How Drug Photodegradation Studies Led to the Promise of New Therapies and Some Fundamental Carbanion Reaction Dynamics along the Way

2009 ◽  
Vol 42 (5) ◽  
pp. 599-607 ◽  
Author(s):  
Gonzalo Cosa ◽  
Matthew Lukeman ◽  
J. C. Scaiano
Keyword(s):  
Reaction Dynamics ◽  
New Therapies ◽  
The Way

scholarly journals Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy

2016 ◽  
Vol 473 (10) ◽  
pp. 1329-1341 ◽  
Author(s):  
Itay Cohen ◽  
Olumide Kayode ◽  
Alexandra Hockla ◽  
Banumathi Sankaran ◽  
Derek C. Radisky ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Protein Engineering ◽  
Morbidity And Mortality ◽  
New Therapies ◽  
Combinatorial Protein Engineering ◽  
Pancreatic Cancers ◽  
The Way

Cancer is a leading cause of morbidity and mortality worldwide. The results presented in the present study pave the way to develop new therapies targeting mesotrypsin, an enzyme that contributes to progression and metastasis of lung, prostate, breast and pancreatic cancers.

scholarly journals Muscular dystrophy: the route to a cure: Genetic and cell therapies

2008 ◽  
Vol 30 (3) ◽  
pp. 18-21
Author(s):  
Taeyoung Koo ◽  
Takis Athanasopoulos ◽  
George Dickson
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Muscle Wasting ◽  
Therapeutic Approaches ◽  
Childhood Diseases ◽  
Cell Therapies ◽  
New Therapies ◽  
Clinical Evaluations ◽  
Dystrophin Protein ◽  
The Way

Duchenne muscular dystrophy (DMD) is one of the most common Xlinked and lifethreatening childhood diseases and affects about 1 in 3000 newborn boys. Lack of dystrophin protein causes severe progressive muscle wasting and death in the second/third decade of life, due to breathing and circulatory complications. Currently, there are no effective medications for DMD, but many differ ent therapeutic approaches are under active development. In the case of genetic and cell therapies, preclinical and clinical evaluations of safety and validity are paving the way towards effective new therapies which could be available routinely for DMD patients in the next 5 years.

Congenital vascular lesions, could MAPK and PI3K inhibitors pave the way to new therapies?

2021 ◽  
Vol 33 (2) ◽  
pp. 95-100
Author(s):  
Annouk Bisdorff-Bresson ◽  
Mélanie Eyries ◽  
Olivia Boccara
Keyword(s):  
Vascular Lesions ◽  
Pi3k Inhibitors ◽  
New Therapies ◽  
The Way

scholarly journals Recent advances in understanding and managing acne

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 792
Author(s):  
Ichiro Kurokawa ◽  
Keisuke Nakase
Keyword(s):  
Wound Healing ◽  
Sebaceous Gland ◽  
New Therapies ◽  
The Past ◽  
Recent Advances ◽  
Acne Treatment ◽  
The Way

Multidisciplinary investigations into the pathogenesis of acne have significantly progressed over the past three years. Studies of the etiology of acne from the perspectives, for example, of sebaceous gland biology, sebum, genetics, keratinization, differentiation, hair cycles, immunology, bacteriology, and wound healing have elucidated its pathogenesis. This has led to the development of new therapies and paved the way for advanced studies that will enable the further evolution of acne treatment.

Self-sacrifice for in-group's history: A diachronic perspective

2018 ◽  
Vol 41 ◽  
Author(s):  
Maria Babińska ◽  
Michal Bilewicz
Keyword(s):  
Clinical Psychology ◽  
Historical Events ◽  
Emotional Events ◽  
Reciprocal Process ◽  
The Way

AbstractThe problem of extended fusion and identification can be approached from a diachronic perspective. Based on our own research, as well as findings from the fields of social, political, and clinical psychology, we argue that the way contemporary emotional events shape local fusion is similar to the way in which historical experiences shape extended fusion. We propose a reciprocal process in which historical events shape contemporary identities, whereas contemporary identities shape interpretations of past traumas.

What is the purpose of cognition?

2020 ◽  
Vol 43 ◽  
Author(s):  
Aba Szollosi ◽  
Ben R. Newell
Keyword(s):  
Infinite Number ◽  
Human Cognition ◽  
The Way

Abstract The purpose of human cognition depends on the problem people try to solve. Defining the purpose is difficult, because people seem capable of representing problems in an infinite number of ways. The way in which the function of cognition develops needs to be central to our theories.

Peculiarity Parameters

1976 ◽  
Vol 32 ◽  
pp. 233-254
Author(s):  
H. M. Maitzen
Keyword(s):  
Magnetic Field ◽  
Magnetic Fields ◽  
Theoretical Work ◽  
Observational Evidence ◽  
Rotator Model ◽  
Peculiar Behaviour ◽  
Field Spectrum ◽  
Oblique Rotator ◽  
Ap Stars ◽  
The Way

Ap stars are peculiar in many aspects. During this century astronomers have been trying to collect data about these and have found a confusing variety of peculiar behaviour even from star to star that Struve stated in 1942 that at least we know that these phenomena are not supernatural. A real push to start deeper theoretical work on Ap stars was given by an additional observational evidence, namely the discovery of magnetic fields on these stars by Babcock (1947). This originated the concept that magnetic fields are the cause for spectroscopic and photometric peculiarities. Great leaps for the astronomical mankind were the Oblique Rotator model by Stibbs (1950) and Deutsch (1954), which by the way provided mathematical tools for the later handling pulsar geometries, anti the discovery of phase coincidence of the extrema of magnetic field, spectrum and photometric variations (e.g. Jarzebowski, 1960).

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