scholarly journals Self-Assembling Peptide Dendron Nanoparticles with High Stability and a Multimodal Antimicrobial Mechanism of Action

ACS Nano ◽  
2021 ◽  
Author(s):  
Zhenheng Lai ◽  
Qiao Jian ◽  
Guoyu Li ◽  
Changxuan Shao ◽  
Yongjie Zhu ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
High Stability ◽  
Self Assembling ◽  
Antimicrobial Mechanism

scholarly journals A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability

2017 ◽  
Vol 32 (1) ◽  
pp. 240-247 ◽  
Author(s):  
Chiara Fulci ◽  
Dante Rotili ◽  
Anastasia De Luca ◽  
Lorenzo Stella ◽  
Blasco Morozzo della Rocca ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
High Stability

scholarly journals Real-Time Characterization of an Antimicrobial Mechanism-of-Action with Nonlinear Optical Scattering

2017 ◽  
Vol 112 (3) ◽  
pp. 382a
Author(s):  
Michael J. Wilhelm ◽  
Bruk Mensa ◽  
Mohammad Sharifian Gh. ◽  
William F. DeGrado ◽  
Hai-Lung Dai
Keyword(s):  
Real Time ◽  
Mechanism Of Action ◽  
Nonlinear Optical ◽  
Optical Scattering ◽  
Antimicrobial Mechanism

Protein post-translational modification in host defense: the antimicrobial mechanism of action of human eosinophil cationic protein native forms

FEBS Journal ◽  
2014 ◽  
Vol 281 (24) ◽  
pp. 5432-5446 ◽  
Author(s):  
Vivian A. Salazar ◽  
Jenny Rubin ◽  
Mohammed Moussaoui ◽  
David Pulido ◽  
Maria Victòria Nogués ◽  
...  
Keyword(s):  
Host Defense ◽  
Mechanism Of Action ◽  
Eosinophil Cationic Protein ◽  
Post Translational Modification ◽  
Cationic Protein ◽  
Human Eosinophil ◽  
Antimicrobial Mechanism

scholarly journals Ultrasound processing of liquid system(s) and its antimicrobial mechanism of action

2017 ◽  
Vol 65 (4) ◽  
pp. 313-318 ◽  
Author(s):  
D. Spiteri ◽  
C. Chot-Plassot ◽  
J. Sclear ◽  
K.A. Karatzas ◽  
C. Scerri ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Liquid System ◽  
Antimicrobial Mechanism

scholarly journals Fabrication of Polymer Micelles with Zwitterionic Shell and Biodegradable Core for Reductively Responsive Release of Doxorubicin

Polymers ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1019 ◽  
Author(s):  
Junting Jiang ◽  
Junbo Li ◽  
Biyu Zhou ◽  
Chaohuang Niu ◽  
Wendi Wang ◽  
...  
Keyword(s):  
Drug Release ◽  
Disulfide Bonds ◽  
High Stability ◽  
Polymeric Micelles ◽  
Raft Polymerization ◽  
Drug Efficacy ◽  
Low Protein ◽  
Self Assembling ◽  
Group Modification ◽  
End Group Modification

To achieve a high stability in physiological environment and rapid intracellular drug release, a biodegradable zwitterionic triblock copolymer with a disulfide-linked poly-ε-caprolactone and polycarboxybetaine methacrylate (PCBMA-SS-PCL-SS-PCBMA) was prepared for micellar carrier to delivery doxorubicin (DOX) into tumor cells. PCBMA-SS-PCL-SS-PCBMA was obtained by following steps: i) introducing disulfide bonds through end-group modification of PCL diol with cystamine dihydrochloride; ii) preparing PCL-RAFT macromolecular chain transfer agent by EDC/NHS chemistry; iii) RAFT polymerization of zwitterionic monomer. Self-assembling from PCBMA-SS-PCL-SS-PCBMA, polymeric micelles had many advantages, such as ultra-low protein absorption in serum and obvious reduction-responsiveness in the presence of DTT. Furthermore, DOX-loaded micelles exhibited high stability upon centrifugation and lyophilization, a fast intracellular drug release and enhanced drug efficacy due to GSH-triggered PCBMA shell shedding and micellar reassembling. Thus, the polymeric micelles integrated several functions and properties could be prospectively utilized as valuable nanocarriers in cancer chemotherapeutics.

scholarly journals Classification of antimicrobial mechanism of action using bacterial time-lapse imaging

2021 ◽  
Author(s):  
Xudong Ouyang ◽  
Jelmer Hoeksma ◽  
Tjalling K. Siersma ◽  
Leendert W. Hamoen ◽  
Jeroen den Hertog
Keyword(s):  
Mechanism Of Action ◽  
Morphological Changes ◽  
Time Lapse ◽  
Basic Knowledge ◽  
Imaging Method ◽  
Fungal Culture ◽  
Bacterial Cells ◽  
Simple Method ◽  
Antimicrobial Mechanism

AbstractAntimicrobial resistance is a major threat to human health. Basic knowledge of antimicrobial mechanism of action (MoA) is imperative for patient care and for identification of novel antimicrobials. However, the process of antimicrobial MoA identification is relatively laborious. Here, we developed a simple, quantitative time-lapse fluorescence imaging method, Dynamic Bacterial Morphology Imaging (DBMI), to facilitate this process. It uses a membrane dye and a nucleoid dye to track the morphological changes of single Bacillus subtilis cells in response to antimicrobials for up to 60 min. DBMI of bacterial cells facilitated assignment of the MoAs of 14 distinct, known antimicrobial compounds to the five main classes. Using this method, we found that the poorly studied antimicrobial, harzianic acid, a secondary metabolite that we purified from the fungal culture of Oidiodendron flavum, targets the cell envelope. We conclude that DBMI is a simple method, which facilitates rapid classification of the MoA of antimicrobials in functionally distinct classes.

Self-assembling RuO2 nanogranulates with few carbon layers as an interconnected nanoporous structure for lithium–oxygen batteries

2020 ◽  
Vol 56 (53) ◽  
pp. 7253-7256
Author(s):  
Wei-Hong Lai ◽  
Zhi Zheng ◽  
Wanlin Wang ◽  
Lei Wang ◽  
Yao-Jie Lei ◽  
...  
Keyword(s):  
High Performance ◽  
High Stability ◽  
Nanoporous Structure ◽  
Self Assembling ◽  
Lithium Oxygen Batteries

Interconnected nanoporous RuO2 nanogranulates coated with a few layers of carbon enable high-performance Li–O2 batteries with high stability.

Fluorescence anisotropy analysis of the mechanism of action of mesenterocin 52A: speculations on antimicrobial mechanism

2008 ◽  
Vol 81 (2) ◽  
pp. 339-347 ◽  
Author(s):  
Jordane Jasniewski ◽  
Catherine Cailliez-Grimal ◽  
Mohamed Younsi ◽  
Jean-Bernard Millière ◽  
Anne-Marie Revol-Junelles
Keyword(s):  
Mechanism Of Action ◽  
Fluorescence Anisotropy ◽  
Antimicrobial Mechanism

Pyrrolomycins as antimicrobial agents. Microwave-assisted organic synthesis and insights into their antimicrobial mechanism of action

2019 ◽  
Vol 27 (5) ◽  
pp. 721-728 ◽  
Author(s):  
Maria Valeria Raimondi ◽  
Roberta Listro ◽  
Maria Grazia Cusimano ◽  
Mery La Franca ◽  
Teresa Faddetta ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Mechanism Of Action ◽  
Antimicrobial Agents ◽  
Microwave Assisted ◽  
Antimicrobial Mechanism
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