scholarly journals Manipulating the Topology of Nanoscale Skyrmion Bubbles by Spatially Geometric Confinement

ACS Nano ◽  
2019 ◽  
Vol 13 (1) ◽  
pp. 922-929 ◽  
Author(s):  
Zhipeng Hou ◽  
Qiang Zhang ◽  
Guizhou Xu ◽  
Senfu Zhang ◽  
Chen Gong ◽  
...  
Keyword(s):  
Geometric Confinement

scholarly journals Morphodynamic signatures of MDA-MB-231 single cells and cell doublets undergoing invasion in confined microenvironments

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xingjian Zhang ◽  
Trevor Chan ◽  
Michael Mak
Keyword(s):  
Single Cell ◽  
Single Cells ◽  
Leading Edge ◽  
Cell Group ◽  
Collective State ◽  
Long Term Effects ◽  
Cell Metastasis ◽  
Geometric Confinement ◽  
Short And Long Term ◽  
The Impact

AbstractCancer cell metastasis is a major factor in cancer-related mortality. During the process of metastasis, cancer cells exhibit migratory phenotypes and invade through pores in the dense extracellular matrix. However, the characterization of morphological and subcellular features of cells in similar migratory phenotypes and the effects of geometric confinement on cell morphodynamics are not well understood. Here, we investigate the phenotypes of highly aggressive MDA-MB-231 cells in single cell and cell doublet (an initial and simplified collective state) forms in confined microenvironments. We group phenotypically similar single cells and cell doublets and characterize related morphological and subcellular features. We further detect two distinct migratory phenotypes, fluctuating and non-fluctuating, within the fast migrating single cell group. In addition, we demonstrate an increase in the number of protrusions formed at the leading edge of cells after invasion through geometric confinement. Finally, we track the short and long term effects of varied degrees of confinement on protrusion formation. Overall, our findings elucidate the underlying morphological and subcellular features associated with different single cell and cell doublet phenotypes and the impact of invasion through confined geometry on cell behavior.

scholarly journals The effect of geometric confinement on gas separation characteristics of additive poly[3-(trimethylsilyl)tricyclononene-7]

2018 ◽  
Vol 9 (2) ◽  
pp. 252-258
Author(s):  
E.A. Chernova ◽  
M.A. Bermeshev ◽  
D.I. Petukhov ◽  
O.V. Boytsova ◽  
A.V. Lukashin ◽  
...  
Keyword(s):  
Gas Separation ◽  
Geometric Confinement

scholarly journals Geometric confinement is required for recovery and maintenance of chondrocyte phenotype in alginate

2017 ◽  
Vol 1 (1) ◽  
pp. 016104 ◽  
Author(s):  
Megan E. Cooke ◽  
Mark J. Pearson ◽  
Richard J. A. Moakes ◽  
Christopher J. Weston ◽  
Edward T. Davis ◽  
...  
Keyword(s):  
Chondrocyte Phenotype ◽  
Geometric Confinement

Cell Motility in Microfabricated Models of the Tissue Microenvironment

2001 ◽  
Author(s):  
Kevin Kit Parker ◽  
Donald E. Ingber
Keyword(s):  
Cell Motility ◽  
Signaling Pathways ◽  
Intracellular Signaling ◽  
Isometric Tension ◽  
Migration Behavior ◽  
Tissue Microenvironment ◽  
Intracellular Signaling Pathways ◽  
Capillary Endothelial Cells ◽  
Geometric Confinement ◽  
Stable Rotation

Abstract We conducted studies using micropatterned substrates to elucidate how cell shape and geometric confinement regulates the inter- and intracellular signaling pathways required for cell motility. When cells were cultured on individual cell-sized square adhesive islands coated with ECM, they extend to the edge of the island and assume a square shape. When these cells were stimulated with growth factors, they preferentially extended lamellipodia from the corners versus the sides. This process was mediated by myosin-generated isometric tension that induced tight spatial localization of Rac in the corners. When two or three capillary endothelial cells are constrained to a fibronectin (FN) island, coordinated cell migration results in stable rotation of the entire system about its center. Thus, the emergent pattern is due to the coordinated migration behavior of the cells. These observations suggest that ECM-induced mechanotransduction potentiates compartmentalized signaling pathways and the multicellular organization required of tissue morphogenesis.

Self-Assembled Fe3O4 Nanoparticle Clusters as High-Performance Anodes for Lithium Ion Batteries via Geometric Confinement

Nano Letters ◽  
2013 ◽  
Vol 13 (9) ◽  
pp. 4249-4256 ◽  
Author(s):  
Soo Hong Lee ◽  
Seung-Ho Yu ◽  
Ji Eun Lee ◽  
Aihua Jin ◽  
Dong Jun Lee ◽  
...  
Keyword(s):  
Lithium Ion Batteries ◽  
High Performance ◽  
Lithium Ion ◽  
Fe3o4 Nanoparticle ◽  
Nanoparticle Clusters ◽  
Geometric Confinement ◽  
Self Assembled

Active particles under confinement and effective force generation among surfaces

Soft Matter ◽  
2018 ◽  
Vol 14 (44) ◽  
pp. 9044-9054 ◽  
Author(s):  
Lorenzo Caprini ◽  
Umberto Marini Bettolo Marconi
Keyword(s):  
Steady State ◽  
Thermal Noise ◽  
Active Suspension ◽  
Force Generation ◽  
One Dimensional ◽  
Effective Force ◽  
Active Particles ◽  
Geometric Confinement

We consider the effect of geometric confinement on the steady-state properties of a one-dimensional active suspension subject to thermal noise.

scholarly journals Stochastic geometry sensing and polarization in a lipid kinase–phosphatase competitive reaction

2019 ◽  
Vol 116 (30) ◽  
pp. 15013-15022 ◽  
Author(s):  
Scott D. Hansen ◽  
William Y. C. Huang ◽  
Young Kwang Lee ◽  
Peter Bieling ◽  
Sune M. Christensen ◽  
...  
Keyword(s):  
Membrane Composition ◽  
Competitive Reaction ◽  
Lipid Kinase ◽  
Signaling Systems ◽  
Membrane Surfaces ◽  
Stochastic Fluctuations ◽  
Spatial Composition ◽  
Cellular Signal ◽  
Geometric Confinement ◽  
Phosphatidylinositol 4

Phosphorylation reactions, driven by competing kinases and phosphatases, are central elements of cellular signal transduction. We reconstituted a native eukaryotic lipid kinase–phosphatase reaction that drives the interconversion of phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-phosphate [PI(4,5)P2] on membrane surfaces. This system exhibited bistability and formed spatial composition patterns on supported membranes. In smaller confined regions of membrane, rapid diffusion ensures the system remains spatially homogeneous, but the final outcome—a predominantly PI(4)P or PI(4,5)P2 membrane composition—was governed by the size of the reaction environment. In larger confined regions, interplay between the reactions, diffusion, and confinement created a variety of differentially patterned states, including polarization. Experiments and kinetic modeling reveal how these geometric confinement effects arise from a mechanism based on stochastic fluctuations in the copy number of membrane-bound kinases and phosphatases. The underlying requirements for such behavior are unexpectedly simple and likely to occur in natural biological signaling systems.

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