles. Most cationic CPPs bind to cell-associated glycosaminoglycans and are internalized by endocytosis, although the detailed mechanisms involved remain controversial. Sequestration and degradation in endocytic vesicles severely limits the efficiency of cytoplasmic and/or nuclear delivery of CPP-conjugated material. Re-routing the splicing machinery by using steric-block ON (oligonucleotide) analogues, such as PNAs (peptide nucleic acids) or PMOs (phosphorodiamidate morpholino oligomers), has consequently been inefficient when ONs are conjugated with standard CPPs such as Tat (transactivator of transcription), R9 (nona-arginine), K8 (octalysine) or penetratin in the absence of endosomolytic agents. New arginine-rich CPPs such as (R-Ahx-R)4 (6-aminohexanoic acid-spaced oligo-arginine) or R6 (hexa-arginine)–penetratin conjugated to PMO or PNA resulted in efficient splicing correction at non-cytotoxic doses in the absence of chloroquine. SAR (structure–activity relationship) analyses are underway to optimize these peptide delivery vectors and to understand their mechanisms of cellular internalization.

Lipid–Cell-Penetrating-Peptide Conjugates as Effective Delivery Systems

Synlett ◽  
2017 ◽  
Vol 28 (15) ◽  
pp. 1897-1900
Author(s):  
Zi-Gang Li ◽  
Yan-Hong Jiang ◽  
Hui Zhao ◽  
Yuan Tian
Keyword(s):  
Cellular Uptake ◽  
Biological Research ◽  
Cell Penetrating Peptide ◽  
Peptide Conjugates ◽  
Cellular Toxicity ◽  
Wide Range ◽  
Cell Penetrating ◽  
Effective Delivery ◽  
Cellular Permeability ◽  
Small Molecule Therapeutics

A lipid–cell-penetrating-peptide (CPP) conjugate was designed to deliver cargoes with poor cellular permeability, including peptides or small-molecule therapeutics, into cells. The lipid–CPP conjugate facilitated the cellular uptake of cargoes noncovalently through an ATP-dependent micropinocytosis mechanism. This delivery system is simple, efficient, has minimal cellular toxicity, and might be useful in a wide range of biological research.

scholarly journals Cell-penetrating peptide conjugates to enhance the antitumor effect of paclitaxel on drug-resistant lung cancer

Drug Delivery ◽  
2017 ◽  
Vol 24 (1) ◽  
pp. 752-764 ◽  
Author(s):  
Ziqing Duan ◽  
Cuitian Chen ◽  
Jing Qin ◽  
Qi Liu ◽  
Qi Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Antitumor Effect ◽  
Cell Penetrating Peptide ◽  
Drug Resistant ◽  
Peptide Conjugates ◽  
Cell Penetrating

scholarly journals Cell penetrating peptide conjugates of steric block oligonucleotides

2008 ◽  
Vol 60 (4-5) ◽  
pp. 517-529 ◽  
Author(s):  
Bernard Lebleu ◽  
Hong M. Moulton ◽  
Rachida Abes ◽  
Gabriela D. Ivanova ◽  
Said Abes ◽  
...  
Keyword(s):  
Cell Penetrating Peptide ◽  
Peptide Conjugates ◽  
Cell Penetrating

scholarly journals Delivering aminopyridine ligands into cancer cells through conjugation to the cell-penetrating peptide BP16

2016 ◽  
Vol 14 (17) ◽  
pp. 4061-4070 ◽  
Author(s):  
M. Soler ◽  
M. González-Bártulos ◽  
E. Figueras ◽  
A. Massaguer ◽  
L. Feliu ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cell Penetrating Peptide ◽  
Peptide Conjugates ◽  
Cell Penetrating ◽  
High Cytotoxicity

Peptide conjugates incorporating a red-ox active aminopyridine ligand bound to the cell-penetrating peptide BP16 display high cytotoxicity.

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