scholarly journals A Traceless Approach for the Solid-Phase Parallel Synthesis of Trisubstituted Oxindoles

2008 ◽  
Vol 10 (5) ◽  
pp. 752-752 ◽  
Author(s):  
Jinwen Xie ◽  
Jing Sun ◽  
Guolin Zhang ◽  
Richard A. Houghten ◽  
Yongping Yu
Keyword(s):  
Solid Phase ◽  
Parallel Synthesis

scholarly journals Fluorous methods for synthesis and separation of organic molecules

2000 ◽  
Vol 72 (9) ◽  
pp. 1649-1653 ◽  
Author(s):  
Dennis P. Curran
Keyword(s):  
Organic Molecules ◽  
Solid Phase ◽  
Liquid Extraction ◽  
Parallel Synthesis ◽  
Solution Phase ◽  
Phase Extraction ◽  
Organic Reaction ◽  
Reverse Phase ◽  
Liquid Liquid Extraction ◽  
Fluorous Tag

Fluorous molecules partition out of an organic phase and into a fluorous (highly fluorinated) phase in a liquid-liquid extraction. New fluorous techniques allow simple yet substantive separations of organic reaction mixtures based on the presence or absence of a fluorous tag. Fluorous-tagged molecules can also be separated from nontagged molecules by solid phase extraction over fluorous reverse-phase silica gel. This technique is ideal for solution-phase parallel synthesis because it allows simple yet substantive separations of organic reaction mixtures.

scholarly journals Traceless solid-phase α-hydroxytropolone synthesis

MedChemComm ◽  
2016 ◽  
Vol 7 (9) ◽  
pp. 1789-1792 ◽  
Author(s):  
Michael P. D'Erasmo ◽  
Takashi Masaoka ◽  
Jennifer A. Wilson ◽  
Errol M. Hunte ◽  
John A. Beutler ◽  
...  
Keyword(s):  
Ring Opening ◽  
Solid Phase ◽  
Parallel Synthesis ◽  
Oxidopyrylium Cycloaddition

α-Hydroxytropolones are established inhibitors of several therapeutically relevant binuclear metalloenzymes. A solid-phase adaptation to an oxidopyrylium cycloaddition/ring-opening procedure is described that allows for rapid parallel synthesis.

ChemInform Abstract: Identification of a Series of PPARγ/δ Dual Agonists via Solid-Phase Parallel Synthesis.

ChemInform ◽  
2010 ◽  
Vol 33 (8) ◽  
pp. no-no
Author(s):  
Kevin G. Liu ◽  
Millard H. Lambert ◽  
Lisa M. Leesnitzer ◽  
William Oliver Jr. ◽  
Ronda J. Ott ◽  
...  
Keyword(s):  
Solid Phase ◽  
Parallel Synthesis
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