Rational Design and Asymmetric Synthesis of Potent and Neurotrophic Ligands for FK506-Binding Proteins (FKBPs)

2014 ◽  
Vol 54 (1) ◽  
pp. 345-348 ◽  
Author(s):  
Sebastian Pomplun ◽  
Yansong Wang ◽  
Alexander Kirschner ◽  
Christian Kozany ◽  
Andreas Bracher ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Rational Design ◽  
Binding Proteins ◽  
Fk506 Binding Proteins

scholarly journals Inhibition of FK506 Binding Proteins Reduces  -Synuclein Aggregation and Parkinson's Disease-Like Pathology

2010 ◽  
Vol 30 (7) ◽  
pp. 2454-2463 ◽  
Author(s):  
M. Gerard ◽  
A. Deleersnijder ◽  
V. Daniels ◽  
S. Schreurs ◽  
S. Munck ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Binding Proteins ◽  
Fk506 Binding Proteins

scholarly journals Recombinant Protein Truncation Strategy for Inducing Bactericidal Antibodies to the Macrophage Infectivity Potentiator Protein of Neisseria meningitidis and Circumventing Potential Cross-Reactivity with Human FK506-Binding Proteins

2014 ◽  
Vol 83 (2) ◽  
pp. 730-742 ◽  
Author(s):  
Magdalena K. Bielecka ◽  
Nathalie Devos ◽  
Mélanie Gilbert ◽  
Miao-Chiu Hung ◽  
Vincent Weynants ◽  
...  
Keyword(s):  
Neisseria Meningitidis ◽  
Bactericidal Activity ◽  
Binding Proteins ◽  
Leader Peptide ◽  
Type I ◽  
Globular Domain ◽  
His Tag ◽  
Macrophage Infectivity Potentiator ◽  
Fk506 Binding Proteins ◽  
Macrophage Infectivity

A recombinant macrophage infectivity potentiator (rMIP) protein ofNeisseria meningitidisinduces significant serum bactericidal antibody production in mice and is a candidate meningococcal vaccine antigen. However, bioinformatics analysis of MIP showed some amino acid sequence similarity to human FK506-binding proteins (FKBPs) in residues 166 to 252 located in the globular domain of the protein. To circumvent the potential concern over generating antibodies that could recognize human proteins, we immunized mice with recombinant truncated type I rMIP proteins that lacked the globular domain and the signal leader peptide (LP) signal sequence (amino acids 1 to 22) and contained the His purification tag at either the N or C terminus (C-term). The immunogenicity of truncated rMIP proteins was compared to that of full (i.e., full-length) rMIP proteins (containing the globular domain) with either an N- or C-terminal His tag and with or without the LP sequence. By comparing the functional murine antibody responses to these various constructs, we determined that C-term His truncated rMIP (−LP) delivered in liposomes induced high levels of antibodies that bound to the surface of wild-type but not Δmipmutant meningococci and showed bactericidal activity against homologous type I MIP (median titers of 128 to 256) and heterologous type II and III (median titers of 256 to 512) strains, thereby providing at least 82% serogroup B strain coverage. In contrast, in constructs lacking the LP, placement of the His tag at the N terminus appeared to abrogate bactericidal activity. The strategy used in this study would obviate any potential concerns regarding the use of MIP antigens for inclusion in bacterial vaccines.

Gene expression of FK506-binding proteins 12.6 and 12 during chicken development

2003 ◽  
Vol 136 (2) ◽  
pp. 391-399 ◽  
Author(s):  
Shigenobu Yazawa ◽  
Koji Obata ◽  
Akio Iio ◽  
Masafumi Koide ◽  
Mitsuhiro Yokota ◽  
...  
Keyword(s):  
Gene Expression ◽  
Binding Proteins ◽  
Fk506 Binding Proteins ◽  
Chicken Development

scholarly journals COMPARATIVE ANALYSIS OF FK506-BINDING PROTEINS 51 (FKBP51) AND 52 (FKBP52) IN UTERINE FIBROIDS COMPARED TO NORMAL MYOMETRIUM

2020 ◽  
Vol 114 (3) ◽  
pp. e234
Author(s):  
Erika P. New ◽  
Joung Woul Kim ◽  
A.S.L.I. Ozmen ◽  
Xiaofang Guo ◽  
Ozlem Guzeloglu-Kayisli ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Binding Proteins ◽  
Uterine Fibroids ◽  
Fk506 Binding Proteins

DEVELOPMENTAL EXPRESSION OF FK506 BINDING PROTEINS AND CALCINEURIN IN RAT BRAIN

1995 ◽  
Vol 23 (3) ◽  
pp. 422S-422S ◽  
Author(s):  
ABIGAIL R. CHARTERS ◽  
MASAKAZU KOBAYASHI ◽  
STEVE P. BUTCHER
Keyword(s):  
Rat Brain ◽  
Binding Proteins ◽  
Developmental Expression ◽  
Fk506 Binding Proteins

scholarly journals Genome-wide analyses of genes encoding FK506-binding proteins reveal their involvement in abiotic stress responses in apple

BMC Genomics ◽  
2018 ◽  
Vol 19 (1) ◽  
Author(s):  
Qinglong Dong ◽  
Ke Mao ◽  
Dingyue Duan ◽  
Shuang Zhao ◽  
Yanpeng Wang ◽  
...  
Keyword(s):  
Abiotic Stress ◽  
Stress Responses ◽  
Binding Proteins ◽  
Genome Wide ◽  
Genes Encoding ◽  
Fk506 Binding Proteins

scholarly journals N-terminal and Central Segments of the Type 1 Ryanodine Receptor Mediate Its Interaction with FK506-binding Proteins

2013 ◽  
Vol 288 (22) ◽  
pp. 16073-16084 ◽  
Author(s):  
Tanya Girgenrath ◽  
Mohana Mahalingam ◽  
Bengt Svensson ◽  
Florentin R. Nitu ◽  
Razvan L. Cornea ◽  
...  
Keyword(s):  
Ryanodine Receptor ◽  
Binding Proteins ◽  
Fk506 Binding Proteins
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