Rational Design of Cancer Nanomedicine for Simultaneous Stealth Surface and Enhanced Cellular Uptake

ACS Nano ◽  
2019 ◽  
Author(s):  
Qiao Jin ◽  
Yongyan Deng ◽  
Xiaohui Chen ◽  
Jian Ji
Keyword(s):  
Cellular Uptake ◽  
Rational Design ◽  
Cancer Nanomedicine

scholarly journals Understanding Nanoparticle Toxicity to Direct a Safe-by-Design Approach in Cancer Nanomedicine

Nanomaterials ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 2186 ◽  
Author(s):  
Jossana A. Damasco ◽  
Saisree Ravi ◽  
Joy D. Perez ◽  
Daniel E. Hagaman ◽  
Marites P. Melancon
Keyword(s):  
Heavy Metals ◽  
Physicochemical Properties ◽  
Tumor Targeting ◽  
Rational Design ◽  
Inorganic Materials ◽  
Cancer Therapies ◽  
Inorganic Nanoparticle ◽  
Treatment And Prevention ◽  
Cancer Nanomedicine ◽  
Safe By Design

Nanomedicine is a rapidly growing field that uses nanomaterials for the diagnosis, treatment and prevention of various diseases, including cancer. Various biocompatible nanoplatforms with diversified capabilities for tumor targeting, imaging, and therapy have materialized to yield individualized therapy. However, due to their unique properties brought about by their small size, safety concerns have emerged as their physicochemical properties can lead to altered pharmacokinetics, with the potential to cross biological barriers. In addition, the intrinsic toxicity of some of the inorganic materials (i.e., heavy metals) and their ability to accumulate and persist in the human body has been a challenge to their translation. Successful clinical translation of these nanoparticles is heavily dependent on their stability, circulation time, access and bioavailability to disease sites, and their safety profile. This review covers preclinical and clinical inorganic-nanoparticle based nanomaterial utilized for cancer imaging and therapeutics. A special emphasis is put on the rational design to develop non-toxic/safe inorganic nanoparticle constructs to increase their viability as translatable nanomedicine for cancer therapies.

Surface-Engineered Cancer Nanomedicine: Rational Design and Recent Progress

2020 ◽  
Vol 26 (11) ◽  
pp. 1181-1190 ◽  
Author(s):  
Javed Ahmad ◽  
Ameeduzzafar ◽  
Mohammad Z. Ahmad ◽  
Habban Akhter
Keyword(s):  
Drug Targeting ◽  
Rational Design ◽  
Recent Progress ◽  
Surface Engineering ◽  
Drug Efficacy ◽  
Functional Materials ◽  
Inorganic Materials ◽  
Cancer Chemotherapeutics ◽  
Cancer Nanomedicine ◽  
Diagnostic Agents

: Cancer is highly heterogeneous in nature and characterized by abnormal, uncontrolled cells’ growth. It is responsible for the second leading cause of death in the world. Nanotechnology is explored profoundly for sitespecific delivery of cancer chemotherapeutics as well as overcome multidrug-resistance (MDR) challenges in cancer. The progress in the design of various smart biocompatible materials (such as polymers, lipids and inorganic materials) has now revolutionized the area of cancer research for the rational design of nanomedicine by surface engineering with targeting ligands. The small tunable size and surface properties of nanomedicines provide the opportunity of multiple payloads and multivalent-ligand targeting to achieve drug efficacy even in MDR cancer. Furthermore, efforts are being carried out for the development of novel nano-pharmaceutical design, focusing on the delivery of therapeutic and diagnostic agents simultaneously which is called theranostics to assess the progress of therapy in cancer. This review aimed to discuss the physicochemical manipulation of cancer nanomedicine for rational design and recent progress in the area of surface engineering of nanomedicines to improve the efficacy of cancer chemotherapeutics in MDR cancer as well. Moreover, the problem of toxicity of the advanced functional materials that are used in nanomedicines and are exploited to achieve drug targeting in cancer is also addressed.

Tuning Cellular Uptake of Molecular Probes by Rational Design of Their Assembly into Supramolecular Nanoprobes

2016 ◽  
Vol 138 (10) ◽  
pp. 3533-3540 ◽  
Author(s):  
Lye Lin Lock ◽  
Claudia D. Reyes ◽  
Pengcheng Zhang ◽  
Honggang Cui
Keyword(s):  
Cellular Uptake ◽  
Rational Design ◽  
Molecular Probes

Rational Design of Surface-State Controlled Multicolor Cross-Linked Carbon Dots with Distinct Photoluminescence and Cellular Uptake Properties

2021 ◽  
Author(s):  
Indrajit Srivastava ◽  
Parikshit Moitra ◽  
Muhammad Fayyaz ◽  
Subhendu Pandit ◽  
Taylor L. Kampert ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Surface State ◽  
Carbon Dots ◽  
Rational Design

