Synthetic Cargo Internalization Receptor System for Nanoparticle Tracking of Individual Cell Populations by Fluorine Magnetic Resonance Imaging

ACS Nano ◽  
2018 ◽  
Vol 12 (11) ◽  
pp. 11178-11192 ◽  
Author(s):  
Sebastian Temme ◽  
Paul Baran ◽  
Pascal Bouvain ◽  
Christoph Grapentin ◽  
Wolfgang Krämer ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Individual Cell ◽  
Cell Populations ◽  
Resonance Imaging ◽  
Receptor System ◽  
Fluorine Magnetic Resonance Imaging

scholarly journals In Vivo Monitoring of Inflammation After Cardiac and Cerebral Ischemia by Fluorine Magnetic Resonance Imaging

Circulation ◽  
2008 ◽  
Vol 118 (2) ◽  
pp. 140-148 ◽  
Author(s):  
Ulrich Flögel ◽  
Zhaoping Ding ◽  
Hendrik Hardung ◽  
Sebastian Jander ◽  
Gaby Reichmann ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cerebral Ischemia ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
In Vivo Monitoring ◽  
Fluorine Magnetic Resonance Imaging

scholarly journals Concurrent Dual Contrast for Cellular Magnetic Resonance Imaging Using Gadolinium Oxide and Iron Oxide Nanoparticles

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Yasir Loai ◽  
Tameshwar Ganesh ◽  
Hai-Ling Margaret Cheng
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Negative Contrast ◽  
7 Tesla ◽  
Cell Populations ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Mixed Cell ◽  
Fe Oxide

Rationale and Objectives. Concurrent visualization of differential targets in cellular and molecular imaging is valuable for resolving processes spatially and temporally, as in monitoring different cell subtypes. The purpose of this study was to demonstrate concurrent, dual (positive and negative) contrast visualization on magnetic resonance imaging (MRI) of two colocalized cell populations labeled with Gadolinium “Gd” oxide and iron “Fe” oxide nanoparticles. Materials and Methods. Human aortic endothelial cells (EC) and smooth muscle cells (SMC) were labeled with various concentrations of Gd oxide and Fe oxide, respectively. MRI on single- or mixed-cell samples was performed at 7 tesla. Proper cell phenotype expressions, cell uptake of contrast agents, and the effect of labeling on cell viability and proliferation were also determined. Results. Both contrast agents were efficiently taken up by cells, with viability and proliferation largely unaffected. On MRI, the positive contrast associated with Gd oxide-labeled EC and negative contrast associated with Fe oxide-labeled SMC discriminated the presence of each cell type, whether it existed alone or colocalized in a mixed-cell sample. Conclusion. It is feasible to use Gd oxide and Fe oxide for dual contrast and concurrent discrimination of two colocalized cell populations on MRI at 7 tesla.

Clinical Perspectives of Hybrid Proton-Fluorine Magnetic Resonance Imaging and Spectroscopy

2013 ◽  
Vol 48 (5) ◽  
pp. 341-350 ◽  
Author(s):  
Martijn Wolters ◽  
Seyede G. Mohades ◽  
Tilman M. Hackeng ◽  
Mark J. Post ◽  
Marianne E. Kooi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Imaging And Spectroscopy ◽  
Fluorine Magnetic Resonance Imaging

scholarly journals Noninvasive Identification of Viable Cell Populations in Docetaxel-Treated Breast Tumors Using Ferritin-Based Magnetic Resonance Imaging

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e52931 ◽  
Author(s):  
YoonSeok Choi ◽  
Hoe Suk Kim ◽  
Kyoung-Won Cho ◽  
Kyung-Min Lee ◽  
Yoon Jung Yi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Breast Tumors ◽  
Viable Cell ◽  
Cell Populations ◽  
Resonance Imaging ◽  
Treated Breast
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