Analysis of the1H and13C NMR spectra of the novel macrolide antibiotic roxithromycin. Structure and conformation in solution

1990 ◽  
Vol 28 (10) ◽  
pp. 846-855 ◽  
Author(s):  
Josyane Gharbi-Benarous ◽  
Marcel Delaforge ◽  
Isabelle Artaud ◽  
Jean-Pierre Girault
Keyword(s):  
Nmr Spectra ◽  
Macrolide Antibiotic ◽  
The Novel

scholarly journals Biosynthesis of the Novel Macrolide Antibiotic Anthracimycin

2015 ◽  
Vol 10 (11) ◽  
pp. 2468-2479 ◽  
Author(s):  
Silke Alt ◽  
Barrie Wilkinson
Keyword(s):  
Macrolide Antibiotic ◽  
The Novel

scholarly journals Synthesis of new condensed coumarin derivatives

2007 ◽  
Vol 5 (1) ◽  
pp. 85-88 ◽  
Author(s):  
Stojadin Dekic ◽  
Vidoslav Dekic ◽  
Branimirka Vucic ◽  
Biljana Dekic ◽  
Milan Dekic
Keyword(s):  
Acid Hydrolysis ◽  
Nmr Spectra ◽  
Proton Nmr ◽  
Catalytic Amount ◽  
The Novel ◽  
Coumarin Derivatives ◽  
Elemental Analyses

Reactions of 4-chloro-2-oxo-2H-chromene-3-carbonitrile (1) with 4-methylpyridin- 2-ylamine (2) and 6-methoxy-benzothiazol-2-ylamine (3) in acetonitrile containing a catalytic amount of triethylamine gave the new coumarin derivatives 7-imino-10-methyl-7H- 5-oxa-7a,12-diaza-benzo[a]anthracen-6-one (4) and 7-imino-10-methoxy-7H-5-oxa-12- thia-7a,13-diaza-indeno[1,2-b]phenanthren-6-one (5) in 52 and 39% yields, respectively. The novel compounds were subjected to acid hydrolysis giving the corresponding oxoderivatives 10-methyl-5-oxa-7a,12-diaza-benzo[a]anthracene-6,7-dione (6) and 10- methoxy-5-oxa-12-thia-7a,13-diaza-indeno[1,2-b]phenanthrene-6,7-dione (7) in 64 and 58% yields, respectively. The structural assignments of the synthesized compounds were based on elemental analyses, IR and proton NMR spectra. .

Selenium coronands. A novel conformational pair

1988 ◽  
Vol 66 (11) ◽  
pp. 2956-2958 ◽  
Author(s):  
B. Mario Pinto ◽  
Blair D. Johnston ◽  
Raymond J. Batchelor ◽  
Frederick W. B. Einstein ◽  
Ian D. Gay
Keyword(s):  
Nmr Spectra ◽  
Crystallographic Analysis ◽  
The Novel ◽  
Torsion Angles ◽  
X Ray ◽  
Structure Formula ◽  
Independent Molecules ◽  
Similar Conformation ◽  
C Nmr

The synthesis and characterization of the novel selenium coronands, 1,3,7,9-tetraselenacyclododecane 1a, 1,3,7,9,13,15-hexaselenacyclooctadecane 2a, the corresponding β-gem-dimethyl derivatives 1b, 2b, and 1,5,9,13-tetraselenacyclohexadecane 3, and 1,5,9,13,17,21-hexaselenacyclotetracosane 4 are described. X-ray crystallographic analysis of 1a reveals three independent molecules that exist in two distinct conformations, one molecule having approximate two-fold symmetry together with two molecules (of similar conformation) each having crystallographic [Formula: see text] symmetry. The conformations are denoted as [3333] or [66]. Whereas one resembles that of cyclododecane and tetrathia-12-crown-4 with respect to torsion angles, the other resembles that of tetraoxa-12-crown-4. The solid state CP-MAS 77Se and 13C nmr spectra are interpreted in light of the crystallographic information. Crystal structure: formula Se4C8H16; fw = 428.05; monoclinic, P21/c; Z = 8; a = 15.823(2) Å, b = 5.534(1) Å, c = 27.962(5) Å, β = 92.26(1)°; V = 2446.6 Å3; T = 200 K; R = 0.027 for 2162 observed data (I ≥ 2.5σ(I)).

scholarly journals A New Bianthracene C-arabinopyranoside from Senna septemtrionalis

2010 ◽  
Vol 5 (5) ◽  
pp. 1934578X1000500
Author(s):  
Gizachew Alemayehu ◽  
Legesse Adane ◽  
Berhanu M. Abegaz
Keyword(s):  
Secondary Metabolites ◽  
Nmr Spectra ◽  
Spectroscopic Analysis ◽  
Stem Bark ◽  
The Novel

Chrysophanol, physcion, emodin, floribundone-1, 5,7′-physcion-fallacinol, and the novel 5,7′-physcion-physcion-10′- C-α-arabinopyranoside were isolated from the stem bark of Senna septemtrionalis. The structures of these secondary metabolites were determined on the basis of spectroscopic analysis, especially from NMR spectra in conjunction with COSY, HMQC, HMBC and TOCSY.

