scholarly journals Rational Design of a (S)-Selective-Transaminase for Asymmetric Synthesis of (1S)-1-(1,1′-biphenyl-2-yl)ethanamine

ACS Catalysis ◽  
2016 ◽  
Vol 6 (11) ◽  
pp. 7749-7759 ◽  
Author(s):  
Daniel F. A. R. Dourado ◽  
Stefan Pohle ◽  
Alexandra T. P. Carvalho ◽  
Dharmendra S. Dheeman ◽  
Jill M. Caswell ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Rational Design

Rational Design and Asymmetric Synthesis of Potent and Neurotrophic Ligands for FK506-Binding Proteins (FKBPs)

2014 ◽  
Vol 54 (1) ◽  
pp. 345-348 ◽  
Author(s):  
Sebastian Pomplun ◽  
Yansong Wang ◽  
Alexander Kirschner ◽  
Christian Kozany ◽  
Andreas Bracher ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Rational Design ◽  
Binding Proteins ◽  
Fk506 Binding Proteins

Rational Design of MIL-101(Cr)-Based Catalysts for Asymmetric Synthesis and Biomass Conversion

2017 ◽  
Vol 23 (6) ◽  
pp. 5821-5823 ◽  
Author(s):  
Huixian Yu ◽  
Zhiwei Guo ◽  
Yindi Zang ◽  
Yan Jin ◽  
Tao Shi ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Rational Design ◽  
Biomass Conversion

scholarly journals Engineering of Reductive Aminases for Asymmetric Synthesis of Enantiopure Rasagiline

2021 ◽  
Vol 9 ◽  
Author(s):  
Kai Zhang ◽  
Yuanzhi He ◽  
Jiawei Zhu ◽  
Qi Zhang ◽  
Luyao Tang ◽  
...  
Keyword(s):  
Transition Metal ◽  
Chemical Synthesis ◽  
Asymmetric Synthesis ◽  
Rational Design ◽  
Enantiomeric Excess ◽  
Industrial Applications ◽  
Viable Alternative ◽  
Environmentally Benign ◽  
Secondary Amines ◽  
Metal Catalyzed

Reductive aminases (RedAms) for the stereoselective amination of ketones represent an environmentally benign and economically viable alternative to transition metal–catalyzed asymmetric chemical synthesis. Here, we report two RedAms from Aspergillus calidoustus (AcRedAm) and bacteria (BaRedAm) with NADPH-dependent features. The enzymes can synthesize a set of secondary amines using a broad range of ketone and amine substrates with up to 97% conversion. To synthesize the pharmaceutical ingredient (R)-rasagiline, we engineered AcRedAm through rational design to obtain highly stereoselective mutants. The best mutant Q237A from AcRedAm could synthesize (R)-rasagiline with >99% enantiomeric excess with moderate conversion. The features of AcRedAm and BaRedAm highlight their potential for further study and expand the biocatalytic toolbox for industrial applications.

scholarly journals The Rational Design of Modified Cinchona Alkaloid Catalysts. Application to a New Asymmetric Synthesis of Chiral Chromanes.

ChemInform ◽  
2004 ◽  
Vol 35 (38) ◽  
Author(s):  
Alain Merschaert ◽  
Pieter Delbeke ◽  
Desire Daloze ◽  
Georges Dive
Keyword(s):  
Asymmetric Synthesis ◽  
Rational Design ◽  
Cinchona Alkaloid

scholarly journals The rational design of modified Cinchona alkaloid catalysts. Application to a new asymmetric synthesis of chiral chromanes

2004 ◽  
Vol 45 (24) ◽  
pp. 4697-4701 ◽  
Author(s):  
Alain Merschaert ◽  
Pieter Delbeke ◽  
Désiré Daloze ◽  
Georges Dive
Keyword(s):  
Asymmetric Synthesis ◽  
Rational Design ◽  
Cinchona Alkaloid

Molecular insights on the dynamic stability of peptide nucleic acid functionalized carbon and boron nitride nanotubes

2021 ◽  
Vol 23 (1) ◽  
pp. 219-228
Author(s):  
Nabanita Saikia ◽  
Mohamed Taha ◽  
Ravindra Pandey
Keyword(s):  
Nucleic Acid ◽  
Boron Nitride ◽  
Nucleic Acids ◽  
Dynamic Stability ◽  
Peptide Nucleic Acid ◽  
Rational Design ◽  
Peptide Nucleic Acids ◽  
Boron Nitride Nanotubes ◽  
Molecular Hybrids ◽  
Single Wall Nanotubes

The rational design of self-assembled nanobio-molecular hybrids of peptide nucleic acids with single-wall nanotubes rely on understanding how biomolecules recognize and mediate intermolecular interactions with the nanomaterial's surface.

Optimizing electron density of nickel sulfide electrocatalysts through sulfur vacancy engineering for alkaline hydrogen evolution

2020 ◽  
Vol 8 (35) ◽  
pp. 18207-18214
Author(s):  
Dongbo Jia ◽  
Lili Han ◽  
Ying Li ◽  
Wenjun He ◽  
Caichi Liu ◽  
...  
Keyword(s):  
Hydrogen Evolution ◽  
Electron Density ◽  
Rational Design ◽  
Nickel Sulfide ◽  
Catalytic Performance ◽  
Sulfide Catalysts ◽  
Sulfur Vacancy

A novel, rational design for porous S-vacancy nickel sulfide catalysts with remarkable catalytic performance for alkaline HER.

Rational design of annotine analogues with increased inhibitory activity towards acetylcholinesterase

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
ES Halldorsdottir ◽  
S Oddsson ◽  
AM Einarsdottir ◽  
B Eiriksdottir ◽  
NM Kowal ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Rational Design
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