scholarly journals Biosynthesis of the Novel Macrolide Antibiotic Anthracimycin

2015 ◽  
Vol 10 (11) ◽  
pp. 2468-2479 ◽  
Author(s):  
Silke Alt ◽  
Barrie Wilkinson
Keyword(s):  
Macrolide Antibiotic ◽  
The Novel

Analysis of the1H and13C NMR spectra of the novel macrolide antibiotic roxithromycin. Structure and conformation in solution

1990 ◽  
Vol 28 (10) ◽  
pp. 846-855 ◽  
Author(s):  
Josyane Gharbi-Benarous ◽  
Marcel Delaforge ◽  
Isabelle Artaud ◽  
Jean-Pierre Girault
Keyword(s):  
Nmr Spectra ◽  
Macrolide Antibiotic ◽  
The Novel

Disposition and metabolism of the novel macrolide antibiotic CP‐163505 in cattle

1998 ◽  
Vol 21 (2) ◽  
pp. 99-106 ◽  
Author(s):  
M.C. Linhares ◽  
L.F. Harran ◽  
T.J. Strelevitz ◽  
J.W. Gauthier ◽  
M.J. Cole ◽  
...  
Keyword(s):  
Macrolide Antibiotic ◽  
The Novel

Ultrastructural autoradiography of L6 skeletal-muscle cells exposed to a tritiated macrolide antibiotic (LY237216) in vitro

1992 ◽  
Vol 50 (1) ◽  
pp. 612-613
Author(s):  
S.L. White ◽  
C.B. Jensen ◽  
D.D. Giera ◽  
D.A. Laska ◽  
M.N. Novilla ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Quantitative Analysis ◽  
Macrolide Antibiotic ◽  
Circle Method ◽  
Apical Surface ◽  
Polycarbonate Membrane ◽  
L6 Cells ◽  
Low Viscosity ◽  
Erythromycin A

In vitro exposure to LY237216 (9-Deoxo-11-deoxy-9,11-{imino[2-(2-methoxyethoxy)ethylidene]-oxy}-(9S)-erythromycin), a macrolide antibiotic, was found to induce cytoplasmic vacuolation in L6 skeletal muscle myoblast cultures (White, S.L., unpubl). The present study was done to determine, by autoradiographic quantitative analysis, the subcellular distribution of 3H-LY237216 in L6 cells.L6 cells (ATCC, CRL 1458) were cultured to confluency on polycarbonate membrane filters (Millipore Corp., Bedford, MA) in M-199 medium (GIBCO® Labs) with 10% fetal bovine serum. The cells were exposed from the apical surface for 1-hour to unlabelled-compound (0 μCi/ml) or 50 (μCi/ml of 3H-LY237216 at a compound concentration of 0.25 mg/ml. Following a rapid rinse in compound-free growth medium, the cells were slam-frozen against a liquid nitrogen cooled, polished copper block in a CF-100 cryofixation unit (LifeCell Corp., The Woodlands, TX). Specimens were dried in the MDD-C Molecular Distillation Drier (LifeCell Corp.), vapor osmicated and embedded in Spurrs low viscosity resin. Ultrathin sections collected on formvar coated stainless steel grids were counter-stained, then individually mounted on corks. A monolayer of Ilford L4 nuclear emulsion (Polysciences, Inc., Warrington, PA) was placed on the sections, utilizing a modified “loop method”. The emulsions were exposed for 7-weeks in a light-tight box at 4°C. Autoradiographs were developed in Microdol-X developer and examined on a Philips EM410LS transmission electron microscope. Quantitative analysis of compound localization employed the point and circle approach of Williams; incorporating the probability circle method of Salpeter and McHenry.

The novel steroidal glycoside from the dried bulb of Allium Macrostemon Bunge inhibits platelet activation

2010 ◽  
Vol 34 (8) ◽  
pp. S33-S33
Author(s):  
Wenchao Ou ◽  
Haifeng Chen ◽  
Yun Zhong ◽  
Benrong Liu ◽  
Keji Chen
Keyword(s):  
Platelet Activation ◽  
The Novel ◽  
Steroidal Glycoside ◽  
Allium Macrostemon
Sign in / Sign up

Export Citation Format

Share Document