scholarly journals Surface Tethering of Inflammation-Modulatory Nanostimulators to Stem Cells for Ischemic Muscle Repair

ACS Nano ◽  
2020 ◽  
Vol 14 (5) ◽  
pp. 5298-5313 ◽  
Author(s):  
Jiayu Leong ◽  
Yu-Tong Hong ◽  
Yu-Fu Wu ◽  
Eunkyung Ko ◽  
Svyatoslav Dvoretskiy ◽  
...  
Keyword(s):  
Stem Cells ◽  
Muscle Repair ◽  
Ischemic Muscle

scholarly journals Therapeutic potential of adipose-derived stem cells and macrophages for ischemic skeletal muscle repair

2017 ◽  
Vol 12 (2) ◽  
pp. 153-167 ◽  
Author(s):  
Viktoriya Rybalko ◽  
Pei-Ling Hsieh ◽  
Laura M Ricles ◽  
Eunna Chung ◽  
Roger P Farrar ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Therapeutic Potential ◽  
Adipose Derived Stem Cells ◽  
Muscle Repair

scholarly journals Coaxing stem cells for skeletal muscle repair

2015 ◽  
Vol 84 ◽  
pp. 198-207 ◽  
Author(s):  
Karl J.A. McCullagh ◽  
Rita C.R. Perlingeiro
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Muscle Repair

scholarly journals Trends in Mesenchymal Stem Cells' Applications for Skeletal Muscle Repair and Regeneration

10.5772/60919 ◽  
2015 ◽  
Author(s):  
A.R. Caseiro ◽  
T. Pereira ◽  
P.J. Bártolo ◽  
J.D. Santos ◽  
A.L. Luís ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Muscle Repair

scholarly journals Stem cells for skeletal muscle repair

2011 ◽  
Vol 366 (1575) ◽  
pp. 2297-2306 ◽  
Author(s):  
Jennifer L. Shadrach ◽  
Amy J. Wagers
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Satellite Cell ◽  
Satellite Cells ◽  
Cell Function ◽  
Therapeutic Potential ◽  
Muscle Disease ◽  
Muscle Fibres ◽  
Muscle Repair ◽  
Muscle Satellite Cells

Skeletal muscle is a highly specialized tissue composed of non-dividing, multi-nucleated muscle fibres that contract to generate force in a controlled and directed manner. Skeletal muscle is formed during embryogenesis from a subset of muscle precursor cells, which generate both differentiated muscle fibres and specialized muscle-forming stem cells known as satellite cells. Satellite cells remain associated with muscle fibres after birth and are responsible for muscle growth and repair throughout life. Failure in satellite cell function can lead to delayed, impaired or failed recovery after muscle injury, and such failures become increasingly prominent in cases of progressive muscle disease and in old age. Recent progress in the isolation of muscle satellite cells and elucidation of the cellular and molecular mediators controlling their activity indicate that these cells represent promising therapeutic targets. Such satellite cell-based therapies may involve either direct cell replacement or development of drugs that enhance endogenous muscle repair mechanisms. Here, we discuss recent breakthroughs in understanding both the cell intrinsic and extrinsic regulators that determine the formation and function of muscle satellite cells, as well as promising paths forward to realizing their full therapeutic potential.

scholarly journals Surface tethering of stromal cell-derived factor-1α carriers to stem cells enhances cell homing to ischemic muscle

2020 ◽  
Vol 28 ◽  
pp. 102215
Author(s):  
Jye Yng Teo ◽  
Eunkyung Ko ◽  
Jiayu Leong ◽  
Jiman Hong ◽  
Jessie S. Jeon ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stromal Cell ◽  
Cell Homing ◽  
Stromal Cell Derived Factor ◽  
Ischemic Muscle

scholarly journals Rejuvenating stem cells to restore muscle regeneration in aging

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 76 ◽  
Author(s):  
Eyal Bengal ◽  
Eusebio Perdiguero ◽  
Antonio L. Serrano ◽  
Pura Muñoz-Cánoves
Keyword(s):  
Stem Cells ◽  
Satellite Cell ◽  
Satellite Cells ◽  
Environmental Changes ◽  
Local Environment ◽  
The Elderly ◽  
Muscle Repair ◽  
Extrinsic Factors ◽  
Repair Capacity ◽  
Cell Dysfunction

Adult muscle stem cells, originally called satellite cells, are essential for muscle repair and regeneration throughout life. Besides a gradual loss of mass and function, muscle aging is characterized by a decline in the repair capacity, which blunts muscle recovery after injury in elderly individuals. A major effort has been dedicated in recent years to deciphering the causes of satellite cell dysfunction in aging animals, with the ultimate goal of rejuvenating old satellite cells and improving muscle function in elderly people. This review focuses on the recently identified network of cell-intrinsic and -extrinsic factors and processes contributing to the decline of satellite cells in old animals. Some studies suggest that aging-related satellite-cell decay is mostly caused by age-associated extrinsic environmental changes that could be reversed by a “youthful environment”. Others propose a central role for cell-intrinsic mechanisms, some of which are not reversed by environmental changes. We believe that these proposals, far from being antagonistic, are complementary and that both extrinsic and intrinsic factors contribute to muscle stem cell dysfunction during aging-related regenerative decline. The low regenerative potential of old satellite cells may reflect the accumulation of deleterious changes during the life of the cell; some of these changes may be inherent (intrinsic) while others result from the systemic and local environment (extrinsic). The present challenge is to rejuvenate aged satellite cells that have undergone reversible changes to provide a possible approach to improving muscle repair in the elderly.

scholarly journals Pro-myogenic small molecules revealed by a chemical screen on primary muscle stem cells

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Sean M. Buchanan ◽  
Feodor D. Price ◽  
Alessandra Castiglioni ◽  
Amanda Wagner Gee ◽  
Joel Schneider ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Stem Cell ◽  
Small Molecules ◽  
Satellite Cell ◽  
Satellite Cells ◽  
Muscle Repair ◽  
Muscle Stem Cells

Abstract Satellite cells are the canonical muscle stem cells that regenerate damaged skeletal muscle. Loss of function of these cells has been linked to reduced muscle repair capacity and compromised muscle health in acute muscle injury and congenital neuromuscular diseases. To identify new pathways that can prevent loss of skeletal muscle function or enhance regenerative potential, we established an imaging-based screen capable of identifying small molecules that promote the expansion of freshly isolated satellite cells. We found several classes of receptor tyrosine kinase (RTK) inhibitors that increased freshly isolated satellite cell numbers in vitro. Further exploration of one of these compounds, the RTK inhibitor CEP-701 (also known as lestaurtinib), revealed potent activity on mouse satellite cells both in vitro and in vivo. This expansion potential was not seen upon exposure of proliferating committed myoblasts or non-myogenic fibroblasts to CEP-701. When delivered subcutaneously to acutely injured animals, CEP-701 increased both the total number of satellite cells and the rate of muscle repair, as revealed by an increased cross-sectional area of regenerating fibers. Moreover, freshly isolated satellite cells expanded ex vivo in the presence of CEP-701 displayed enhanced muscle engraftment potential upon in vivo transplantation. We provide compelling evidence that certain RTKs, and in particular RET, regulate satellite cell expansion during muscle regeneration. This study demonstrates the power of small molecule screens of even rare adult stem cell populations for identifying stem cell-targeting compounds with therapeutic potential.

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