Gold Nanorod Enhanced Two-Photon Excitation Fluorescence of Photosensitizers for Two-Photon Imaging and Photodynamic Therapy

2014 ◽  
Vol 6 (4) ◽  
pp. 2700-2708 ◽  
Author(s):  
Tingting Zhao ◽  
Kuai Yu ◽  
Lin Li ◽  
Taishi Zhang ◽  
Zhenping Guan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Gold Nanorod ◽  
Two Photon ◽  
Photon Excitation ◽  
Photon Imaging ◽  
Two Photon Imaging ◽  
Two Photon Excitation

Gold nanorod-enhanced two-photon excitation fluorescence of conjugated oligomers for two-photon imaging guided photodynamic therapy

2019 ◽  
Vol 7 (46) ◽  
pp. 14693-14700 ◽  
Author(s):  
Tingting Zhao ◽  
Lin Li ◽  
Shuang Li ◽  
Xiao-Fang Jiang ◽  
Cuifeng Jiang ◽  
...  
Keyword(s):  
Optical Properties ◽  
Photodynamic Therapy ◽  
Gold Nanorod ◽  
Conjugated Oligomers ◽  
Two Photon ◽  
Photon Excitation ◽  
Photon Imaging ◽  
Two Photon Imaging ◽  
Two Photon Fluorescence ◽  
Photon Fluorescence

Plasmon enhanced two-photon fluorescence nanomaterials were developed to manipulate their optical properties for two-photon imaging guided photodynamic therapy.

scholarly journals Two-Color, Two-Photon Imaging at Long Excitation Wavelengths Using a Diamond Raman Laser

2016 ◽  
Vol 22 (4) ◽  
pp. 803-807 ◽  
Author(s):  
Johanna Trägårdh ◽  
Michelle Murtagh ◽  
Gillian Robb ◽  
Maddy Parsons ◽  
Jipeng Lin ◽  
...  
Keyword(s):  
Fluorescent Protein ◽  
Laser System ◽  
Raman Laser ◽  
Alexa Fluor ◽  
Ti:Sapphire Laser ◽  
Two Photon ◽  
Photon Excitation ◽  
Photon Imaging ◽  
Two Photon Imaging ◽  
Two Photon Excitation

AbstractWe demonstrate that the second-Stokes output from a diamond Raman laser, pumped by a femtosecond Ti:Sapphire laser, can be used to efficiently excite red-emitting dyes by two-photon excitation at 1,080 nm and beyond. We image HeLa cells expressing red fluorescent protein, as well as dyes such as Texas Red and Mitotracker Red. We demonstrate the potential for simultaneous two-color, two-photon imaging with this laser by using the residual pump beam for excitation of a green-emitting dye. We demonstrate this for the combination of Alexa Fluor 488 and Alexa Fluor 568. Because the Raman laser extends the wavelength range of the Ti:Sapphire laser, resulting in a laser system tunable to 680–1,200 nm, it can be used for two-photon excitation of a large variety and combination of dyes.

Biocompatible well-defined chromophore–polymer conjugates for photodynamic therapy and two-photon imaging

2013 ◽  
Vol 4 (1) ◽  
pp. 61-67 ◽  
Author(s):  
Cristina Cepraga ◽  
Thibault Gallavardin ◽  
Sophie Marotte ◽  
Pierre-Henri Lanoë ◽  
Jean-Christophe Mulatier ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Two Photon ◽  
Polymer Conjugates ◽  
Photon Imaging ◽  
Two Photon Imaging

scholarly journals Two-Photon–NIR-II Antimicrobial Graphene-Nanoagent for Ultraviolet–NIR Imaging and Photoinactivation

2021 ◽  
Author(s):  
WEN-SHUO KUO ◽  
Chia-Yuan Chang ◽  
Ping-Ching Wu ◽  
Jiu-Yao Wang
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Chemical Modification ◽  
Near Infrared ◽  
Photon Absorption ◽  
Excitation Wavelength ◽  
Strong Electron ◽  
Two Photon ◽  
Photon Excitation ◽  
Two Photon Excitation

