Magnetic Nanoliposomes as in Situ Microbubble Bombers for Multimodality Image-Guided Cancer Theranostics

ACS Nano ◽  
2017 ◽  
Vol 11 (2) ◽  
pp. 1509-1519 ◽  
Author(s):  
Yang Liu ◽  
Fang Yang ◽  
Chuxiao Yuan ◽  
Mingxi Li ◽  
Tuantuan Wang ◽  
...  
Keyword(s):  
Image Guided ◽  
Multimodality Image ◽  
Cancer Theranostics

scholarly journals Photoactivatable dihydroalkaloids for cancer theranostics with AIE characteristics

2020 ◽  
Author(s):  
Xia Ling ◽  
Letao Huang ◽  
Youzhen Li ◽  
Qing Wan ◽  
Zhiming Wang ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Cancer Cells ◽  
Treatment Efficacy ◽  
Therapeutic Dose ◽  
Dehydrogenation Reaction ◽  
Precise Control ◽  
Image Guided ◽  
New Strategy ◽  
Cancer Theranostics

Chemotherapeutics with systemic administration usually suffer from low treatment efficacy and off-target toxicity. In contrary, the photoactivatable cancer theranostics can achieve image-guided precise control of therapeutic dose and location. However, the conventional photoactivatable chemotherapeutics usually require decoration of chemotherapeutics with additional photo-responsive groups through tedious synthetic procedures, which can lead to undesirable toxic byproducts and seriously restrict their applications. Herein, we propose a new strategy for photoactivatable caner theranostics based on photooxidative dehydrogenation reaction, which is only associating with water as the byproduct. To demonstrate the power of this strategy, we utilized the natural dihydrobenzo[c]phenanthridine alkaloids of DHCHE and DHSAN as photoactivatable theranostics to achieve selective imaging and killing of cancer cells by in situ transformation into nucleus-targeted CHE and SAN under light irradiation. Notably, CHE is featured with aggregation-induced emission (AIE) characteristics, which can be used for precise control of the photoactivatable therapeutic dose. This photoactivatable strategy based on dihydroalkaloids is thus promising for precise cancer treatment in clinic.<br>

scholarly journals Photoactivatable dihydroalkaloids for cancer theranostics with AIE characteristics

2020 ◽  
Author(s):  
Xia Ling ◽  
Letao Huang ◽  
Youzhen Li ◽  
Qing Wan ◽  
Zhiming Wang ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Cancer Cells ◽  
Treatment Efficacy ◽  
Therapeutic Dose ◽  
Dehydrogenation Reaction ◽  
Precise Control ◽  
Image Guided ◽  
New Strategy ◽  
Cancer Theranostics

Chemotherapeutics with systemic administration usually suffer from low treatment efficacy and off-target toxicity. In contrary, the photoactivatable cancer theranostics can achieve image-guided precise control of therapeutic dose and location. However, the conventional photoactivatable chemotherapeutics usually require decoration of chemotherapeutics with additional photo-responsive groups through tedious synthetic procedures, which can lead to undesirable toxic byproducts and seriously restrict their applications. Herein, we propose a new strategy for photoactivatable caner theranostics based on photooxidative dehydrogenation reaction, which is only associating with water as the byproduct. To demonstrate the power of this strategy, we utilized the natural dihydrobenzo[c]phenanthridine alkaloids of DHCHE and DHSAN as photoactivatable theranostics to achieve selective imaging and killing of cancer cells by in situ transformation into nucleus-targeted CHE and SAN under light irradiation. Notably, CHE is featured with aggregation-induced emission (AIE) characteristics, which can be used for precise control of the photoactivatable therapeutic dose. This photoactivatable strategy based on dihydroalkaloids is thus promising for precise cancer treatment in clinic.<br>

scholarly journals Recurrent Chordoma Resection in the Advanced Multimodality Image Guided Operating Suite: 2-Dimensional Operative Video

2021 ◽  
Vol 20 (5) ◽  
pp. E344-E345
Author(s):  
Walid Ibn Essayed ◽  
Kaith K Almefty ◽  
Ossama Al-Mefty
Keyword(s):  
Skull Base ◽  
Surgical Resection ◽  
Petrous Apex ◽  
Tumor Control ◽  
Image Guided ◽  
Endoscopy Ultrasound ◽  
Radiation Induced ◽  
Multimodality Image ◽  
The Right ◽  
Operating Suite

