Strong Electroactive Biodegradable Shape Memory Polymer Networks Based on Star-Shaped Polylactide and Aniline Trimer for Bone Tissue Engineering

2015 ◽  
Vol 7 (12) ◽  
pp. 6772-6781 ◽  
Author(s):  
Meihua Xie ◽  
Ling Wang ◽  
Juan Ge ◽  
Baolin Guo ◽  
Peter X. Ma
Keyword(s):  
Tissue Engineering ◽  
Shape Memory ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Shape Memory Polymer ◽  
Polymer Networks

Electrospun Biomimetic Fibrous Scaffold from Shape Memory Polymer of PDLLA-co-TMC for Bone Tissue Engineering

2014 ◽  
Vol 6 (4) ◽  
pp. 2611-2621 ◽  
Author(s):  
Min Bao ◽  
Xiangxin Lou ◽  
Qihui Zhou ◽  
Wen Dong ◽  
Huihua Yuan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Shape Memory ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Shape Memory Polymer ◽  
Fibrous Scaffold

Porous shape memory scaffold of dextran and hydroxyapatite for minimum invasive implantation for bone tissue engineering applications

2020 ◽  
pp. 088532822095006
Author(s):  
Kai Huang ◽  
Mo-song Yang ◽  
Yu-jun Tang ◽  
Shi-Yong Ling ◽  
Feng Pan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Minimally Invasive ◽  
Shape Memory ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Porous Scaffold ◽  
Great Promise ◽  
Scanning Calorimetry ◽  
Engineering Applications

Minimally invasive implantation of a porous scaffold of large volume into bone defect site remains a challenge. Scaffolds based on shape memory polymer (SMP) show potential to be delivered in the compact form via minimally invasive surgery. The present study chooses poly (ε-caprolactone)-diols (PCL-diols) as the SMP to cross-link carboxyl dextran via ester bonds together with particle leaching method to yield a porous SMP scaffold. The inner surfaces of porous SMP scaffold are then mineralized via in situ precipitation to yield mineralized porous SMP-hydroxyapatite (SMP-HA) scaffold. The porous SMP-HA scaffold possesses pore size of 400–500 μm, with HA particles uniformly distributed and orientationally aligned on the inner surfaces of scaffold. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) are carried out to identify the HA deposition. The phase transition temperature of the scaffold is adjusted to 38°C via changing the dosage of PCL (molecule weight: 2800) to endow the scaffold with shape deformation and fixed properties, as well as well-performed shape recovery property under body temperature. Bone marrow mesenchymal stem cells (BMSCs) adhere on the inner surfaces of SMP-HA scaffold, exhibiting larger spreading area when compared to cells adhered on SMP scaffold without HA, promoting its osteogenesis. In vivo degradation showed that the scaffold degrades completely after 6 months post-implantation. At the same time, significant tissue and capillary invasion indicated that the present porous SMP-HA scaffold hold great promise towards bone tissue engineering applications.

Elastic poly( ε -caprolactone)-polydimethylsiloxane copolymer fibers with shape memory effect for bone tissue engineering

2016 ◽  
Vol 11 (1) ◽  
pp. 015007 ◽  
Author(s):  
Dan Kai ◽  
Molamma P Prabhakaran ◽  
Benjamin Qi Yu Chan ◽  
Sing Shy Liow ◽  
Seeram Ramakrishna ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Shape Memory ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Shape Memory Effect ◽  
Memory Effect
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