Electrospun Biomimetic Fibrous Scaffold from Shape Memory Polymer of PDLLA-co-TMC for Bone Tissue Engineering

2014 ◽  
Vol 6 (4) ◽  
pp. 2611-2621 ◽  
Author(s):  
Min Bao ◽  
Xiangxin Lou ◽  
Qihui Zhou ◽  
Wen Dong ◽  
Huihua Yuan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Shape Memory ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Shape Memory Polymer ◽  
Fibrous Scaffold

scholarly journals Hierarchical starch-based fibrous scaffold for bone tissue engineering applications

2009 ◽  
Vol 3 (1) ◽  
pp. 37-42 ◽  
Author(s):  
Albino Martins ◽  
Sangwon Chung ◽  
Adriano J. Pedro ◽  
Rui A. Sousa ◽  
Alexandra P. Marques ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Engineering Applications ◽  
Fibrous Scaffold

Electrospun gelatin/poly(ε-caprolactone) fibrous scaffold modified with calcium phosphate for bone tissue engineering

2014 ◽  
Vol 44 ◽  
pp. 183-190 ◽  
Author(s):  
Izabella Rajzer ◽  
Elżbieta Menaszek ◽  
Ryszard Kwiatkowski ◽  
Josep A. Planell ◽  
Oscar Castano
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Fibrous Scaffold ◽  
Electrospun Gelatin

Collagen-Inspired Nano-fibrous Poly(L-lactic acid) Scaffolds for Bone Tissue Engineering Created from Reverse Solid Freeform Fabrication

2004 ◽  
Vol 823 ◽  
Author(s):  
Victor J. Chen ◽  
Laura A. Smith ◽  
Peter X. Ma
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Computer Aided Design ◽  
Type I Collagen ◽  
Polymer Concentration ◽  
Three Dimensional ◽  
Type I ◽  
Fibrous Scaffold

AbstractReverse solid freeform (SFF) fabrication was used to create highly-controlled macroporous structures in nano-fibrous poly (L-lactic acid) (PLLA) scaffolds. By using a computer-aided design (CAD) program to create a negative template for the scaffold, the three-dimensional (3-D) mold was created on a 3-D printer using a wax. After the template was printed, a solution of PLLA in tetrahydrofuran (THF) was cast into the mold, and was subsequently phase separated at -70°C which gives the nano-fibrous morphology. This resulted in a 3-D nano-fibrous scaffold with a uniform fiber mesh throughout the entire matrix, and greatly increased the surface area within the scaffold. Fiber diameters in these scaffolds were 50-500 nm, similar to type I collagen, and the densities of the fiber meshes can be altered by changing the polymer concentration. To examine the scaffold's potential for tissue regeneration, MC3T3-E1 osteoblasts were seeded and cultured on the scaffolds. Results show that the osteoblasts attached and proliferated on the scaffolds. After 6 weeks in culture, bone-like tissue was evident within the nano-fibrous scaffolds. By having the ability to control the macroporous architecture, interconnectivity, orientation, and external shape of the scaffold, as well as the nanometer-scaled fibrous features in the pore walls, this SFF fabrication/phase separation technique has great potential to design and create ideal scaffolds for bone tissue engineering.

scholarly journals MiRNA- Nanofiber, the Next Generation of Bioactive Scaffolds for Bone Regeneration: A Review

Micromachines ◽  
2021 ◽  
Vol 12 (12) ◽  
pp. 1472
Author(s):  
Davood Kharaghani ◽  
Eben Bashir Kurniwan ◽  
Muhammad Qamar Khan ◽  
Yuji Yoshiko
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Bone Development ◽  
Bioactive Molecules ◽  
Fibrous Scaffold ◽  
Bioactive Scaffolds ◽  
Alternative Treatment Option ◽  
The Impact

Scaffold-based bone tissue engineering has been introduced as an alternative treatment option for bone grafting due to limitations in the allograft. Not only physical conditions but also biological conditions such as gene expression significantly impact bone regeneration. Scaffolds in composition with bioactive molecules such as miRNA mimics provide a platform to enhance migration, proliferation, and differentiation of osteoprogenitor cells for bone regeneration. Among scaffolds, fibrous structures showed significant advantages in promoting osteogenic differentiation and bone regeneration via delivering bioactive molecules over the past decade. Here, we reviewed the bone and bone fracture healing considerations for the impact of miRNAs on bone regeneration. We also examined the methods used to improve miRNA mimics uptake by cells, the fabrication of fibrous scaffolds, and the effective delivery of miRNA mimics using fibrous scaffold and their processes for bone development. Finally, we offer our view on the principal challenges of miRNA mimics delivery by nanofibers for bone tissue engineering.

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