A Facile Synthesis of Selectively Protected Linear Oligoamines

2003 ◽  
Vol 68 (4) ◽  
pp. 744-750 ◽  
Author(s):  
Simona Koščová ◽  
Miloš Buděšínský ◽  
Jana Hodačová
Keyword(s):  
Nmr Spectra ◽  
Preparative Method ◽  
The Novel ◽  
Amino Groups ◽  
Facile Synthesis ◽  
One Pot ◽  
Primary Amino ◽  
Secondary Amino

A convenient multi-gram preparative method for the synthesis of linear oligoamines having the terminal primary amino groups unprotected and the central secondary amino functions protected with tert-butoxycarbonyl groups is presented. At the same time, simple one-pot preparation of the α,ω-bis(trifluoroacetamide) intermediates 2 has been developed. NMR spectra of the novel selectively protected oligoamines are also discussed.

scholarly journals 3-O-(3′-Hydroxytetradecanoyl)lupeol from Sorocea trophoides Inhibits Cruzain

2007 ◽  
Vol 2 (9) ◽  
pp. 1934578X0700200 ◽  
Author(s):  
Lori R. Richter ◽  
Bernhard Vogler ◽  
Ashley F. Penton ◽  
William N. Setzer ◽  
William A. Haber ◽  
...  
Keyword(s):  
Cysteine Protease ◽  
Nmr Spectra ◽  
Stem Bark ◽  
Chloroform Extract ◽  
The Novel ◽  
In Vitro Inhibition

The crude chloroform extract from the stem bark of Sorocea trophoides (Moraceae) showed in-vitro inhibition of the cysteine protease cruzain. Activity-directed fractionation led to isolation of the novel 3- O-(3′-hydroxytetradecanoyl)lupeol as the inhibitory agent. The structure was elucidated by analysis of NMR spectra.

scholarly journals An analysis of the 1H and 13C NMR spectra of the macrolide antibiotic, neoisomidecamycin.

1988 ◽  
Vol 41 (10) ◽  
pp. 1493-1496 ◽  
Author(s):  
HIROKO OGINO ◽  
KATSUYOSHI IWAMATSU ◽  
TOMOKO SHOMURA ◽  
WILLIAM E. HULL ◽  
TAKASHI TSURUOKA ◽  
...  
Keyword(s):  
13C Nmr ◽  
Nmr Spectra ◽  
Macrolide Antibiotic ◽  
13C Nmr Spectra ◽  
1H And 13C Nmr

Ruthenium(II)-Komplexe mit dem neuen Liganden (Oxetanyl-2-methyl)diphenylphosphan / Ruthenium(II) Complexes with the Novel Ligand (Oxetanyl-2-methyl)diphenylphosphine

1992 ◽  
Vol 47 (5) ◽  
pp. 693-696 ◽  
Author(s):  
Ekkehard Lindner ◽  
Andrea Möckel
Keyword(s):  
Nmr Spectra ◽  
Phosphine Ligand ◽  
Chelate Complex ◽  
The Novel ◽  
Basic Properties ◽  
H Nmr

The new ether-phosphine ligand (oxetanyl-2-methyl)diphenylphosphine (1) with strongly basic properties is obtained by reaction of LiPPh2 with 2-chloromethyloxetane. Reaction of 1 with Cl2Ru(PPh3)3 results in the formation of the bis(chelate) complex trans-Cl2Ru(P~O)2 (2). (P∼O = η1-P-coordinated; P~O = η/2-O,P-coordinated). With CO only one Ru-O bond is cleaved to give the monocarbonylruthenium(II) complex trans-Cl2Ru(CO)(P∼O)(P~O) (3). 3 shows fluxional behaviour only at higher temperatures as demonstrated by 31P{1H} NMR spectra.

NMR Spectra of Flavone Di-C-glycosides from Apometzgeria pubescens and the Detection of Rotational Isomerism in 8-C-Hexosylflavones

1987 ◽  
Vol 42 (9-10) ◽  
pp. 1039-1042 ◽  
Author(s):  
Kenneth R. Markham ◽  
Rüdiger Mues ◽  
Marina Stoll ◽  
H. Dietmar Zinsmeister
Keyword(s):  
Nmr Spectra ◽  
Diagnostic Value ◽  
Rotational Isomerism ◽  
The Novel ◽  
C Nmr

1H and 13C NMR spectra are documented for the novel flavone-6,8-di-C-glycosides isolated from the liverwort, Apometzgeria pubescens. The existence of rotational isomerism evident from these spectra is shown to be general for 8-C-monohexosylflavones and of possible diagnostic value.

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