In vivoandex vivo19-fluorine magnetic resonance imaging and spectroscopy of beta-cells and pancreatic islets using GLUT-2 specific contrast agents

2016 ◽  
Vol 11 (6) ◽  
pp. 506-513 ◽  
Author(s):  
Sayuan Liang ◽  
Karim Louchami ◽  
Hauke Kolster ◽  
Anna Jacobsen ◽  
Ying Zhang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Pancreatic Islets ◽  
Beta Cells ◽  
Resonance Imaging ◽  
Imaging And Spectroscopy ◽  
Fluorine Magnetic Resonance Imaging

Clinical Perspectives of Hybrid Proton-Fluorine Magnetic Resonance Imaging and Spectroscopy

2013 ◽  
Vol 48 (5) ◽  
pp. 341-350 ◽  
Author(s):  
Martijn Wolters ◽  
Seyede G. Mohades ◽  
Tilman M. Hackeng ◽  
Mark J. Post ◽  
Marianne E. Kooi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Imaging And Spectroscopy ◽  
Fluorine Magnetic Resonance Imaging

Chemistry of paramagnetic and diamagnetic contrast agents for Magnetic Resonance Imaging and Spectroscopy

2008 ◽  
Vol 67 (3) ◽  
pp. 453-458 ◽  
Author(s):  
Elena Pérez-Mayoral ◽  
Viviana Negri ◽  
Jordi Soler-Padrós ◽  
Sebastián Cerdán ◽  
Paloma Ballesteros
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Resonance Imaging ◽  
Imaging And Spectroscopy

Supramolecular Enhancement of Aminoxyl ORCA Contrast Agents

2019 ◽  
Author(s):  
Hamilton Lee ◽  
Jenica Lumata ◽  
Michael A. Luzuriaga ◽  
Candace Benjamin ◽  
Olivia Brohlin ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Side Effects ◽  
Magnetic Resonance ◽  
Tobacco Mosaic Virus ◽  
Contrast Agents ◽  
Single Molecule ◽  
Organic Radical ◽  
Resonance Imaging ◽  
Physiological Conditions

<div><div><div><p>Many contrast agents for magnetic resonance imaging are based on gadolinium, however side effects limit their use in some patients. Organic radical contrast agents (ORCAs) are potential alternatives, but are reduced rapidly in physiological conditions and have low relaxivities as single molecule contrast agents. Herein, we use a supramolecular strategy where cucurbit[8]uril binds with nanomolar affinities to ORCAs and protects them against biological reductants to create a stable radical in vivo. We further over came the weak contrast by conjugating this complex on the surface of a self-assembled biomacromolecule derived from the tobacco mosaic virus.</p></div></div></div>

scholarly journals Magnetic resonance thermometry using a GdIII-based contrast agent

2021 ◽  
Vol 57 (14) ◽  
pp. 1770-1773
Author(s):  
S. A. Amali S. Subasinghe ◽  
Jonathan Romero ◽  
Cassandra L. Ward ◽  
Matthew D. Bailey ◽  
Donna R. Zehner ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Resonance Imaging ◽  
Magnetic Resonance Thermometry

The complexes described here serve as contrast agents for magnetic resonance imaging thermometry.

Magnetic Resonance Imaging and Spectroscopy: New Noninvasive In Vivo Approaches in Toxicology Research

1993 ◽  
Vol 21 (4) ◽  
pp. 411-425
Author(s):  
Manfred Brauer
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Fatty Infiltration ◽  
Chronic Ethanol ◽  
Ethanol Administration ◽  
Resonance Imaging ◽  
Human Patient ◽  
Hypoxic Injury ◽  
Imaging And Spectroscopy

Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS) give anatomical and biochemical information about a human patient or animal in a non-invasive manner. This unique quality permits the study of toxicological responses of an organ within an intact animal and in a manner in which many fewer animals are needed than by conventional methods of investigation. The use of MRI and MRS in the study of hepatotoxicants, particularly bromobenzene and ethanol, is reviewed. Bromobenzene causes localised hepatic oedema and bioenergetic deterioration; these changes were followed with time by 1H MRI and 31P MRS, respectively. Phosphocholine levels in the liver were found to increase dramatically during bromobenzene-induced damage, possibly related to an intracellular control mechanism in response to tissue damage. The ability of the bromobenzene-challenged liver to metabolise a fructose load was followed by dynamic 31P MRS. Chronic ethanol administration damages the liver. This toxicological process results in the accumulation of fat in the liver, which was followed by fat-selective 1H MRI. When ethanol is no longer administered to the subject, the fatty infiltration subsides, and this process was followed over 16 days in the same animal using fat-selective 1H MRI. Chronic ethanol renders the liver in situ more susceptible to hypoxic injury and less likely to recover afterwards, as shown by 31P MRS.

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