scholarly journals Age-Dependent Rat Lung Deposition Patterns of Inhaled 20 Nanometer Gold Nanoparticles and their Quantitative Biokinetics in Adult Rats

ACS Nano ◽  
2018 ◽  
Vol 12 (8) ◽  
pp. 7771-7790 ◽  
Author(s):  
Wolfgang G. Kreyling ◽  
Winfried Möller ◽  
Uwe Holzwarth ◽  
Stephanie Hirn ◽  
Alexander Wenk ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Lung Deposition ◽  
Rat Lung ◽  
Adult Rats ◽  
Deposition Patterns ◽  
Age Dependent

scholarly journals Age- and location-dependent differences in store depletion-induced h-channel plasticity in hippocampal pyramidal neurons

2014 ◽  
Vol 111 (6) ◽  
pp. 1369-1382 ◽  
Author(s):  
Ann M. Clemens ◽  
Daniel Johnston
Keyword(s):  
Pyramidal Neurons ◽  
Cyclopiazonic Acid ◽  
Neural Basis ◽  
Adult Rats ◽  
Hippocampal Pyramidal Neurons ◽  
Store Depletion ◽  
Whole Cell Patch Clamp ◽  
Age Dependent ◽  
Adaptive Processes ◽  
Cellular Dysfunction

Disruptions of endoplasmic reticulum (ER) Ca2+ homeostasis are heavily linked to neuronal pathology. Depletion of ER Ca2+ stores can result in cellular dysfunction and potentially cell death, although adaptive processes exist to aid in survival. We examined the age and region dependence of one postulated, adaptive response to ER store-depletion (SD), hyperpolarization-activated cation-nonspecific ( h)-channel plasticity in neurons of the dorsal and ventral hippocampus (DHC and VHC, respectively) from adolescent and adult rats. With the use of whole-cell patch-clamp recordings from the soma and dendrites of CA1 pyramidal neurons, we observed a change in h-sensitive measurements in response to SD, induced by treatment with cyclopiazonic acid, a sarcoplasmic reticulum/ER Ca2+-ATPase blocker. We found that whereas DHC and VHC neurons in adolescent animals respond to SD with a perisomatic expression of SD h plasticity, adult animals express SD h plasticity with a dendritic and somatodendritic locus of plasticity in DHC and VHC neurons, respectively. Furthermore, SD h plasticity in adults was dependent on membrane potential and on the activation of L-type voltage-gated Ca2+ channels. These results suggest that cellular responses to the impairment of ER function, or ER stress, are dependent on brain region and age and that the differential expression of SD h plasticity could provide a neural basis for region- and age-dependent disease vulnerabilities.

Detection of chondroitin sulfates and decorin in developing fetal and neonatal rat lung

2002 ◽  
Vol 282 (3) ◽  
pp. L484-L490 ◽  
Author(s):  
Yiqiong Wang ◽  
Kaori Sakamoto ◽  
Jody Khosla ◽  
Philip L. Sannes
Keyword(s):  
Extracellular Matrix ◽  
Chondroitin Sulfate ◽  
Wide Distribution ◽  
Neonatal Rat ◽  
Chondroitin Sulfate Proteoglycan ◽  
Sulfate Proteoglycan ◽  
Rat Lung ◽  
Adult Rats ◽  
Chondroitin Sulfates ◽  
Monospecific Antibodies

Chondroitin sulfates and their related proteoglycans are components of extracellular matrix that act as key determinants of growth and differentiation characteristics of developing lungs. Changes in their immunohistochemical distribution during progressive organ maturation were examined with monospecific antibodies to chondroitin sulfate, a nonbasement membrane chondroitin sulfate proteoglycan, and the specific chondroitin sulfate-containing proteoglycan decorin in whole fetuses and lungs from newborn and adult rats. Alveolar and airway extracellular matrix immunostained heavily in the prenatal rat for both chondroitin sulfate and chondroitin sulfate proteoglycan, whereas decorin was confined to developing airways and vessels. These sites retained their respective levels of reactivity with all antibodies through 1–10 days postnatal but thereafter became progressively more diminished and focal in alveolar regions. The heavy staining seen early in development was interpreted to reflect a significant and wide distribution of chondroitin sulfates, chondroitin sulfate proteoglycans, and decorin in rapidly growing tissues, whereas the reduced and more focal reactivity observed at later time points coincided with known focal patterns of localization of fibrillar elements of the extracellular matrix and a more differentiated state.

scholarly journals Age-Dependent Translocation of Gold Nanoparticles across the Air–Blood Barrier