Abstract BackgroundNitrogen doping and amino-group functionalization, which result in strong electron donation, can be achieved through chemical modification. Large π-conjugated systems of graphene quantum dot (GQD)-based materials acting as electron donors can be chemically manipulated with low two-photon excitation energy in a short photoexcitation time for improving the charge transfer efficiency of sorted nitrogen-doped amino acid–functionalized GQDs (sorted amino-N-GQDs). ResultsIn this study, a self-developed femtosecond Ti-sapphire laser optical system (222.7 nJ pixel−1 with 100-170 scans, approximately 0.65-1.11 s of total effective exposure times; excitation wavelength: 960 nm in the near-infrared II region) was used for chemical modification. The sorted amino-N-GQDs exhibited enhanced two-photon absorption, post-two-photon excitation stability, two-photon excitation cross-section, and two-photon luminescence through the radiative pathway. The lifetime and quantum yield of the sorted amino-N-GQDs decreased and increased, respectively. Furthermore, the sorted amino-N-GQDs exhibited excitation-wavelength-independent photoluminescence in the near-infrared region and generated reactive oxygen species after two-photon excitation. An increase in the size of the sorted amino-N-GQDs boosted photochemical and electrochemical efficacy and resulted in high photoluminescence quantum yield and highly efficient two-photon photodynamic therapy. ConclusionThe sorted dots can be used in two-photon contrast probes for tracking and localizing analytes during two-photon imaging in a biological environment and for conducting two-photon photodynamic therapy for eliminating infectious microbes.

Two-photon excitation nanoparticles for photodynamic therapy

2016 ◽  
Vol 45 (24) ◽  
pp. 6725-6741 ◽  
Author(s):  
Yizhong Shen ◽  
Adam J. Shuhendler ◽  
Deju Ye ◽  
Jing-Juan Xu ◽  
Hong-Yuan Chen
Keyword(s):  
Photodynamic Therapy ◽  
Two Photon ◽  
Photon Excitation ◽  
Two Photon Excitation

Integration of the two-photon excitation (TPE) technique and nanomaterials to construct TPE nanoparticle-based photosensitizers for PDT is summarized and reviewed.

Control of Photobleaching in Photodynamic Therapy Using the Photodecarbonylation Reaction of Ruthenium Phthalocyanine Complexes via Stepwise Two-Photon Excitation

2008 ◽  
Vol 112 (10) ◽  
pp. 3138-3143 ◽  
Author(s):  
Kazuyuki Ishii ◽  
Masahiko Shiine ◽  
Yoshitaka Shimizu ◽  
Shun-ichi Hoshino ◽  
Hisaku Abe ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Two Photon ◽  
Photon Excitation ◽  
Two Photon Excitation

Lysosome-targetable polythiophene nanoparticles for two-photon excitation photodynamic therapy and deep tissue imaging

2017 ◽  
Vol 5 (20) ◽  
pp. 3651-3657 ◽  
Author(s):  
Shaojing Zhao ◽  
Guangle Niu ◽  
Feng Wu ◽  
Li Yan ◽  
Hongyan Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Fluorescence Imaging ◽  
Cross Section ◽  
Tissue Imaging ◽  
Deep Tissue ◽  
Two Photon ◽  
Photon Excitation ◽  
Deep Tissue Imaging ◽  
Two Photon Excitation

Polythiophene nanoparticles with large TPA cross section and high1O2generation quantum yield have been developed for simultaneous lysosome-targetable fluorescence imaging and photodynamic therapy.

Engineered g-C3N4 Quantum Dots for Tunable Two-Photon Imaging and Photodynamic Therapy

2019 ◽  
Vol 2 (5) ◽  
pp. 1998-2005 ◽  
Author(s):  
Xiaoxia Wu ◽  
Lingyan Yang ◽  
Liang Luo ◽  
Guohua Shi ◽  
Xunbin Wei ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Photodynamic Therapy ◽  
Two Photon ◽  
Photon Imaging ◽  
Two Photon Imaging
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