Targeted Therapy of Atherosclerosis by a Broad-Spectrum Reactive Oxygen Species Scavenging Nanoparticle with Intrinsic Anti-inflammatory Activity

ACS Nano ◽  
2018 ◽  
Vol 12 (9) ◽  
pp. 8943-8960 ◽  
Author(s):  
Yuquan Wang ◽  
Lanlan Li ◽  
Weibo Zhao ◽  
Yin Dou ◽  
Huijie An ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Targeted Therapy ◽  
Broad Spectrum ◽  
Reactive Oxygen ◽  
Inflammatory Activity ◽  
Oxygen Species ◽  
Anti Inflammatory

scholarly journals Proteomic and genetic analysis of the response of S. cerevisiae to soluble copper leads to improvement of the antimicrobial function of cellulosic copper nanoparticles

Metallomics ◽  
2017 ◽  
Vol 9 (9) ◽  
pp. 1304-1315 ◽  
Author(s):  
Xiaoqing Rong-Mullins ◽  
Matthew J. Winans ◽  
Justin B. Lee ◽  
Zachery R. Lonergan ◽  
Vincent A. Pilolli ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Genetic Analysis ◽  
Antimicrobial Agent ◽  
Copper Nanoparticles ◽  
Broad Spectrum ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Antimicrobial Function

Copper (Cu) was used in antiquity to prevent waterborne and food diseases because, as a broad-spectrum antimicrobial agent, it generates reactive oxygen species, ROS.

scholarly journals The Effect of Physical Training on Peripheral Blood Mononuclear Cell Ex Vivo Proliferation, Differentiation, Activity, and Reactive Oxygen Species Production in Racehorses

Antioxidants ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 1155
Author(s):  
Olga Witkowska-Piłaszewicz ◽  
Rafał Pingwara ◽  
Anna Winnicka
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Proliferation ◽  
Immune Cell ◽  
Ex Vivo ◽  
Exercise Physiology ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Peripheral Blood Mononuclear ◽  
Before And After ◽  
Anti Inflammatory

Physical activity has an influence on a variety of processes in an athlete’s organism including the immune system. Unfortunately, there is a lack of studies regarding racehorse immune cells, especially when the horse model is compared to human exercise physiology. The aim of the study was to determine changes in immune cell proliferation, lymphocyte populations, and monocyte functionality in trained and untrained racehorses after exercise. In this study, field data were collected. The cells from 28 racehorses (14 untrained and 14 well-trained) were collected before and after exercise (800 m at a speed of about 800 m/min) and cultured for 4 days. The expression of CD4, CD8, FoxP3, CD14, MHCII, and CD5 in PBMC, and reactive oxygen species (ROS) production, as well as cell proliferation, were evaluated by flow cytometry. In addition, IL-1β, IL-4, IL-6, IL-10, IL-17, INF-γ, and TNF-α concentrations were evaluated by ELISA. The creation of an anti-inflammatory environment in well-trained horses was confirmed. In contrast, a pro-inflammatory reaction occurred in untrained horses after training. In conclusion, an anti-inflammatory state occurs in well-trained racehorses, which is an adaptational reaction to an increased workload during training.

Role of Reactive Oxygen Species and Targeted Therapy in Metastatic Melanoma

2018 ◽  
Vol 4 (1) ◽  
pp. 101-130 ◽  
Author(s):  
Rosalin Mishra ◽  
◽  
Hima Patel ◽  
Long Yuan ◽  
Joan Garrett
Keyword(s):  
Reactive Oxygen Species ◽  
Targeted Therapy ◽  
Metastatic Melanoma ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Alteration of Neutrophil Reactive Oxygen Species Production by Extracts of Devil’s Claw (Harpagophytum)

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Mbaki Muzila ◽  
Kimmo Rumpunen ◽  
Helen Wright ◽  
Helen Roberts ◽  
Melissa Grant ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Respiratory Burst ◽  
Dna Analysis ◽  
Reactive Oxygen ◽  
Human Neutrophils ◽  
Putative Hybrid ◽  
Oxygen Species ◽  
New Variety ◽  
Devil’S Claw ◽  
Anti Inflammatory

Harpagophytum, Devil’s Claw, is a genus of tuberiferous xerophytic plants native to southern Africa. Some of the taxa are appreciated for their medicinal effects and have been traditionally used to relieve symptoms of inflammation. The objectives of this pilot study were to investigate the antioxidant capacity and the content of total phenols, verbascoside, isoverbascoside, and selected iridoids, as well as to investigate the capacity of variousHarpagophytumtaxa in suppressing respiratory burst in terms of reactive oxygen species produced by human neutrophils challenged with phorbol myristate acetate (PMA), opsonisedStaphylococcus aureus,andFusobacterium nucleatum.Harpagophytumplants were classified into different taxa according to morphology, and DNA analysis was used to confirm the classification. A putative new variety ofH. procumbensshowed the highest degree of antioxidative capacity. Using PMA, threeHarpagophytumtaxa showed anti-inflammatory effects with regard to the PBS control. A putative hybrid betweenH. procumbensandH. zeyheriin contrast showed proinflammatory effect on the response of neutrophils toF. nucleatumin comparison with treatment with vehicle control.Harpagophytumtaxa were biochemically very variable and the response in suppressing respiratory burst differed. Further studies with larger number of subjects are needed to corroborate anti-inflammatory effects of different taxa ofHarpagophytum.

z-VAD-fmk augmentation of TNFα-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species

Blood ◽  
2005 ◽  
Vol 105 (7) ◽  
pp. 2970-2972 ◽  
Author(s):  
Andrew S. Cowburn ◽  
Jessica F. White ◽  
John Deighton ◽  
Sarah R. Walmsley ◽  
Edwin R. Chilvers
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Broad Spectrum ◽  
Reactive Oxygen ◽  
Cell Types ◽  
Ros Generation ◽  
Neutrophil Apoptosis ◽  
Oxygen Species ◽  
Caspase Inhibitor ◽  
Induced Apoptosis

Abstract In most cell types constitutive and ligand-induced apoptosis is a caspase-dependent process. In neutrophils, however, the broad-spectrum caspase inhibitor z-VAD-fmk enhances tumor necrosis factor-α (TNFα)-induced cell death, and this has been interpreted as evidence for caspase-dependent and -independent cell death pathways. Our aim was to determine the specificity of the effect of z-VAD-fmk in neutrophils and define the potential mechanism of action. While confirming that z-VAD-fmk (> 100 μM) enhances TNFα-induced neutrophil apoptosis, lower concentrations (1-30 μM) completely blocked TNFα-stimulated apoptosis. Boc-D-fmk, a similar broad-spectrum caspase inhibitor, and z-IETD-fmk, a selective caspase-8 inhibitor, caused a concentration-dependent inhibition of only TNFα-stimulated apoptosis. Moreover, the caspase-9 inhibitor, Ac-LEHD-cmk, had no effect on TNFα-induced apoptosis, and z-VAD-fmk and Boc-D-fmk inhibited TNFα-stimulated reactive oxygen species (ROS) generation. These data suggest that TNFα-induced apoptosis in neutrophils is fully caspase dependent and uses a mitochondrial-independent pathway and that the proapoptotic effects of z-VAD-fmk are compound specific and ROS independent.

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