scholarly journals Immobilization of Iron Oxide Magnetic Nanoparticles for Enhancement of Vessel Wall Magnetic Resonance Imaging—AnEx VivoFeasibility Study

2010 ◽  
Vol 21 (8) ◽  
pp. 1408-1412 ◽  
Author(s):  
Binh Thai Nguyen ◽  
Praveen Kumar Vemula ◽  
Dimitrios Mitsouras ◽  
Peng Yu ◽  
Ming Tao ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Magnetic Resonance ◽  
Vessel Wall ◽  
Resonance Imaging ◽  
Iron Oxide Magnetic Nanoparticles

Magnetic Resonance Imaging of Tumors with the Use of Iron Oxide Magnetic Nanoparticles as a Contrast Agent

2017 ◽  
Vol 162 (6) ◽  
pp. 808-811 ◽  
Author(s):  
A. S. Semkina ◽  
M. A. Abakumov ◽  
N. F. Grinenko ◽  
A. A. Lipengolts ◽  
N. V. Nukolova ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Resonance Imaging ◽  
Iron Oxide Magnetic Nanoparticles

Pheomelanin-coated iron oxide magnetic nanoparticles: a promising candidate for negative T2 contrast enhancement in magnetic resonance imaging

2015 ◽  
Vol 51 (56) ◽  
pp. 11194-11197 ◽  
Author(s):  
Alexandre D. A. Zottis ◽  
Jeovandro M. Beltrame ◽  
Luciano R. S. Lara ◽  
Thiago G. Costa ◽  
Mateus J. Feldhaus ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Magnetic Resonance ◽  
Water Soluble ◽  
Resonance Imaging ◽  
Promising Candidate ◽  
Magnetite Nanoparticle ◽  
Iron Oxide Magnetic Nanoparticles ◽  
Environmentally Friendly Approach

We describe herein a novel type of monodisperse water-soluble magnetite nanoparticle coated with pheomelanin using an environmentally-friendly approach in aqueous medium.

Magnetic iron oxide nanoparticles asT1contrast agents for magnetic resonance imaging

2018 ◽  
Vol 6 (6) ◽  
pp. 1280-1290 ◽  
Author(s):  
Y. Bao ◽  
J. A. Sherwood ◽  
Z. Sun
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Synthesis Parameters

This review discusses several aspects regarding ultrasmall magnetic nanoparticles asT1contrast agents, including synthesis, parameters affectingT1, and applications.

scholarly journals Intracellular labeling and quantification process by magnetic resonance imaging using iron oxide magnetic nanoparticles in rat C6 glioma cell line

2012 ◽  
Vol 10 (2) ◽  
pp. 216-221 ◽  
Author(s):  
Javier Bustamante Mamani ◽  
Lorena Favaro Pavon ◽  
Liza Aya Mabuchi Miyaki ◽  
Tatiana Tais Sibov ◽  
Fabiana Rossan ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Nanoparticles ◽  
Magnetic Resonance ◽  
Glioma Cells ◽  
C6 Glioma ◽  
C6 Glioma Cells ◽  
Resonance Imaging ◽  
Iron Oxide Magnetic Nanoparticles ◽  
Transfection Agent ◽  
Rat C6 Glioma

OBJECTIVE: To assess intracellular labeling and quantification by magnetic resonance imaging using iron oxide magnetic nanoparticles coated with biocompatible materials in rat C6 glioma cells in vitro. These methods will provide direction for future trials of tumor induction in vivo as well as possible magnetic hyperthermia applications. METHODS: Aminosilane, dextran, polyvinyl alcohol, and starch-coated magnetic nanoparticles were used in the qualitative assessment of C6 cell labeling via light microscopy. The influence of the transfection agent poly-L-lysine on cellular uptake was examined. The quantification process was performed by relaxometry analysis in T1 and T2weighted phantom images. RESULTS: Light microscopy revealed that the aminosilane-coated magnetic nanoparticles alone or complexed with poly-L-lysine showed higher cellular uptake than did the uncoated magnetic particles. The relaxivities of the aminosilane-coated magnetic nanoparticles with a hydrodynamic diameter of 50nm to a 3-T field were r1=(6.1±0.3)×10-5 ms-1mL/µg, r2=(5.3±0.1)× 10-4 ms-1mL/µg, with a ratio of r2 / r1 ≅ 9. The iron uptake in the cells was calculated by analyzing the relaxation rates (R1 and R2) using a mathematical relationship. CONCLUSIONS: C6 glioma cells have a high uptake efficiency for aminosilane-coated magnetic nanoparticles complexed with the transfection agent poly-L-lysine. The large ratio r2 / r1 ≅ 9 indicates that these magnetic nanoparticles are ideal for quantification by magnetic resonance imaging with T2-weighted imaging techniques.

