scholarly journals Inhibition of Severe Acute Respiratory Syndrome Coronavirus 2 Replication by Hypertonic Saline Solution in Lung and Kidney Epithelial Cells

2021 ◽  
Vol 4 (5) ◽  
pp. 1514-1527
Author(s):  
Rafael R. G. Machado ◽  
Talita Glaser ◽  
Danielle B. Araujo ◽  
Lyvia Lintzmaier Petiz ◽  
Danielle B. L. Oliveira ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Severe Acute Respiratory Syndrome ◽  
Hypertonic Saline ◽  
Saline Solution ◽  
Hypertonic Saline Solution ◽  
Kidney Epithelial Cells ◽  
Lung And Kidney

Hypertonic saline solution stimulated CLC-3 production in primary cultured human nasal epithelial cells

2008 ◽  
Vol 35 (1) ◽  
pp. 47-51
Author(s):  
Hua-bin Li ◽  
Jian-bo Shi ◽  
Fang Cao ◽  
Lei Cheng ◽  
Wei-ping Wen ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Hypertonic Saline ◽  
Saline Solution ◽  
Hypertonic Saline Solution ◽  
Nasal Epithelial Cells ◽  
Human Nasal Epithelial Cells

scholarly journals Lidocaine coinfusion alleviates vascular pain induced by hypertonic saline infusion: a randomized, placebo-controlled trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zhiping Song ◽  
Shibiao Chen ◽  
Yang Zhang ◽  
Xiaoyun Shi ◽  
Na Zhao ◽  
...  
Keyword(s):  
Hypertonic Saline ◽  
Saline Solution ◽  
Time Slot ◽  
Controlled Trial ◽  
Saline Infusion ◽  
Clinical Trial Registry ◽  
Hypertonic Saline Solution ◽  
Vas Scores ◽  
Vascular Pain ◽  
Hypertonic Saline Infusion

Abstract Background Hypertonic saline solution has been frequently utilized in clinical practice. However, due to the nonphysiological osmolality, hypertonic saline infusion usually induces local vascular pain. We conducted this study to evaluate the effect of lidocaine coinfusion for alleviating vascular pain induced by hypertonic saline. Methods One hundred and six patients undergoing hypertonic saline volume preloading prior to spinal anesthesia were randomly allocated to two groups of 53 each. Group L received a 1 mg/kg lidocaine bolus followed by infusion of 2 mg/kg/h through the same IV line during hypertonic saline infusion; Group C received a bolus and infusion of normal saline of equivalent volume. Visual analogue scale (VAS) scores of vascular pain were recorded every 4 min. Results The vascular pain severity in Group L was significantly lower than that in Group C for each time slot (P < 0.05). The overall incidence of vascular pain during hypertonic saline infusion in Group L was 48.0%, which was significantly lower than the incidence (79.6%) in Group C (P < 0.05). Conclusion Lidocaine coinfusion could effectively alleviate vascular pain induced by hypertonic saline infusion. Trial registration Chinese Clinical Trial Registry, number: ChiCTR1900023753. Registered on 10 June 2019.

scholarly journals Hypertonic Saline Solution Drives Neutrophil from Bystander Organ to Infectious Site in Polymicrobial Sepsis: A Cecal Ligation and Puncture Model

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e74369 ◽  
Author(s):  
Mariana Cardillo Theobaldo ◽  
Flavia Llimona ◽  
Ricardo Costa Petroni ◽  
Ester Correia Sarmento Rios ◽  
Irineu Tadeu Velasco ◽  
...  
Keyword(s):  
Hypertonic Saline ◽  
Saline Solution ◽  
Cecal Ligation ◽  
Polymicrobial Sepsis ◽  
Cecal Ligation And Puncture ◽  
Hypertonic Saline Solution ◽  
Puncture Model

scholarly journals Biphasic ENaC regulation by IKKβ in lung and kidney epithelial cells

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Kenneth R. Hallows ◽  
Rodrigo Alzamora ◽  
Preston Goodson ◽  
Christy Smolak ◽  
Nuria M. Pastor‐Soler ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Kidney Epithelial Cells ◽  
Lung And Kidney
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