Enzyme-Responsive Hydrogel Microparticles for Pulmonary Drug Delivery

2014 ◽  
Vol 6 (13) ◽  
pp. 10313-10321 ◽  
Author(s):  
Emilie Secret ◽  
Stefan J. Kelly ◽  
Kelsey E. Crannell ◽  
Jennifer S. Andrew
Keyword(s):  
Drug Delivery ◽  
Pulmonary Drug Delivery ◽  
Hydrogel Microparticles

Matrix metalloproteinase-sensitive hydrogel microparticles for pulmonary drug delivery of small molecule drugs or proteins

2015 ◽  
Vol 3 (27) ◽  
pp. 5629-5634 ◽  
Author(s):  
Emilie Secret ◽  
Kelsey E. Crannell ◽  
Stefan J. Kelly ◽  
Maria Villancio-Wolter ◽  
Jennifer S. Andrew
Keyword(s):  
Drug Delivery ◽  
Matrix Metalloproteinases ◽  
Matrix Metalloproteinase ◽  
Small Molecule ◽  
Pulmonary Drug Delivery ◽  
Hydrogel Microparticles ◽  
Small Molecule Drugs

Hydrogel microparticles sensitive to matrix metalloproteinases are studied for release of drugs and proteins into the lungs.

Application of Chitosan and its Derivatives in Nanocarrier Based Pulmonary Drug Delivery Systems

2018 ◽  
Vol 5 (4) ◽  
Author(s):  
Kamal Dua ◽  
Mary Bebawy ◽  
Rajendra Awasthi ◽  
Rakesh K. Tekade ◽  
Muktika Tekade ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Pulmonary Drug Delivery

scholarly journals Polyhydroxyalkanoate Nanoparticles for Pulmonary Drug Delivery: Interaction with Lung Surfactant

Nanomaterials ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1482
Author(s):  
Olga Cañadas ◽  
Andrea García-García ◽  
M. Auxiliadora Prieto ◽  
Jesús Pérez-Gil
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Bacterial Species ◽  
High Surface ◽  
Lung Surfactant ◽  
Delivery Systems ◽  
Pulmonary Drug Delivery ◽  
Epifluorescence Microscopy ◽  
Energy Storage Materials ◽  
The Stability

Polyhydroxyalkanoates (PHA) are polyesters produced intracellularly by many bacterial species as energy storage materials, which are used in biomedical applications, including drug delivery systems, due to their biocompatibility and biodegradability. In this study, we evaluated the potential application of this nanomaterial as a basis of inhaled drug delivery systems. To that end, we assessed the possible interaction between PHA nanoparticles (NPs) and pulmonary surfactant using dynamic light scattering, Langmuir balances, and epifluorescence microscopy. Our results demonstrate that NPs deposited onto preformed monolayers of DPPC or DPPC/POPG bind these surfactant lipids. This interaction facilitated the translocation of the nanomaterial towards the aqueous subphase, with the subsequent loss of lipid from the interface. NPs that remained at the interface associated with liquid expanded (LE)/tilted condensed (TC) phase boundaries, decreasing the size of condensed domains and promoting the intermixing of TC and LE phases at submicroscopic scale. This provided the stability necessary for attaining high surface pressures upon compression, countering the destabilization induced by lipid loss. These effects were observed only for high NP loads, suggesting a limit for the use of these NPs in pulmonary drug delivery.

Pulmonary drug delivery with aerogels: engineering of alginate and alginate–hyaluronic acid microspheres

2021 ◽  
Vol 26 (5) ◽  
pp. 509-521
Author(s):  
Tamara Athamneh ◽  
Adil Amin ◽  
Edit Benke ◽  
Rita Ambrus ◽  
Pavel Gurikov ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Pulmonary Drug Delivery

Superparamagnetic electrospun microrods for magnetically-guided pulmonary drug delivery with magnetic heating

2021 ◽  
Vol 126 ◽  
pp. 112117
Author(s):  
Maria Nikolaou ◽  
Kyriakos Avraam ◽  
Argiris Kolokithas-Ntoukas ◽  
Aristides Bakandritsos ◽  
Frantisek Lizal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pulmonary Drug Delivery ◽  
Magnetic Heating

Alginate and hybrid alginate-hyaluronic acid aerogel microspheres as potential carrier for pulmonary drug delivery

2019 ◽  
Vol 150 ◽  
pp. 49-55 ◽  
Author(s):  
Tamara Athamneh ◽  
Adil Amin ◽  
Edit Benke ◽  
Rita Ambrus ◽  
Claudia S. Leopold ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Pulmonary Drug Delivery

Inhaled formulations and pulmonary drug delivery systems for respiratory infections

2015 ◽  
Vol 85 ◽  
pp. 83-99 ◽  
Author(s):  
Qi (Tony) Zhou ◽  
Sharon Shui Yee Leung ◽  
Patricia Tang ◽  
Thaigarajan Parumasivam ◽  
Zhi Hui Loh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Respiratory Infections ◽  
Delivery Systems ◽  
Pulmonary Drug Delivery
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