Microwave-Assisted Regioselective Synthesis of 3-Functionalized Indole Derivatives via Three-Component Domino Reaction

2017 ◽  
Vol 19 (11) ◽  
pp. 708-713 ◽  
Author(s):  
Wei Lin ◽  
Yong-Xiang Zheng ◽  
Zhan Xun ◽  
Zhi-Bin Huang ◽  
Da-Qing Shi
Keyword(s):  
Regioselective Synthesis ◽  
Domino Reaction ◽  
Indole Derivatives ◽  
Microwave Assisted

scholarly journals One-pot, regioselective synthesis of functionalized indole derivatives: a three-component domino reaction of arylamine, arylglyoxal, and 4-hydroxycoumarin or 4-hydroxy-6-methyl-2-pyrone

ARKIVOC ◽  
2020 ◽  
Vol 2020 (6) ◽  
pp. 114-125
Author(s):  
Hossein Mehrabi ◽  
Fatemeh Dastouri ◽  
Sara Asadi ◽  
Farzaneh Alizadeh-Bami ◽  
Reza Ranjbar-Karimi
Keyword(s):  
Regioselective Synthesis ◽  
Domino Reaction ◽  
Indole Derivatives ◽  
One Pot

Microwave-Assisted Synthesis of 3-Substituted Indole Derivatives via Three-Component Domino Reaction

2018 ◽  
Vol 38 (4) ◽  
pp. 855 ◽  
Author(s):  
Wei Lin ◽  
Xiuxiu Hu ◽  
Yazhen Wang ◽  
Shuai Song ◽  
Mengye Zhang ◽  
...  
Keyword(s):  
Domino Reaction ◽  
Microwave Assisted Synthesis ◽  
Indole Derivatives ◽  
Microwave Assisted

Acetic acid mediated regioselective synthesis of 2,4,5-trisubstituted thiazoles by a domino multicomponent reaction

2019 ◽  
Vol 43 (22) ◽  
pp. 8644-8650 ◽  
Author(s):  
Mohit Saroha ◽  
Jitender M. Khurana
Keyword(s):  
Acetic Acid ◽  
Multicomponent Reaction ◽  
Regioselective Synthesis ◽  
Domino Reaction ◽  
Thiazole Derivatives ◽  
Active Methylene

Acetic acid mediated regioselective synthesis of novel 2,4,5-trisubstituted thiazole derivatives has been reported by a domino reaction of thiosemicarbazide and aldehydes/ketones/isatin, to generate thiosemicarbazones (in situ) followed by addition of arylglyoxal and active methylene/activated C–H acids/pyrazole/indole in ethanol at 80 °C.

ChemInform Abstract: A Three-Component Domino Reaction of 2-Tetralone, Hydroxylamine and Acetylene: A One-Pot, Highly Regioselective Synthesis of 4,5-Dihydrobenz[e]indoles.

ChemInform ◽  
2010 ◽  
Vol 41 (28) ◽  
pp. no-no
Author(s):  
Alexander M. Vasil'tsov ◽  
Andrei V. Ivanov ◽  
Al'bina I. Mikhaleva ◽  
Boris A. Trofimov
Keyword(s):  
Regioselective Synthesis ◽  
Domino Reaction ◽  
One Pot

Microwave-Assisted Regioselective Synthesis of trans-1-Arenesulfonyl-2-ethoxycarbonyl-3-phenylazetidines

2010 ◽  
Vol 40 (11) ◽  
pp. 1631-1638 ◽  
Author(s):  
Sarika Malik ◽  
Upender K. Nadir ◽  
Pramod S. Pandey
Keyword(s):  
Regioselective Synthesis ◽  
Microwave Assisted

scholarly journals Microwave-Assisted Synthesis, Molecular Docking Studies and Biological Evaluation of Benzothiazole Containing Novel Indole Derivatives

2021 ◽  
Vol 33 (11) ◽  
pp. 2755-2761
Author(s):  
Shaheen Sultana ◽  
P. Pandian ◽  
B. Rajkamal
Keyword(s):  
Molecular Docking ◽  
Reaction Mechanism ◽  
Anticancer Activity ◽  
Mannich Base ◽  
Docking Studies ◽  
Biological Evaluation ◽  
Indole Derivatives ◽  
Standard Drug ◽  
Molecular Docking Studies ◽  
Microwave Assisted

The synthesis of novel indole derivatives 4a-o using a microwave assisted method via Schiff’s base and Mannich base reaction mechanism was described. Compounds 3a-c were synthesized via reaction of 2-amino benzothiazole with substituted isatin by Schiff base reaction mechanism. Also, indole derivatives 4a-o were synthesized via reaction of compounds 3a-c with substituted benzaldehydes by Mannich base reaction. The biological potentials of the newly synthesized indole derivatives were evaluated for their anthelmintic activity and in vitro anticancer activity by MTT assay. The anticancer activity results suggested that indole derivatives 4c-o have activity against MCF-7 and SKOV3 cells in comparison with doxorubicin as standard drug. Furthermore, the molecular docking studies of these novel derivatives of indole showed good agreement with the biological results when their binding pattern and affinity towards the active site of EGFR was also investigated.

ChemInform Abstract: Regioselective Synthesis of Functionalized [1,8]Naphthyridine Derivatives via Three-Component Domino Reaction under Catalyst-Free Conditions.

ChemInform ◽  
2015 ◽  
Vol 46 (26) ◽  
pp. no-no
Author(s):  
Xian Feng ◽  
Jian-Jun Wang ◽  
Juan-Juan Zhang ◽  
Cheng-Pao Cao ◽  
Zhi-Bin Huang ◽  
...  
Keyword(s):  
Regioselective Synthesis ◽  
Domino Reaction ◽  
Catalyst Free

scholarly journals Microwave-assisted rapid and regioselective synthesis of N-(alkoxycarbonylmethyl) nucleobases in water

2007 ◽  
Vol 18 (5) ◽  
pp. 1061-1067 ◽  
Author(s):  
Guirong Qu ◽  
Zhiguang Zhang ◽  
Haiming Guo ◽  
Mingwei Geng ◽  
Ran Xia
Keyword(s):  
Regioselective Synthesis ◽  
Microwave Assisted
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