Abstract Recurrent skull base chordomas are challenging lesions. They already had maximum radiation, and in the absence of any effective medical treatment, surgical resection is the only treatment.1,2 Surgery on recurrent previously radiated chordomas, however, carries much higher risk and the likelihood of subtotal resection. Maximizing tumor resection allows longer tumor control.3-5 The Advanced Multimodality Image Guided Operating Suite developed at the Brigham and Women's Hospital, Harvard Medical School, with the support of the National Institutes of Health, provides an optimal environment to manage these tumors. It offers the capability to obtain and integrate multiple modalities during surgery, including magnetic resonance imaging (MRI), positron emission tomography-computed tomography (PET-CT), endoscopy, ultrasound, fluoroscopy, and the ability to perform emergent endovascular procedures.5-7 The patient is a 39-yr-old male, presenting after 19 yr follow-up of a surgical resection and proton beam treatment for a skull base chordoma. He developed progressive ophthalmoplegia due to recurrence of his chordoma at the right petrous apex and cavernous sinus. Preoperative angiography demonstrated narrowing of the petrous segment of the right carotid artery suspect of radiation-induced angiopathy. The presence of radiation-induced angiopathy increases the risk of intraoperative carotid rupture, and the availability of endovascular intervention in the operative suite added favorable preparedness to deal with such complications if they happen. Given the clinical and radiological progression, surgical intervention was carried out through the prior zygomatic approach with the goal of performing maximum resection.8 The patient had an uneventful postoperative course and remained stable until he had a second recurrence 4 yr later. The patient consented to the procedure.

scholarly journals Image-guided Raman spectroscopic recovery of canine cortical bone contrast in situ

2008 ◽  
Vol 16 (16) ◽  
pp. 12190 ◽  
Author(s):  
Subhadra Srinivasan ◽  
Matthew Schulmerich ◽  
Jacqueline H. Cole ◽  
Kathryn A. Dooley ◽  
Jaclynn M. Kreider ◽  
...  
Keyword(s):  
Cortical Bone ◽  
Raman Spectroscopic ◽  
Image Guided

scholarly journals Multimodality Image-Guided Cryoablation for Inoperable Tumor-Induced Osteomalacia

2017 ◽  
Vol 32 (11) ◽  
pp. 2248-2256 ◽  
Author(s):  
Sri Harsha Tella ◽  
Hayet Amalou ◽  
Bradford J Wood ◽  
Richard Chang ◽  
Clara C Chen ◽  
...  
Keyword(s):  
Image Guided ◽  
Multimodality Image

scholarly journals Integrating Nanotherapeutic Platforms to Image Guided Approaches for Management of Cancer

2020 ◽  
Author(s):  
Asad Ali ◽  
Zeeshan Ahmad ◽  
Usama Ahmad ◽  
Mohd Muazzam Khan ◽  
Md. Faheem Haider ◽  
...  
Keyword(s):  
Polymeric Nanoparticles ◽  
Treatment Plan ◽  
Diagnostic Testing ◽  
Cancer Therapeutics ◽  
Image Guided ◽  
Comprehensive Diagnosis ◽  
Gold Nanomaterials ◽  
Cancer Theranostics ◽  
Targeted Approach ◽  
Molecular Images

Cancer is a leading cause of mortality worldwide, accounting for 8.8 million deaths in 2015. The landscape of cancer therapeutics is rapidly advancing with development of new and sophisticated approaches to diagnostic testing. Treatment plan for early diagnosed patients include radiation therapy, tumor ablation, surgery, immunotherapy and chemotherapy. However the treatment can only be initiated when the cancer has been diagnosed thoroughly. Theranostics is a term that combines diagnostics with therapeutics. It embraces multiple techniques to arrive at comprehensive diagnosis, molecular images and an individualized treatment regimen. Recently, there is an effort to tangle the emerging approach with nanotechnologies, in an attempt to develop theranostic nanoplatforms and methodologies. Theranostic approach to management of cancer offers numerous advantages. They are designed to monitor cancer treatment in real time. A wide variety of theranostic nanoplatforms that are based on diverse nanostructures like magnetic nanoparticles, carbon nanotubes, gold nanomaterials, polymeric nanoparticles and silica nanoparticles showed great potential as cancer theranostics. Nano therapeutic platforms have been successful in integrating image guidance with targeted approach to treat cancer.

scholarly journals Spine Cryoablation: A Multimodality Image-Guided Approach for Tumors Adjacent to Major Neural Elements

2016 ◽  
Vol 37 (12) ◽  
pp. 2396-2399 ◽  
Author(s):  
J.P. Guenette ◽  
K. Tuncali ◽  
N. Himes ◽  
S. Tatli ◽  
T.C. Lee
Keyword(s):  
Image Guided ◽  
Multimodality Image
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