Design and Solid-Phase Parallel Synthesis of 2,4,5-Trisubstituted Thiazole Derivatives via Cyclization Reaction with a Carbamimidothioate Linker

2019 ◽  
Vol 21 (6) ◽  
pp. 482-488 ◽  
Author(s):  
Hye-Jin Kwon ◽  
Ye-Ji Kim ◽  
Si-Yeon Han ◽  
Young-Dae Gong
Keyword(s):  
Solid Phase ◽  
Parallel Synthesis ◽  
Cyclization Reaction ◽  
Thiazole Derivatives

scholarly journals Fluorous methods for synthesis and separation of organic molecules

2000 ◽  
Vol 72 (9) ◽  
pp. 1649-1653 ◽  
Author(s):  
Dennis P. Curran
Keyword(s):  
Organic Molecules ◽  
Solid Phase ◽  
Liquid Extraction ◽  
Parallel Synthesis ◽  
Solution Phase ◽  
Phase Extraction ◽  
Organic Reaction ◽  
Reverse Phase ◽  
Liquid Liquid Extraction ◽  
Fluorous Tag

Fluorous molecules partition out of an organic phase and into a fluorous (highly fluorinated) phase in a liquid-liquid extraction. New fluorous techniques allow simple yet substantive separations of organic reaction mixtures based on the presence or absence of a fluorous tag. Fluorous-tagged molecules can also be separated from nontagged molecules by solid phase extraction over fluorous reverse-phase silica gel. This technique is ideal for solution-phase parallel synthesis because it allows simple yet substantive separations of organic reaction mixtures.

scholarly journals Formation of New Ligands Imine- (Oxazole, Thiazole, Thiophene) And Study of (Chemical Investigation and Chromatographic Applications)

2018 ◽  
Vol 7 (4.36) ◽  
pp. 580
Author(s):  
Mostafa N. Mohamed Salih ◽  
Zaid Noor ObaidAl-Husseini ◽  
Nagham Mahmood Aljamali
Keyword(s):  
1H Nmr ◽  
Condensation Reaction ◽  
Cyclization Reaction ◽  
Chemical Investigation ◽  
Basic Medium ◽  
Thiazole Derivatives ◽  
Imine Group ◽  
Thiophene Derivatives ◽  
Uv Visible ◽  
Imine Ligands

(Oxazole, Thiazole, Thiophene) derivatives- Imine ligands were synthesized in this paper by using  many  reactions such as cyclization  reaction,  chalcone  reaction  in  basic  medium, condensation  reaction  to format four new ligands included heterocycles represented by oxazole, thiophene, thiazole derivatives with imine group in same compounds. The four ligands have been identified by several methods such as spectra of (UV-Visible investigation, 1H NMR, FT.IR) and study of chromatographic applications for all ligands. 

scholarly journals A Traceless Approach for the Solid-Phase Parallel Synthesis of Trisubstituted Oxindoles

2008 ◽  
Vol 10 (5) ◽  
pp. 752-752 ◽  
Author(s):  
Jinwen Xie ◽  
Jing Sun ◽  
Guolin Zhang ◽  
Richard A. Houghten ◽  
Yongping Yu
Keyword(s):  
Solid Phase ◽  
Parallel Synthesis

scholarly journals Traceless solid-phase α-hydroxytropolone synthesis

MedChemComm ◽  
2016 ◽  
Vol 7 (9) ◽  
pp. 1789-1792 ◽  
Author(s):  
Michael P. D'Erasmo ◽  
Takashi Masaoka ◽  
Jennifer A. Wilson ◽  
Errol M. Hunte ◽  
John A. Beutler ◽  
...  
Keyword(s):  
Ring Opening ◽  
Solid Phase ◽  
Parallel Synthesis ◽  
Oxidopyrylium Cycloaddition

α-Hydroxytropolones are established inhibitors of several therapeutically relevant binuclear metalloenzymes. A solid-phase adaptation to an oxidopyrylium cycloaddition/ring-opening procedure is described that allows for rapid parallel synthesis.

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