Reactive Oxygen Species Responsive Theranostic Nanoplatform for Two-Photon Aggregation-Induced Emission Imaging and Therapy of Acute and Chronic Inflammation

ACS Nano ◽  
2020 ◽  
Vol 14 (5) ◽  
pp. 5862-5873 ◽  
Author(s):  
Boxuan Ma ◽  
Hong Xu ◽  
Weihua Zhuang ◽  
Yanan Wang ◽  
Gaocan Li ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Chronic Inflammation ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Aggregation Induced Emission ◽  
Two Photon ◽  
Acute And Chronic Inflammation

Superoxide, peroxynitrite and oxidative/nitrative stress in inflammation

2006 ◽  
Vol 34 (5) ◽  
pp. 965-970 ◽  
Author(s):  
D. Salvemini ◽  
T.M. Doyle ◽  
S. Cuzzocrea
Keyword(s):  
Reactive Oxygen Species ◽  
Chronic Inflammation ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Comprehensive Review ◽  
Limited Space ◽  
Review Articles ◽  
Nitrative Stress ◽  
Acute And Chronic Inflammation ◽  
Considerable Body

A considerable body of evidence suggests that formation of potent reactive oxygen species and resulting oxidative/nitrative stress play a major role in acute and chronic inflammation and pain. Much of the knowledge in this field has been gathered by the use of pharmacological and genetic approaches. In this mini review, we will evaluate recent advances made towards understanding the roles of reactive oxygen species in inflammation, focusing in particular on superoxide and peroxynitrite. Given the limited space to cover this broad topic, here we will refer the reader to comprehensive review articles whenever possible.

scholarly journals Novel Antioxidant Properties of Doxycycline

2018 ◽  
Vol 19 (12) ◽  
pp. 4078 ◽  
Author(s):  
Dahn Clemens ◽  
Michael Duryee ◽  
Cleofes Sarmiento ◽  
Andrew Chiou ◽  
Jacob McGowan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Hydrogen Peroxide ◽  
Chronic Inflammation ◽  
Antioxidant Properties ◽  
Antibacterial Properties ◽  
Reactive Oxygen ◽  
Protein Adducts ◽  
Oxygen Species ◽  
Free System

Doxycycline (DOX), a derivative of tetracycline, is a broad-spectrum antibiotic that exhibits a number of therapeutic activities in addition to its antibacterial properties. For example, DOX has been used in the management of a number of diseases characterized by chronic inflammation. One potential mechanism by which DOX inhibits the progression of these diseases is by reducing oxidative stress, thereby inhibiting subsequent lipid peroxidation and inflammatory responses. Herein, we tested the hypothesis that DOX directly scavenges reactive oxygen species (ROS) and inhibits the formation of redox-mediated malondialdehyde-acetaldehyde (MAA) protein adducts. Using a cell-free system, we demonstrated that DOX scavenged reactive oxygen species (ROS) produced during the formation of MAA-adducts and inhibits the formation of MAA-protein adducts. To determine whether DOX scavenges specific ROS, we examined the ability of DOX to directly scavenge superoxide and hydrogen peroxide. Using electron paramagnetic resonance (EPR) spectroscopy, we found that DOX directly scavenged superoxide, but not hydrogen peroxide. Additionally, we found that DOX inhibits MAA-induced activation of Nrf2, a redox-sensitive transcription factor. Together, these findings demonstrate the under-recognized direct antioxidant property of DOX that may help to explain its therapeutic potential in the treatment of conditions characterized by chronic inflammation and increased oxidative stress.

scholarly journals Prospects for More Efficient Multi-Photon Absorption Photosensitizers Exhibiting Both Reactive Oxygen Species Generation and Luminescence

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6323
Author(s):  
Emma Robbins ◽  
Stéphanie Leroy-Lhez ◽  
Nicolas Villandier ◽  
Marek Samoć ◽  
Katarzyna Matczyszyn
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Inorganic Nanoparticles ◽  
Photon Absorption ◽  
Quantum Yields ◽  
Oxygen Species ◽  
Microscopy Imaging ◽  
Two Photon Absorption ◽  
Two Photon

The use of two-photon absorption (TPA) for such applications as microscopy, imaging, and photodynamic therapy (PDT) offers several advantages over the usual one-photon excitation. This creates a need for photosensitizers that exhibit both strong two-photon absorption and the highly efficient generation of reactive oxygen species (ROS), as well as, ideally, bright luminescence. This review focuses on different strategies utilized to improve the TPA properties of various multi-photon absorbing species that have the required photophysical properties. Along with well-known families of photosensitizers, including porphyrins, we also describe other promising organic and organometallic structures and more complex systems involving organic and inorganic nanoparticles. We concentrate on the published studies that provide two-photon absorption cross-section values and the singlet oxygen (or other ROS) and luminescence quantum yields, which are crucial for potential use within PDT and diagnostics. We hope that this review will aid in the design and modification of novel TPA photosensitizers, which can help in exploiting the features of nonlinear absorption processes.

