scholarly journals Neutrophil–Particle Interactions in Blood Circulation Drive Particle Clearance and Alter Neutrophil Responses in Acute Inflammation

ACS Nano ◽  
2017 ◽  
Vol 11 (11) ◽  
pp. 10797-10807 ◽  
Author(s):  
Catherine A. Fromen ◽  
William J. Kelley ◽  
Margaret B. Fish ◽  
Reheman Adili ◽  
Jeffery Noble ◽  
...  
Keyword(s):  
Blood Circulation ◽  
Acute Inflammation ◽  
Particle Interactions ◽  
Particle Clearance

scholarly journals URINARY RETENTION EFFECT IN THE INCREASED OF PSA EXPRESSION WITHIN PROSTATIC TISSUE

2015 ◽  
Vol 22 (2) ◽  
Author(s):  
Wahjoe Djatisoesanto ◽  
Doddy M Soebadi ◽  
I Ketut Sudiana
Keyword(s):  
Urinary Retention ◽  
Blood Circulation ◽  
Acute Inflammation ◽  
Study Data ◽  
Prostatic Tissue ◽  
Control Group ◽  
Systemic Blood ◽  
Study Results ◽  
Level Of Significance ◽  
Prostatic Gland

Objective: To determine whether the increased of PSA expression within prostatic tissue and subsequent systemic blood circulation in acute urinary retention cases of nonmalignant origin were caused by acute inflammation on the prostatic gland. Following this inflammation, PSA willincrease, producing byacinar epitelial cells in the gland and continue to capillary vessels before entering the blood circulation. Material & method: Thirty male Rattus Norvegicus were randomly allocated into 3 groups. A control group underwent urethral manipulation, treatment-1 group and -2 group underwent proximal urethral ligation. Prostatectomy was performed after 24 hours in the control and treatment-1 group. Ligation was removed after 24 hours in treatment-2 group, and prostatectomy performed after 4x24 hours. Each prostate specimen was examined for PSA expression by immunohistochemistry methods in the prostatic gland. Statistical analysis of study data was analyzed by descriptive statistics and performed ANOVA with level of significance α = 0.01.Results: Study results showed an increase PSA expression significantly after urinary retention and returned to normal values four days later after relief of retention.Conclusion: Urinary retention caused acute inflammation on the prostatic gland and increased PSA expression within prostatic tissue. Entry of PSA into stroma and subsequent systemic blood circulation occur through significant increase in PSA production by acinar epithelial cells.

Subserous appendectomy as a method of prevention of postoperative complications

1982 ◽  
Vol 63 (3) ◽  
pp. 35-37
Author(s):  
I. P. Shatilov
Keyword(s):  
Postoperative Complications ◽  
Blood Circulation ◽  
Acute Inflammation

On the basis of 340 operations for destructive forms of appendicitis, it was shown that subserous appendectomy as a plastic method of peritonization of the stump of the appendix in acute inflammation reliably seals and peritonizes the stump, without disturbing blood circulation in the wall of the cecum, which creates favorable opportunities for eliminating residual inflammation in the cecum.

scholarly journals A specific role of integrin Mac-1 in accelerated macrophage efflux to the lymphatics

Blood ◽  
2005 ◽  
Vol 106 (9) ◽  
pp. 3234-3241 ◽  
Author(s):  
Chunzhang Cao ◽  
Daniel A. Lawrence ◽  
Dudley K. Strickland ◽  
Li Zhang
Keyword(s):  
Lymph Nodes ◽  
Blood Circulation ◽  
Cell Activation ◽  
Acute Inflammation ◽  
Blood Monocytes ◽  
Genetic Inactivation ◽  
Inflammatory Site ◽  
Peritoneal Mesothelium ◽  
Inflammatory Macrophages

Abstract In response to injury, monocytes migrate to the site of inflammation, where they differentiate into macrophages and participate in various biologic processes. However, their fate during the resolution of acute inflammation is not fully understood. Here, we show that inflammatory macrophages do not die locally by apoptosis; rather, they migrate across the peritoneal mesothelium to the lymphatics, through which they further migrate to the lymph nodes and to the blood circulation. Macrophage efflux is enhanced considerably on cell activation, and such accelerated macrophage migration is dependent specifically on integrin Mac-1, and can be blocked by addition of its antagonist. Thus, genetic inactivation of Mac-1 in mice inhibits the accelerated macrophage efflux from the inflammatory site to the lymphatics, but it does not compromise the accumulation of blood monocytes into the inflammatory site. Together, our study demonstrates that Mac-1 is involved specifically in the efflux of activated macrophages to the lymphatics, suggesting that Mac-1 may play an important role in the removal of local inflammatory macrophages and in their subsequent migration to the lymph nodes, a process that is critical to the development of the adaptive immunity.

scholarly journals Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration

2018 ◽  
Vol 115 (7) ◽  
pp. E1550-E1559 ◽  
Author(s):  
Nathalie Cloutier ◽  
Isabelle Allaeys ◽  
Genevieve Marcoux ◽  
Kellie R. Machlus ◽  
Benoit Mailhot ◽  
...  
Keyword(s):  
Platelet Count ◽  
Blood Circulation ◽  
Acute Inflammation ◽  
Antibody Responses ◽  
Fcγ Receptor ◽  
Dense Granules ◽  
Activated Platelets ◽  
Clinical Conditions ◽  
Wall Injury ◽  
Platelet Functions

