scholarly journals Control and Preparation of Quaternized Chitosan and Carboxymethyl Chitosan Nanoscale Polyelectrolyte Complexes Based on Reactive Flash Nanoprecipitation

ACS Omega ◽  
2021 ◽  
Author(s):  
Rizwan Ahmed Bhutto ◽  
Noor ul ain Hira ◽  
Zhinan Fu ◽  
Mingwei Wang ◽  
Adeel Halepoto ◽  
...  
Keyword(s):  
Carboxymethyl Chitosan ◽  
Flash Nanoprecipitation ◽  
Polyelectrolyte Complexes ◽  
Quaternized Chitosan

scholarly journals pH-Sensitive Alginate/Carboxymethyl Chitosan/Aminated Chitosan Microcapsules for Efficient Encapsulation and Delivery of Diclofenac Sodium

Pharmaceutics ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 338
Author(s):  
Ahmed M. Omer ◽  
Maha S. Ahmed ◽  
Gehan M. El-Subruiti ◽  
Randa E. Khalifa ◽  
Abdelazeem S. Eltaweil
Keyword(s):  
Drug Carrier ◽  
Diclofenac Sodium ◽  
Gastric Fluid ◽  
Carboxymethyl Chitosan ◽  
Ph Sensitive ◽  
Simulated Gastric Fluid ◽  
Burst Release ◽  
Polyelectrolyte Complexes ◽  
Thermogravimetric Analyzer ◽  
Ft Ir

To develop an effective pH-sensitive drug carrier, alginate (Alg), carboxymethyl chitosan (CMCs), and aminated chitosan (AmCs) derivatives were employed in this study. A simple ionic gelation technique was employed to formulate Alg-CMCs@AmCs dual polyelectrolyte complexes (PECs) microcapsules as a pH-sensitive carrier for efficient encapsulation and release of diclofenac sodium (DS) drug. The developed microcapsules were characterized by Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analyzer (TGA), and scanning electron microscope (SEM). The results clarified that formation of dual PECs significantly protected Alg microcapsules from rapid disintegration at colon conditions (pH 7.4), and greatly reduced their porosity. In addition, the dual PECs microcapsules can effectively encapsulate 95.4% of DS-drug compared to 86.3 and 68.6% for Alg and Alg-CMCs microcapsules, respectively. Higher DS-release values were achieved in simulated colonic fluid [SCF; pH 7.4] compared to those obtained in simulated gastric fluid [SGF; pH 1.2]. Moreover, the drug burst release was prevented and a sustained DS-release was achieved as the AmCs concentration increased. The results confirmed also that the developed microcapsules were biodegradable in the presence of the lysozyme enzyme. These findings emphasize that the formulated pH-sensitive microcapsules could be applied for the delivery of diclofenac sodium.

Novel antibacterial electrospun materials based on polyelectrolyte complexes of a quaternized chitosan derivative

RSC Advances ◽  
2015 ◽  
Vol 5 (67) ◽  
pp. 54517-54526 ◽  
Author(s):  
Kalin N. Kalinov ◽  
Milena G. Ignatova ◽  
Nevena E. Manolova ◽  
Nadya D. Markova ◽  
Daniela B. Karashanova ◽  
...  
Keyword(s):  
Acrylic Acid ◽  
Chitosan Derivative ◽  
Polyelectrolyte Complexes ◽  
Antibacterial Materials ◽  
Quaternized Chitosan ◽  
Poly Acrylic Acid

Novel antibacterial materials based on polyelectrolyte complexes of quaternized chitosan (TMCh) and poly(2-acrylamido-2-methylpropanesulfonic acid) or poly(acrylic acid) (PAA) were prepared by electrospinning. AgNPs were loaded in TMCh/PAA fibers.

Preparation and characterization of O-carboxymethyl chitosan–sodium alginate polyelectrolyte complexes

2014 ◽  
Vol 293 (2) ◽  
pp. 401-407 ◽  
Author(s):  
Guo-Qing Huang ◽  
Ling-Yun Cheng ◽  
Jun-Xia Xiao ◽  
Xiao-Na Han
Keyword(s):  
Sodium Alginate ◽  
Carboxymethyl Chitosan ◽  
Polyelectrolyte Complexes

Plasma Contact Activation and Decrease of Factor V Activity on Negatively-Charged Polyelectrolytes

1984 ◽  
Vol 51 (01) ◽  
pp. 061-064 ◽  
Author(s):  
M C Boffa ◽  
B Dreyer ◽  
C Pusineri
Keyword(s):  
Time Dependent ◽  
Initial Contact ◽  
Factor Xii ◽  
Factor V ◽  
Contact Activation ◽  
Polyelectrolyte Complexes ◽  
Plasma Factor ◽  
Fresh Plasma ◽  
Direct Adsorption

SummaryThe effect of negatively-charged polymers, used in some artificial devices, on plasma clotting and kinin systems was studied in vitro using polyelectrolyte complexes.Contact activation was observed as an immediate, transient and surface-dependent phenomenon. After incubation of the plasma with the polymer a small decrease of factor XII activity was noticed, which corresponded to a greater reduction of prekallikrein activity and to a marked kinin release. No significant decrease of factor XII, prekallikrein, HMW kininogen could be detected immunologically. Only the initial contact of the plasma with the polyelectrolyte lead to activation, subsequently the surface became inert.Beside contact activation, factor V activity also decreased in the plasma. The decrease was surface and time-dependent. It was independent of contact factor activation, and appeared to be related to the sulfonated groups of the polymer. If purified factor V was used instead of plasma factor V, inactivation was immediate and not time-dependent suggesting a direct adsorption on the surface. A second incubation of the plasma-contacted polymer with fresh plasma resulted in a further loss of Factor V activity.

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