scholarly journals Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
David Kovář ◽  
Aneta Malá ◽  
Jitka Mlčochová ◽  
Michal Kalina ◽  
Zdenka Fohlerová ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Magnetic Resonance ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Injection Rate ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Average Size

Magnetic nanoparticles produced using aqueous coprecipitation usually exhibit wide particle size distribution. Synthesis of small and uniform magnetic nanoparticles has been the subject of extensive research over recent years. Sufficiently small superparamagnetic iron oxide nanoparticles easily permeate tissues and may enhance the contrast in magnetic resonance imaging. Furthermore, their unique small size also allows them to migrate into cells and other body compartments. To better control their synthesis, a chemical coprecipitation protocol was carefully optimised regarding the influence of the injection rate of base and incubation times. The citrate-stabilised particles were produced with a narrow average size range below 2 nm and excellent stability. The stability of nanoparticles was monitored by long-term measurement of zeta potentials and relaxivity. Biocompatibility was tested on the Caki-2 cells with good tolerance. The application of nanoparticles for magnetic resonance imaging (MRI) was then evaluated. The relaxivities (r1,r2) and r2/r1 ratio calculated from MR images of prepared phantoms indicate the nanoparticles as a promising T2-contrast probe.

Magnetic resonance imaging quantification and biodistribution of magnetic nanoparticles using T1-enhanced contrast

2018 ◽  
Vol 6 (10) ◽  
pp. 1470-1478 ◽  
Author(s):  
Y. B. Lv ◽  
P. Chandrasekharan ◽  
Y. Li ◽  
X. L. Liu ◽  
J. P. Avila ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Relaxation Times ◽  
Oxide Nanoparticles ◽  
Resonance Imaging

Monodispersed 4 nm Gd-doped iron oxide nanoparticles (GdIONPs) were fabricated, and were as T1-weighted contrast agents to confirm the feasibility of non-invasively quantify and monitor IONPs in vivo based on MRI longitudinal relaxation times.

scholarly journals Magnetism for Drug Delivery, MRI and Hyperthermia Applications: a Review

2020 ◽  
Vol 11 (2) ◽  
pp. 8654-8668
Keyword(s):  
Magnetic Resonance Imaging ◽  
Drug Delivery ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Magnetic Resonance ◽  
Mri Contrast Agents ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Magnetic Resonance Imaging Mri

Superparamagnetic nanoparticles contain unique magnetic properties that differ from the bulk materials and are able to function at a cellular level due to their size, shape, and surface characteristics. These features make them attractive candidates for drug delivery systems, thermal mediators in hyperthermia, and magnetic resonance imaging (MRI) contrast agents. This review provides an up-to-date overview of the application of iron oxide nanoparticles in cancer diagnosis, drug delivery, treatment, and safety concerns related to these materials are considered, as well. Furthermore, the general principles and challenges of the magnetic behavior of nanoparticles in the field of oncology are also discussed. Firstly, the basic requirements for magnetic nanoparticles for biomedical applications are outlined. The close link between structure, shape, size, and magnetic characterization are described, which is considered essential for non-invasive imaging modality, innovative magnetic-driven nanocarriers, and treatment based on the overheating. In conclusion, investigation of the toxicity profile of novel nanoparticles is provided, as well. In the current review, the attention is focused on the role of magnetic nanoparticles, especially iron oxide nanoparticles in some bioapplications such as magnetic resonance imaging (MRI) contrast agents, targeted drug delivery, and magnetic hyperthermia systems.

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