An Aspergillus nidulans Platform for the Complete Cluster Refactoring and Total Biosynthesis of Fungal Natural Products

2020 ◽  
Author(s):  
Yi-Ming Chiang ◽  
Tzu-Shyang Lin ◽  
Shu-Lin Chang ◽  
Green Ahn ◽  
Clay C. C. Wang
Keyword(s):  
Natural Products ◽  
Aspergillus Nidulans ◽  
Fungal Natural Products

Fungal natural products targeting chronic lymphocytic leukemia

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
T Thorskov Bladt ◽  
S Kildgaard ◽  
P Boldsen Knudsen ◽  
C Held Gotfredsen ◽  
C Dürr ◽  
...  
Keyword(s):  
Natural Products ◽  
Chronic Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Fungal Natural Products

scholarly journals Core Steps to the Azaphilone Family of Fungal Natural Products

ChemBioChem ◽  
2021 ◽  
Author(s):  
Katherine Williams ◽  
Claudio Greco ◽  
Andrew M. Bailey ◽  
Christine L. Willis
Keyword(s):  
Natural Products ◽  
Fungal Natural Products

scholarly journals MeFSAT: a curated natural product database specific to secondary metabolites of medicinal fungi

RSC Advances ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 2596-2607
Author(s):  
R. P. Vivek-Ananth ◽  
Ajaya Kumar Sahoo ◽  
Kavyaa Kumaravel ◽  
Karthikeyan Mohanraj ◽  
Areejit Samal
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Natural Product ◽  
Chemical Space ◽  
Therapeutic Uses ◽  
Medicinal Fungi ◽  
Fungal Natural Products

First dedicated manually curated resource on secondary metabolites and therapeutic uses of medicinal fungi. Cheminformatics based analysis of the chemical space of fungal natural products.

Fungal natural products in research and development

2014 ◽  
Vol 31 (10) ◽  
pp. 1425-1448 ◽  
Author(s):  
Anja Schueffler ◽  
Timm Anke
Keyword(s):  
Natural Products ◽  
Research And Development ◽  
Fungal Natural Products

scholarly journals Biosynthetic investigation of phomopsins reveals a widespread pathway for ribosomal natural products in Ascomycetes

2016 ◽  
Vol 113 (13) ◽  
pp. 3521-3526 ◽  
Author(s):  
Wei Ding ◽  
Wan-Qiu Liu ◽  
Youli Jia ◽  
Yongzhen Li ◽  
Wilfred A. van der Donk ◽  
...  
Keyword(s):  
Natural Products ◽  
Biological Activities ◽  
Genome Mining ◽  
Substrate Specificities ◽  
Modified Peptides ◽  
Fungal Natural Products ◽  
Different Strains

Production of ribosomally synthesized and posttranslationally modified peptides (RiPPs) has rarely been reported in fungi, even though organisms of this kingdom have a long history as a prolific source of natural products. Here we report an investigation of the phomopsins, antimitotic mycotoxins. We show that phomopsin is a fungal RiPP and demonstrate the widespread presence of a pathway for the biosynthesis of a family of fungal cyclic RiPPs, which we term dikaritins. We characterize PhomM as an S-adenosylmethionine–dependent α-N-methyltransferase that converts phomopsin A to anN,N-dimethylated congener (phomopsin E), and show that the methyltransferases involved in dikaritin biosynthesis have evolved differently and likely have broad substrate specificities. Genome mining studies identified eight previously unknown dikaritins in different strains, highlighting the untapped capacity of RiPP biosynthesis in fungi and setting the stage for investigating the biological activities and unknown biosynthetic transformations of this family of fungal natural products.

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