There is a growing appreciation for the contribution of platelets to immunity; however, our knowledge mostly relies on platelet functions associated with vascular injury and the prevention of bleeding. Circulating immune complexes (ICs) contribute to both chronic and acute inflammation in a multitude of clinical conditions. Herein, we scrutinized platelet responses to systemic ICs in the absence of tissue and endothelial wall injury. Platelet activation by circulating ICs through a mechanism requiring expression of platelet Fcγ receptor IIA resulted in the induction of systemic shock. IC-driven shock was dependent on release of serotonin from platelet-dense granules secondary to platelet outside-in signaling by αIIbβ3 and its ligand fibrinogen. While activated platelets sequestered in the lungs and leaky vasculature of the blood–brain barrier, platelets also sequestered in the absence of shock in mice lacking peripheral serotonin. Unexpectedly, platelets returned to the blood circulation with emptied granules and were thereby ineffective at promoting subsequent systemic shock, although they still underwent sequestration. We propose that in response to circulating ICs, platelets are a crucial mediator of the inflammatory response highly relevant to sepsis, viremia, and anaphylaxis. In addition, platelets recirculate after degranulation and sequestration, demonstrating that in adaptive immunity implicating antibody responses, activated platelets are longer lived than anticipated and may explain platelet count fluctuations in IC-driven diseases.

Acute Inflammation of the Pancreas

1958 ◽  
Vol 34 (3) ◽  
pp. 467-475 ◽  
Author(s):  
H.L. Bockus
Keyword(s):  
Acute Inflammation

Reduction of paw edema and liver oxidative stress in carrageenan-induced acute inflammation by Lobaria pulmonaria and Parmelia caperata, lichen species, in mice

2019 ◽  
pp. 1-9
Author(s):  
Samira Salem ◽  
Essaid Leghouchi ◽  
Rachid Soulimani ◽  
Jaouad Bouayed
Keyword(s):  
Time Course ◽  
Acute Inflammation ◽  
Lichen Species ◽  
Paw Edema ◽  
Sod Activity ◽  
Edema Formation ◽  
Lobaria Pulmonaria ◽  
Anti Inflammatory ◽  
Endogenous Antioxidant ◽  
Inflammatory Effect

Abstract. Paw edema volume reduction is a useful marker in determining the anti-inflammatory effect of drugs and plant extracts in carrageenan-induced acute inflammation. In this study, the anti-inflammatory effect of Lobaria pulmonaria (LP) and Parmelia caperata (PC), two lichen species, was examined in carrageenan-induced mouse paw edema test. Compared to the controls in carrageenan-induced inflammation (n = 5/group), our results showed that pretreatment by single oral doses with PC extract (50–500 mg/kg) gives better results than LP extract (50–500 mg/kg) in terms of anti-edematous activity, as after 4 h of carrageenan subplantar injection, paw edema formation was inhibited at 82–99% by PC while at 35–49% by LP. The higher anti-inflammatory effect of PC, at all doses, was also observed on the time-course of carrageenan-induced paw edema, displaying profile closely similar to that obtained with diclofenac (25 mg/kg), an anti-inflammatory drug reference (all p < 0.001). Both LP and PC, at all doses, significantly ameliorated liver catalase (CAT) activity (all p < 0.05). However, superoxide dismutase (SOD) activity, glutathione peroxidase (GPx) activity and glutathione (GSH) levels were found increased in liver of PC- compared to LP-carrageenan-injected mice. Our findings demonstrated on one hand higher preventive effects of PC compared to LP in a mouse carrageenan-induced inflammatory model and suggested, on the other hand, that anti-inflammatory effects elicited by the two lichens were closely associated with the amelioration in the endogenous antioxidant status of liver.

Schistosomal Appendicitis in Pregnancy

Swiss Surgery ◽  
2002 ◽  
Vol 8 (3) ◽  
pp. 121-122 ◽  
Author(s):  
Halkic ◽  
Abdelmoumene ◽  
Gintzburger ◽  
Mosimann
Keyword(s):  
Acute Appendicitis ◽  
Schistosoma Haematobium ◽  
Acute Inflammation ◽  
The Body ◽  
Parasitic Infections ◽  
Common Complication ◽  
Surgical Infection ◽  
High Prevalence ◽  
Potential Challenge ◽  
In Pregnancy

Acute appendicitis is the most common acute surgical infection during pregnancy. Although usually pyogenic in origin, parasitic infections account for a small percentage of cases. Despite the relatively high prevalence of acute appendicitis in our environment, it is not commonly associated with schistosomiasis. We report here the association of pregnancy and appendicitis caused by Schistosoma haematobium. Schistosomiasis is very common complication of pregnancy in hyperendemic areas. Schistosome egg masses can lodge throughout the body and cause acute inflammation of the appendix, liver and spleen. Congestion of pelvic vessels during pregnancy facilitates passage of eggs into the villi and intervillous spaces, causing an inflammatory reaction. Tourism and immigration make this disease a potential challenge for practitioners everywhere.

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