Catalytic Asymmetric Mannich Reaction of α-Fluoronitriles with Ketimines: Enantioselective and Diastereodivergent Construction of Vicinal Tetrasubstituted Stereocenters

Ransheng Ding; Zeus A. De los Santos; Christian Wolf

doi:10.1021/acscatal.8b05164

Catalytic Asymmetric Mannich Reaction of α-Fluoronitriles with Ketimines: Enantioselective and Diastereodivergent Construction of Vicinal Tetrasubstituted Stereocenters

ACS Catalysis ◽

10.1021/acscatal.8b05164 ◽

2019 ◽

Vol 9 (3) ◽

pp. 2169-2176 ◽

Cited By ~ 18

Author(s):

Ransheng Ding ◽

Zeus A. De los Santos ◽

Christian Wolf

Keyword(s):

Mannich Reaction ◽

Catalytic Asymmetric

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Substrate-Controlled Diastereoselectivity Switch in Catalytic Asymmetric Direct Mannich Reaction of Glycine Derivatives with Imines: Fromanti- tosyn-α,β-Diamino Acids

Chemistry - A European Journal ◽

10.1002/chem.200902258 ◽

2010 ◽

Vol 16 (4) ◽

pp. 1153-1157 ◽

Cited By ~ 50

Author(s):

Jorge Hernández-Toribio ◽

Ramón Gómez Arrayás ◽

Juan Carlos Carretero

Keyword(s):

Mannich Reaction ◽

Catalytic Asymmetric ◽

Glycine Derivatives

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Catalytic Asymmetric Mannich Reaction of Isatin-derivedN-Boc Imines with Malononitrile by Bis(imidazolidine)-derived Pincer Rh Complex

ChemistrySelect ◽

10.1002/slct.201701444 ◽

2017 ◽

Vol 2 (24) ◽

pp. 7368-7371 ◽

Cited By ~ 7

Author(s):

Takayoshi Arai ◽

Takuya Tosaka ◽

Satoru Kuwano

Keyword(s):

Mannich Reaction ◽

Catalytic Asymmetric

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Direct Catalytic Asymmetric Mannich Reaction with Dithiomalonates as Excellent Mannich Donors: Organocatalytic Synthesis of (R )-Sitagliptin

Angewandte Chemie International Edition ◽

10.1002/anie.201605167 ◽

2016 ◽

Vol 55 (36) ◽

pp. 10825-10829 ◽

Cited By ~ 32

Author(s):

Han Yong Bae ◽

Mun Jong Kim ◽

Jae Hun Sim ◽

Choong Eui Song

Keyword(s):

Mannich Reaction ◽

Catalytic Asymmetric

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The Direct Catalytic Asymmetric Cross-Mannich Reaction: A Highly Enantioselective Route to 3-Amino Alcohols and α-Amino Acid Derivatives.

ChemInform ◽

10.1002/chin.200432045 ◽

2004 ◽

Vol 35 (32) ◽

Author(s):

Armando Cordova

Keyword(s):

Amino Acid ◽

Mannich Reaction ◽

Amino Alcohols ◽

Amino Acid Derivatives ◽

Catalytic Asymmetric

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Catalytic asymmetric direct Mannich reaction: a powerful tool for the synthesis of α,β-diamino acids

Chemical Society Reviews ◽

10.1039/b820303b ◽

2009 ◽

Vol 38 (7) ◽

pp. 1940 ◽

Cited By ~ 233

Author(s):

Ramón Gómez Arrayás ◽

Juan C. Carretero

Keyword(s):

Mannich Reaction ◽

Catalytic Asymmetric

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ChemInform Abstract: Substrate-Controlled Diastereoselectivity Switch in Catalytic Asymmetric Direct Mannich Reaction of Glycine Derivatives with Imines: From anti- to syn-α,β-Diamino Acids.

ChemInform ◽

10.1002/chin.201022068 ◽

2010 ◽

Vol 41 (22) ◽

pp. no-no

Author(s):

Jorge Hernandez-Toribio ◽

Ramon Gomez Arrayas ◽

Juan Carlos Carretero

Keyword(s):

Mannich Reaction ◽

Catalytic Asymmetric ◽

Glycine Derivatives

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Catalytic Asymmetric Mannich Reaction with N-Carbamoyl Imine Surrogates of Formaldehyde and Glyoxylate

Angewandte Chemie International Edition ◽

10.1002/anie.201707005 ◽

2017 ◽

Vol 56 (44) ◽

pp. 13814-13818 ◽

Cited By ~ 22

Author(s):

Yang'en You ◽

Long Zhang ◽

Linfeng Cui ◽

Xueling Mi ◽

Sanzhong Luo

Keyword(s):

Mannich Reaction ◽

Catalytic Asymmetric

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New Strategic Reactions for Organic Synthesis: Catalytic Asymmetric C−H Activation α to Nitrogen as a Surrogate for the Mannich Reaction

Journal of the American Chemical Society ◽

10.1021/ja0290072 ◽

2003 ◽

Vol 125 (21) ◽

pp. 6462-6468 ◽

Cited By ~ 89

Author(s):

Huw M. L. Davies ◽

Chandrasekar Venkataramani ◽

Tore Hansen ◽

Darrin W. Hopper

Keyword(s):

Organic Synthesis ◽

Mannich Reaction ◽

The Mannich Reaction ◽

Strategic Reactions ◽

Catalytic Asymmetric

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Asymmetric Synthesis of 2-Substituted Hexahydroquinolin-4-ones Using a Pd-Catalyzed Asymmetric Allylic Amination and Intramolecular Mannich Reaction: Catalytic Asymmetric Synthesis of 2-epi-cis-195A

Synthesis ◽

10.1055/s-0030-1260102 ◽

2011 ◽

Vol 2011 (16) ◽

pp. 2540-2548 ◽

Cited By ~ 2

Author(s):

Yasumasa Hamada ◽

Kazumi Kakugawa ◽

Tetsuhiro Nemoto ◽

Yuta Kohno

Keyword(s):

Asymmetric Synthesis ◽

Mannich Reaction ◽

Allylic Amination ◽

Catalytic Asymmetric Synthesis ◽

Catalytic Asymmetric

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ChemInform Abstract: The Direct Catalytic Asymmetric Three-Component Mannich Reaction.

ChemInform ◽

10.1002/chin.200103031 ◽

2001 ◽

Vol 32 (3) ◽

pp. no-no

Author(s):

Benjamin List

Keyword(s):

Mannich Reaction ◽

Catalytic Asymmetric

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