Aggregation-induced emission-active Au nanoclusters for ratiometric sensing and bioimaging of highly reactive oxygen species

2019 ◽  
Vol 55 (100) ◽  
pp. 15097-15100 ◽  
Author(s):  
Xiang Ran ◽  
Zhenzhen Wang ◽  
Fang Pu ◽  
Zhen Liu ◽  
Jinsong Ren ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Au Nanoclusters ◽  
Aggregation Induced Emission ◽  
Ratiometric Sensing

A nanoprobe based on aggregation-induced emission-active Au nanoclusters for ratiometric sensing and bioimaging of highly reactive oxygen species is constructed.

scholarly journals Oxalate-curcumin–based probe for micro- and macroimaging of reactive oxygen species in Alzheimer’s disease

2017 ◽  
Vol 114 (47) ◽  
pp. 12384-12389 ◽  
Author(s):  
Jian Yang ◽  
Xueli Zhang ◽  
Peng Yuan ◽  
Jing Yang ◽  
Yungen Xu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Reactive Oxygen Species ◽  
Alzheimer's Disease ◽  
Reactive Oxygen ◽  
Amyloid Angiopathy ◽  
Oxygen Species ◽  
Two Photon ◽  
Nirf Imaging ◽  
Photon Imaging ◽  
Two Photon Imaging

Alzheimer’s disease (AD) is an irreversible neurodegenerative disorder that has a progression that is closely associated with oxidative stress. It has long been speculated that the reactive oxygen species (ROS) level in AD brains is much higher than that in healthy brains. However, evidence from living beings is scarce. Inspired by the “chemistry of glow stick,” we designed a near-IR fluorescence (NIRF) imaging probe, termed CRANAD-61, for sensing ROS to provide evidence at micro- and macrolevels. In CRANAD-61, an oxalate moiety was utilized to react with ROS and to consequentially produce wavelength shifting. Our in vitro data showed that CRANAD-61 was highly sensitive and rapidly responsive to various ROS. On reacting with ROS, its excitation and emission wavelengths significantly shifted to short wavelengths, and this shifting could be harnessed for dual-color two-photon imaging and transformative NIRF imaging. In this report, we showed that CRANAD-61 could be used to identify “active” amyloid beta (Aβ) plaques and cerebral amyloid angiopathy (CAA) surrounded by high ROS levels with two-photon imaging (microlevel) and to provide relative total ROS concentrations in AD brains via whole-brain NIRF imaging (macrolevel). Lastly, we showed that age-related increases in ROS levels in AD brains could be monitored with our NIRF imaging method. We believe that our imaging with CRANAD-61 could provide evidence of ROS at micro- and macrolevels and could be used for monitoring ROS changes under various AD pathological conditions and during drug treatment.

scholarly journals Reactive oxygen species: rapid fire in inflammation

2017 ◽  
Vol 39 (4) ◽  
pp. 30-33 ◽  
Author(s):  
Sonia Ingram ◽  
Marina Diotallevi
Keyword(s):  
Reactive Oxygen Species ◽  
Inflammatory Response ◽  
Chronic Inflammation ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Crucial Element

Everyone has encountered it at some point: inflammation. That horrible feeling when you've hurt yourself and the skin and tissue around the injury swells, goes red, feels hot and painful. It is even worse if it gets infected, then you really know about it! You can feel sick, weak and feverish as your body tries to fight off the infection and heal itself. Inflammation is really important for keeping us healthy. Sometimes, however, the body's inflammatory response can be a bit overzealous, not shutting down when it's supposed to, which can lead to various problems and even a state of disease. To fully understand and be able to effectively treat these diseases, we need a better understanding of how and why this chronic inflammation occurs. Could a crucial element in our lives, oxygen, be key to furthering our understanding?

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