G-Quadruplex DNA- and RNA-Specific-Binding Proteins Engineered from the RGG Domain of TLS/FUS

2015 ◽  
Vol 10 (11) ◽  
pp. 2564-2569 ◽  
Author(s):  
Kentaro Takahama ◽  
Arisa Miyawaki ◽  
Takumi Shitara ◽  
Keita Mitsuya ◽  
Masayuki Morikawa ◽  
...  
Keyword(s):  
Binding Proteins ◽  
Specific Binding ◽  
Quadruplex Dna ◽  
Dna And Rna ◽  
G Quadruplex

scholarly journals Identification of Ewing’s sarcoma protein as a G-quadruplex DNA- and RNA-binding protein

FEBS Journal ◽  
2011 ◽  
Vol 278 (6) ◽  
pp. 988-998 ◽  
Author(s):  
Kentaro Takahama ◽  
Katsuhito Kino ◽  
Shigeki Arai ◽  
Riki Kurokawa ◽  
Takanori Oyoshi
Keyword(s):  
Ewing’S Sarcoma ◽  
Rna Binding ◽  
Ewing's Sarcoma ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Quadruplex Dna ◽  
Dna And Rna ◽  
G Quadruplex ◽  
Dna And Rna Binding

scholarly journals Yeast transcription co-activator Sub1 and its human homolog PC4 preferentially bind to G-quadruplex DNA

2015 ◽  
Vol 51 (33) ◽  
pp. 7242-7244 ◽  
Author(s):  
Jun Gao ◽  
Boris L. Zybailov ◽  
Alicia K. Byrd ◽  
Wezley C. Griffin ◽  
Shubeena Chib ◽  
...  
Keyword(s):  
Dna Binding ◽  
Binding Proteins ◽  
Dna Binding Proteins ◽  
Human Homolog ◽  
Dna Metabolism ◽  
Quadruplex Dna ◽  
G4 Dna ◽  
G Quadruplex

DNA binding proteins Sub1 and PC4 preferentially bind to G-quadruplex DNA, providing a new link between DNA metabolism and G4-DNA.

Identification of novel interactors of human telomeric G-quadruplex DNA

2015 ◽  
Vol 51 (14) ◽  
pp. 2964-2967 ◽  
Author(s):  
Bruno Pagano ◽  
Luigi Margarucci ◽  
Pasquale Zizza ◽  
Jussara Amato ◽  
Nunzia Iaccarino ◽  
...  
Keyword(s):  
Binding Proteins ◽  
Dna Structure ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
In Cells

Starting from a chemoproteomic-driven approach, novel human telomeric G-quadruplex binding proteins were identified that directly bind the DNA structure in vitro and colocalize with such structures in cells.

scholarly journals A study on a telo21 G-quadruplex DNA specific binding ligand: enhancing the molecular recognition ability via the amino group interactions

RSC Advances ◽  
2018 ◽  
Vol 8 (36) ◽  
pp. 20222-20227 ◽  
Author(s):  
Dongli Li ◽  
Jin-Qiang Hou ◽  
Wei Long ◽  
Yu-Jing Lu ◽  
Wing-Leung Wong ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Specific Binding ◽  
Amino Group ◽  
Amino Groups ◽  
Group Interactions ◽  
Quadruplex Dna ◽  
Fluorescent Signal ◽  
Hydrogen Bonding Interactions ◽  
G Quadruplex ◽  
Recognition Ability

A significant fluorescent signal enhancement attributed to hydrogen-bonding interactions through the amino groups of a small binding ligand in the G-quartets (binding energy: −6.2 kcal mol−1).

scholarly journals The Dynamic Interplay Between Telomere-Binding Proteins POT1 and TPP1 in G-Quadruplex DNA

2012 ◽  
Vol 102 (3) ◽  
pp. 15a
Author(s):  
Helen Hwang ◽  
Noah Buncher ◽  
Patricia Opresko ◽  
Sua Myong
Keyword(s):  
Binding Proteins ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Dynamic Interplay

scholarly journals Correction: A study on a telo21 G-quadruplex DNA specific binding ligand: enhancing the molecular recognition ability via the amino group interactions

RSC Advances ◽  
2018 ◽  
Vol 8 (41) ◽  
pp. 22931-22931
Author(s):  
Dongli Li ◽  
Jin-Qiang Hou ◽  
Wei Long ◽  
Yu-Jing Lu ◽  
Wing-Leung Wong ◽  
...  
Keyword(s):  
Molecular Recognition ◽  
Specific Binding ◽  
Amino Group ◽  
Group Interactions ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Recognition Ability

Correction for ‘A study on a telo21 G-quadruplex DNA specific binding ligand: enhancing the molecular recognition ability via the amino group interactions’ by Dongli Li et al., RSC Adv., 2018, 8, 20222–20227.

scholarly journals Plasmodium falciparum GBP2 is a telomere-associated protein that binds to G-quadruplex DNA and RNA

2021 ◽  
Author(s):  
James Edwards-Smallbone ◽  
Anders L Jensen ◽  
Lydia E Roberts ◽  
Francis Isidore Garcia Totanes ◽  
Sarah R Hart ◽  
...  
Keyword(s):  
Rna Binding ◽  
Protozoan Parasite ◽  
Telomere Maintenance ◽  
Model Systems ◽  
Quadruplex Dna ◽  
Dna And Rna ◽  
G Quadruplex ◽  
Associated Proteins

In the early-diverging protozoan parasite Plasmodium, few telomere-binding proteins have been identified and several are unique. Plasmodium telomeres, like those of most eukaryotes, contain guanine-rich repeats that can form G-quadruplex structures. In model systems, quadruplex-binding drugs can disrupt telomere maintenance and some quadruplex-binding drugs are potent anti-plasmodial agents. Therefore, telomere-interacting and quadruplex-interacting proteins may offer new targets for anti-malarial therapy. Here, we report that P. falciparum GBP2 is such a protein. It was identified via Proteomics of Isolated Chromatin fragments, applied here for the first time in Plasmodium. In vitro, PfGBP2 binds specifically to G-rich telomere repeats in quadruplex form and it can also bind to G-rich RNA. In vivo, PfGBP2 partially colocalises with the known telomeric protein HP1 but is also found in the cytoplasm, probably due to its affinity for RNA. Consistently, its interactome includes numerous RNA-associated proteins. PfGBP2 is evidently a multifunctional DNA/RNA-binding factor in Plasmodium.

Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo

2005 ◽  
Vol 12 (10) ◽  
pp. 847-854 ◽  
Author(s):  
Katrin Paeschke ◽  
Tomas Simonsson ◽  
Jan Postberg ◽  
Daniela Rhodes ◽  
Hans Joachim Lipps
Keyword(s):  
Binding Proteins ◽  
Quadruplex Dna ◽  
Dna Structures ◽  
G Quadruplex
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