Synthesis and Enzymology of 2′-Deoxy-7-deazaisoguanosine Triphosphate and Its Complement: A Second Generation Pair in an Artificially Expanded Genetic Information System

2016 ◽  
Vol 5 (7) ◽  
pp. 672-678 ◽  
Author(s):  
Nilesh B. Karalkar ◽  
Nicole A. Leal ◽  
Myong-Sang Kim ◽  
Kevin M. Bradley ◽  
Steven A. Benner
Keyword(s):  
Information System ◽  
Genetic Information ◽  
Second Generation

scholarly journals Construction of a Drug Safety Assurance Information System Based on Clinical Genotyping

2012 ◽  
Vol 2012 ◽  
pp. 1-9
Author(s):  
John A. Springer ◽  
Nicholas V. Iannotti ◽  
Jon E. Sprague ◽  
Michael D. Kane
Keyword(s):  
Information System ◽  
Drug Safety ◽  
Genetic Information ◽  
Software Tool ◽  
Patient Specific ◽  
Domain Experts ◽  
Safety Assurance ◽  
Positive Assessment ◽  
Clinical Environments ◽  
Repeated Use

To capitalize on the vast potential of patient genetic information to aid in assuring drug safety, a substantial effort is needed in both the training of healthcare professionals and the operational enablement of clinical environments. Our research aims to satisfy these needs through the development of a drug safety assurance information system (GeneScription) based on clinical genotyping that utilizes patient-specific genetic information to predict and prevent adverse drug responses. In this paper, we present the motivations for this work, the algorithms at the heart of GeneScription, and a discussion of our system and its uses. We also describe our efforts to validate GeneScription through its evaluation by practicing pharmacists and pharmacy professors and its repeated use in training pharmacists. The positive assessment of the GeneScription software tool by these domain experts provides strong validation of the importance, accuracy, and effectiveness of GeneScription.

Analogues of P and Z as Efficient Artificially Expanded Genetic Information System

2018 ◽  
Vol 122 (34) ◽  
pp. 8134-8145 ◽  
Author(s):  
N. R. Jena ◽  
P. Das ◽  
B. Behera ◽  
P. C. Mishra
Keyword(s):  
Information System ◽  
Genetic Information

scholarly journals Artificially expanded genetic information system: a new base pair with an alternative hydrogen bonding pattern

2006 ◽  
Vol 34 (21) ◽  
pp. 6095-6101 ◽  
Author(s):  
Zunyi Yang ◽  
Daniel Hutter ◽  
Pinpin Sheng ◽  
A. Michael Sismour ◽  
Steven A. Benner
Keyword(s):  
Information System ◽  
Hydrogen Bonding ◽  
Base Pair ◽  
Genetic Information ◽  
Hydrogen Bonding Pattern ◽  
System A

scholarly journals Structural Basis of the Mispairing of an Artificially Expanded Genetic Information System

Chem ◽  
2016 ◽  
Vol 1 (6) ◽  
pp. 946-958 ◽  
Author(s):  
Linus F. Reichenbach ◽  
Ahmad Ahmad Sobri ◽  
Nathan R. Zaccai ◽  
Christopher Agnew ◽  
Nicholas Burton ◽  
...  
Keyword(s):  
Information System ◽  
Genetic Information ◽  
Structural Basis
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