Substrate Partitioning into Protein Macromolecular Frameworks for Enhanced Catalytic Turnover

ACS Nano ◽  
2021 ◽  
Author(s):  
Ekaterina Selivanovitch ◽  
Masaki Uchida ◽  
Byeongdu Lee ◽  
Trevor Douglas
Keyword(s):  
Substrate Partitioning

Dietary Composition Influences Short-term Endurance Training–Induced Adaptations of Substrate Partitioning during Exercise

2004 ◽  
Vol 14 (1) ◽  
pp. 38-61 ◽  
Author(s):  
Kevin A. Jacobs ◽  
David R. Paul ◽  
Ray J. Geor ◽  
Kenneth W. Hinchcliff ◽  
W. Michael Sherman
Keyword(s):  
Endurance Training ◽  
Time Trial ◽  
Whole Body ◽  
High Fat ◽  
Short Term ◽  
Time Trial Performance ◽  
Glucose Flux ◽  
Before And After ◽  
Substrate Partitioning ◽  
Trial Performance

The purpose of the current study was to examine the influence of dietary composition on short-term endurance training–induced adaptations of substrate partitioning and time trial exercise performance. Eight untrained males cycled for 90 min at ~54% aerobic capacity while being infused with [6,62H]glucose before and after two 10-d experimental phases separated by a 2-week washout period. Time trial performance was measured after the 90-min exercise trials before and after the 2nd experimental phase. During the first 10-d phase, subjects were randomly assigned to consume either a high carbohydrate or high fat diet while remaining inactive (CHO or FAT). During the second 10-d phase, subjects consumed the opposite diet, and both groups performed identical daily supervised endurance training (CHO+T or FAT+T). CHO and CHO+T did not affect exercise metabolism. FAT reduced glucose flux at the end of exercise, while FAT+T substantially increased whole body lipid oxidation during exercise and reduced glucose flux at the end of exercise. Despite these differences in adaptation of substrate use, training resulted in similar improvements in time trial performance for both groups. We conclude that (a) 10-d high fat diets result in substantial increases in whole body lipid oxidation during exercise when combined with daily aerobic training, and (b) diet does not affect short-term training-induced improvements in high-intensity time trial performance.

scholarly journals Effect of mirtazapine on metabolism and energy substrate partitioning in healthy men

JCI Insight ◽  
2019 ◽  
Vol 4 (1) ◽  
Author(s):  
Johannes M. Hennings ◽  
Sarah Heel ◽  
Katharina Lechner ◽  
Manfred Uhr ◽  
Tatjana Dose ◽  
...  
Keyword(s):  
Energy Substrate ◽  
Healthy Men ◽  
Substrate Partitioning
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