Rational design and fabrication of a cancer-targeted chitosan nanocarrier to enhance selective cellular uptake and anticancer efficacy of selenocystine

2015 ◽  
Vol 3 (12) ◽  
pp. 2497-2504 ◽  
Author(s):  
Bo Yu ◽  
Hong Li ◽  
Jinhui Zhang ◽  
Wenjie Zheng ◽  
Tianfeng Chen
Keyword(s):  
Cellular Uptake ◽  
Rational Design ◽  
Anticancer Efficacy

A cancer-targeted chitosan nanocarrier has been rationally designed to enhance the selective cellular uptake and anticancer efficacy of selenocystine.

How to avoid protein aggregation to improve cellular uptake of albumin-based conjugates: towards the rational design of cell-penetrable phosphorescent probes

2018 ◽  
Vol 297 (3) ◽  
pp. 325-337 ◽  
Author(s):  
Anastasia I. Solomatina ◽  
Vadim A. Baigildin ◽  
Daniil D. Zhukovsky ◽  
Dmitrii V. Krupenya ◽  
Elena I. Koshel ◽  
...  
Keyword(s):  
Protein Aggregation ◽  
Cellular Uptake ◽  
Rational Design

Rational Design of Cancer Nanomedicine: Nanoproperty Integration and Synchronization

2017 ◽  
Vol 29 (14) ◽  
pp. 1606628 ◽  
Author(s):  
Qihang Sun ◽  
Zhuxian Zhou ◽  
Nasha Qiu ◽  
Youqing Shen
Keyword(s):  
Rational Design ◽  
Cancer Nanomedicine

scholarly journals DePEGylation strategies to increase cancer nanomedicine efficacy

2019 ◽  
Vol 4 (2) ◽  
pp. 378-387 ◽  
Author(s):  
Li Kong ◽  
Frederick Campbell ◽  
Alexander Kros
Keyword(s):  
Drug Delivery ◽  
Cellular Uptake ◽  
Stimuli Responsive ◽  
Concomitant Drug ◽  
Cancer Nanomedicine ◽  
The Cost

PEGylation of nanoparticles prolongs circulation lifetimes and maximizes nanoparticle accumulation in target tumors. However, PEGylation comes at the cost of reduced cellular uptake of nanoparticles and concomitant drug delivery. This review discusses the various stimuli-responsive dePEGylation strategies that have been employed to overcome this “PEG dilemma”.

scholarly journals Rapid transport of germ-mimetic nanoparticles with dual conformational polyethylene glycol chains in biological tissues

2020 ◽  
Vol 6 (6) ◽  
pp. eaay9937
Author(s):  
Yiwei Yang ◽  
Falin Tian ◽  
Di Nie ◽  
Yuan Liu ◽  
Kun Qian ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Rational Design ◽  
Biological Tissues ◽  
Polymer Conformation ◽  
Tumor Tissues ◽  
Rapid Transport ◽  
Adhesive Interactions ◽  
Crystalline Drugs

Polyethylene glycols (PEGs) can improve the diffusivity of nanoparticles (NPs) in biological hydrogels, while extended PEG chains severely impede cellular uptake of NPs. Inspired by invasive germs with flagellum-driven mucus-penetrating and fimbriae-mediated epithelium-adhering abilities, we developed germ-mimetic NPs (GMNPs) to overcome multiple barriers in mucosal and tumor tissues. In vitro studies and computational simulations revealed that the tip-specific extended PEG chains on GMNP functioned similarly to flagella, facilitating GMNP diffusion (up to 83.0-fold faster than their counterparts). Meanwhile, the packed PEG chains on the bodies of GMNP mediated strong adhesive interactions with cells similarly to the fimbriae, preserving cellular uptake efficiency. The in vivo results proved the superior tumor permeability and improved oral bioavailability provided by the GMNP (21.9-fold over administration of crystalline drugs). These findings offer useful guidelines for the rational design of NPs by manipulating surface polymer conformation to realize multiple functions and to enhance delivery efficacy.

Size changeable nanosystems for precise drug controlled release and efficient overcoming of cancer multidrug resistance

2017 ◽  
Vol 5 (5) ◽  
pp. 944-952 ◽  
Author(s):  
Xueyang Fang ◽  
Wenting Jiang ◽  
Yanyu Huang ◽  
Fang Yang ◽  
Tianfeng Chen
Keyword(s):  
Multidrug Resistance ◽  
Controlled Release ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Rational Design ◽  
Drug Controlled Release

Herein we demonstrate the rational design of a size changeable nanosystem for precise drug controlled release and efficient overcoming of cancer multidrug resistance in cancer cells by enhancing the cellular uptake and inhibiting the expression of ABC family proteins.

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