ACS Nano ◽  
2019 ◽  
Vol 13 (9) ◽  
pp. 10095-10102 ◽  
Author(s):  
Akira Tsuda ◽  
Thomas C. Donaghey ◽  
Nagarjun V. Konduru ◽  
Georgios Pyrgiotakis ◽  
Laura S. Van Winkle ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Age Dependent

Neuronal Replacement After Traumatic or Age-Dependent Brain Damage

1985 ◽  
Vol 1 (1) ◽  
pp. 93-107
Author(s):  
Anders Björklund ◽  
Fred H. Gage
Keyword(s):  
Research Work ◽  
Adult Rats ◽  
Functional Potential ◽  
Neural Grafts ◽  
Age Dependent ◽  
Long Time ◽  
Tissue Grafts ◽  
And Behavior ◽  
The Brain ◽  
Host Brain

During the last few years evidence has accumulated that fetal neurons, implanted into the depth of the brain in adult rats, can reestablish damaged connections in the host brain and substitute functionally for elements lost or damaged as a result of a preceding lesion. This research work has led to the realization that, contrary to traditional views, the adult mammalian CNS has a potential to incorporate new neuronal elements into already established neuronal circuitry and that such implanted neurons can modify the function and behavior of the recipient. For a long time it was thought that the remarkable regenerative and functional potential of CNS tissue grafts that had been demonstrated in cold-blooded vertebrates reflected a fundamental difference in the regenerative properties of central nervous tissue between cold-blooded vertebrates and mammals. During the last few years it has become evident however, that at least certain types of intracerebral neural grafts can perfoum just as well in developing and mammals as in developing or adult submammalian vertebrates.

Age-dependent neurobehavioral responses by young and mature adult rats to systemic kainic acid

1996 ◽  
Vol 10 (2) ◽  
pp. 103-108
Author(s):  
Cesario V. Borlongan ◽  
Kimberly B. Bjugstad ◽  
Christine E. Stahl ◽  
Shajmil D. Ross ◽  
Gary W. Arendash ◽  
...  
Keyword(s):  
Kainic Acid ◽  
Adult Rats ◽  
Mature Adult ◽  
Age Dependent

scholarly journals Lung deposition patterns of MWCNT vary with degree of carboxylation

2019 ◽  
Vol 13 (2) ◽  
pp. 143-159
Author(s):  
Andrij Holian ◽  
Raymond F. Hamilton ◽  
Zhequion Wu ◽  
Sanghamitra Deb ◽  
Kevin L. Trout ◽  
...  
Keyword(s):  
Lung Deposition ◽  
Deposition Patterns

scholarly journals Age-Dependent Regulation of Lipogenesis in Human and Rat Adipocytes

2004 ◽  
Vol 89 (9) ◽  
pp. 4601-4606 ◽  
Author(s):  
Ashraf F. Kamel ◽  
Svante Norgren ◽  
Karin Strigård ◽  
Anders Thörne ◽  
Hossein Fakhrai-Rad ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Glucose Transport ◽  
Glucose Transporter ◽  
Age Groups ◽  
Tissue Growth ◽  
Adult Rats ◽  
Male Adult ◽  
Rat Adipocytes ◽  
Transporter Protein ◽  
Age Dependent

The regulation of adipocyte metabolism is of importance for adipose tissue growth and therefore also for the development of obesity. This study was designed to investigate the regulation of basal and insulin-induced lipogenesis, glucose transport, and glucose transporter protein expression in human and rat adipocytes from different age groups. The study included 21 infants, 21 children, nine adults, and 80 male weaned and 20 male adult Fischer rats. The lipogenesis experiments were performed under conditions at which glucose transport is rate limiting. Basal lipogenesis was approximately three times higher in infants and children than in adults, whereas insulin-induced lipogenesis was two times higher in infants than in children and adults. In rats, basal lipogenesis, insulin-induced lipogenesis, and insulin sensitivity were two times higher in weaned than in adult animals. Moreover, basal and insulin-induced glucose transport were two times higher in weaned than in adult rats. No differences were detected in GLUT1 or GLUT4 content between any of the age groups in human or in rat adipocytes. In conclusion, basal and insulin-stimulated lipogenesis are increased in adipocytes early in life. This may promote adipose tissue growth in early age. The data indicate that age-dependent variation in basal and insulin-stimulated lipogenesis is differently regulated.

Sex- and age-dependent effects of early postnatal sibling deprivation on spatial learning and memory in adult rats

2008 ◽  
Vol 186 (1) ◽  
pp. 138-142 ◽  
Author(s):  
Yan-Qin Li ◽  
Xiao-yi Wang ◽  
Hai-feng Zhai ◽  
Xiang Yang Zhang ◽  
Therese Kosten ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Spatial Learning And Memory ◽  
Adult Rats ◽  
Age Dependent
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