scholarly journals Palladium-Catalyzed Carbonylative Cyclization of Amines via γ-C(sp3)–H Activation: Late-Stage Diversification of Amino Acids and Peptides

ACS Catalysis ◽  
2016 ◽  
Vol 6 (10) ◽  
pp. 6868-6882 ◽  
Author(s):  
Elier Hernando ◽  
Julia Villalva ◽  
Ángel Manu Martínez ◽  
Inés Alonso ◽  
Nuria Rodríguez ◽  
...  
Keyword(s):  
Amino Acids ◽  
Late Stage ◽  
Palladium Catalyzed

scholarly journals Late-stage C(sp2)–H and C(sp3)–H glycosylation of C-aryl/alkyl glycopeptides: mechanistic insights and fluorescence labeling

2020 ◽  
Vol 11 (25) ◽  
pp. 6521-6526 ◽  
Author(s):  
Jun Wu ◽  
Nikolaos Kaplaneris ◽  
Shaofei Ni ◽  
Felix Kaltenhäuser ◽  
Lutz Ackermann
Keyword(s):  
Amino Acids ◽  
Late Stage ◽  
Fluorescence Labeling ◽  
Palladium Catalyzed ◽  
Peptide Isosteres

C–H glycosylations of complex amino acids and peptides were accomplished through the assistance of triazole peptide-isosteres. The palladium-catalyzed glycosylation provided access to complex C-glycosides and fluorescent-labeled glycoamino acids.

Sequential C-Selective Difluoromethylation/Pd-Catalyzed Decarboxylative Protonation: An Efficient Access to Tertiary Difluoromethylated Scaffolds

2019 ◽  
Author(s):  
Nicolas Duchemin ◽  
Roberto Buccafusca ◽  
Marc Daumas ◽  
Vincent Ferey ◽  
Stellios Arseniyadis
Keyword(s):  
Drug Development ◽  
Late Stage ◽  
Efficient Access ◽  
Palladium Catalyzed ◽  
General Method

We report here a general method that allows a highly straightforward access to tertiary difluoromethylated compounds. The strategy relies on a two-step sequence featuring a C-selective electrophilic difluoromethylation and an unprecedented palladium-catalyzed decarboxylative protonation. Considering the generality of the method and the attractive properties offered by the difluoromethyl group, this approach provides a valuable tool for late-stage functionalization and drug development.<br>

scholarly journals Insights into genome recoding from the mechanism of a classic +1-frameshifting tRNA

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Howard Gamper ◽  
Haixing Li ◽  
Isao Masuda ◽  
D. Miklos Robkis ◽  
Thomas Christian ◽  
...  
Keyword(s):  
Amino Acids ◽  
Conformational Change ◽  
Molecular Mechanism ◽  
Late Stage ◽  
Anticodon Loop ◽  
Pairing Mechanism ◽  
Extra Nucleotide ◽  
In Cells

AbstractWhile genome recoding using quadruplet codons to incorporate non-proteinogenic amino acids is attractive for biotechnology and bioengineering purposes, the mechanism through which such codons are translated is poorly understood. Here we investigate translation of quadruplet codons by a +1-frameshifting tRNA, SufB2, that contains an extra nucleotide in its anticodon loop. Natural post-transcriptional modification of SufB2 in cells prevents it from frameshifting using a quadruplet-pairing mechanism such that it preferentially employs a triplet-slippage mechanism. We show that SufB2 uses triplet anticodon-codon pairing in the 0-frame to initially decode the quadruplet codon, but subsequently shifts to the +1-frame during tRNA-mRNA translocation. SufB2 frameshifting involves perturbation of an essential ribosome conformational change that facilitates tRNA-mRNA movements at a late stage of the translocation reaction. Our results provide a molecular mechanism for SufB2-induced +1 frameshifting and suggest that engineering of a specific ribosome conformational change can improve the efficiency of genome recoding.

scholarly journals Plasma albumin synthesis during neonatal development of the rat

1967 ◽  
Vol 102 (3) ◽  
pp. 760-762 ◽  
Author(s):  
R. W. Wise ◽  
I. T. Oliver
Keyword(s):  
Amino Acids ◽  
Specific Antibody ◽  
Late Stage ◽  
Normal Adult ◽  
Albumin Synthesis ◽  
Plasma Albumin ◽  
Pregnant Rat ◽  
Liver Slices ◽  
Parenchymal Cells ◽  
Very High

1. Liver slices were incubated with (14)C-labelled amino acids. Albumin was isolated from the slices by precipitation with specific antibody and the incorporated radioactivity measured. 2. The rate of synthesis was seen to be equal in liver slices from adult and late-stage foetal rats. 3. Synthesis was very high in the pregnant rat (three times the normal adult value) and in the 5-15-day post-natal rat (twice the normal adult value). 4. The post-natal increase may be due to the disappearance of haemopoietic tissue and its replacement by active parenchymal cells.

scholarly journals Palladium-Catalyzed Late-Stage Direct Arene Cyanation

Chem ◽  
2019 ◽  
Vol 5 (1) ◽  
pp. 97-107 ◽  
Author(s):  
Da Zhao ◽  
Peng Xu ◽  
Tobias Ritter
Keyword(s):  
Late Stage ◽  
Palladium Catalyzed

Palladium-Catalyzed Amidocarbonylation—A New, Efficient Synthesis ofN-Acyl Amino Acids

1997 ◽  
Vol 36 (1314) ◽  
pp. 1494-1496 ◽  
Author(s):  
Matthias Beller ◽  
Markus Eckert ◽  
Frank Vollmüller ◽  
Sandra Bogdanovic ◽  
Holger Geissler
Keyword(s):  
Amino Acids ◽  
Efficient Synthesis ◽  
Palladium Catalyzed
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