Hydrophilic Polymer-Brush Functional Fluorescent Nanoparticles to Suppress Nonspecific Interactions and Enhance Quantum Yield for Targeted Cell Imaging

2020 ◽  
Vol 2 (6) ◽  
pp. 2238-2245 ◽  
Author(s):  
Yiting Li ◽  
Xiaoping Qian ◽  
Xinliu Tan ◽  
Xinghua Liu ◽  
Yang Li ◽  
...  
Keyword(s):  
Quantum Yield ◽  
Cell Imaging ◽  
Polymer Brush ◽  
Fluorescent Nanoparticles ◽  
Hydrophilic Polymer ◽  
Nonspecific Interactions

scholarly journals Ultrasmall Organic Nanoparticles with Aggregation-Induced Emission and Enhanced Quantum Yield for Fluorescence Cell Imaging

2016 ◽  
Vol 88 (15) ◽  
pp. 7853-7857 ◽  
Author(s):  
Suying Xu ◽  
Xilin Bai ◽  
Jingwen Ma ◽  
Minmin Xu ◽  
Gaofei Hu ◽  
...  
Keyword(s):  
Quantum Yield ◽  
Cell Imaging ◽  
Organic Nanoparticles ◽  
Aggregation Induced Emission

Redox‐responsive Fluorescent Nanoparticles Based on Diselenide‐containing AIEgens for Cell Imaging and Selective Cancer Therapy

2018 ◽  
Vol 14 (10) ◽  
pp. 1745-1753 ◽  
Author(s):  
Wenkun Han ◽  
Song Zhang ◽  
Jingyu Qian ◽  
Jianxu Zhang ◽  
Xuanhang Wang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cell Imaging ◽  
Fluorescent Nanoparticles ◽  
Redox Responsive

Role of Aqueous-Phase Calcination in Synthesis of Ultra-Stable Dye-Embedded Fluorescent Nanoparticles for Cellular Probing

2021 ◽  
pp. 000370282110275
Author(s):  
Rachel Rex ◽  
Soumik Siddhanta ◽  
Ishan Barman
Keyword(s):  
Silica Nanoparticles ◽  
Cell Imaging ◽  
Fluorescent Dyes ◽  
Aqueous Media ◽  
Clinical Diagnostics ◽  
Live Cell ◽  
Metal Nanoparticle ◽  
Superior Performance ◽  
Fluorescent Nanoparticles

Fluorescence imaging is a major driver of discovery in biology, and an invaluable asset in clinical diagnostics. To overcome quenching limitations of conventional fluorescent dyes and further improve intensity, nanoparticle-based constructs have been the subject of intense investigation, and within this realm, dye-doped silica-coated nanoparticles have garnered significant attention. Despite their growing popularity in research, fluorescent silica nanoparticles suffer from a significant flaw. The degradation of these nanoparticles in biological media by hydrolytic dissolution is underreported, leading to serious misinterpretations, and limiting their applicability for live cell and in vivo imaging. Here, the development of an ultra-stable, dye-embedded, silica-coated metal nanoparticle is reported, and its superior performance in long-term live cell imaging is demonstrated. While conventional dye-doped silica nanoparticles begin to degrade within an hour in aqueous media, by leveraging a modified liquid calcination process, this new construct is shown to be stable for at least 24 h. The stability of this metal-enhanced fluorescent probe in biologically relevant temperatures and media, and its demonstrated utility for cell imaging, paves the way for its future adoption in biomedical research.

Silica-Coated Magnetite Nanoparticles Carrying a High-Density Polymer Brush Shell of Hydrophilic Polymer

2018 ◽  
Vol 39 (13) ◽  
pp. 1800226 ◽  
Author(s):  
Yingying Cai ◽  
Wentao Peng ◽  
Serhiy Demeshko ◽  
Jia Tian ◽  
Philipp Vana
Keyword(s):  
Magnetite Nanoparticles ◽  
Polymer Brush ◽  
High Density ◽  
Hydrophilic Polymer

A polymerizable aggregation-induced emission dye for fluorescent nanoparticles: synthesis, molecular structure and application in cell imaging

2019 ◽  
Vol 10 (17) ◽  
pp. 2162-2169 ◽  
Author(s):  
Zengfang Huang ◽  
Runze Wang ◽  
Yali Chen ◽  
Xiaobo Liu ◽  
Ke Wang ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Cell Imaging ◽  
Raft Polymerization ◽  
Fluorescent Nanoparticles ◽  
Aggregation Induced Emission ◽  
Fluorescent Polymers ◽  
Nanoparticles Synthesis

This work reports the fabrication of a novel polymerizable AIE dye and its amphiphilic PEG-TS fluorescent polymers via RAFT polymerization, which were attractive for the application in cell imaging.

Bright red fluorescent conjugated polymer nanoparticles with dibenzopyran as electron donor for cell imaging

2017 ◽  
Vol 9 (21) ◽  
pp. 3255-3259 ◽  
Author(s):  
Mengyue Fan ◽  
Yuanyuan Zhou ◽  
Yijing Guo ◽  
Jinsheng Song ◽  
Xinrui Duan
Keyword(s):  
Quantum Yield ◽  
Electron Donor ◽  
Conjugated Polymer ◽  
Cell Imaging ◽  
Polymer Nanoparticles ◽  
Mass Ratio ◽  
Conjugated Polymer Nanoparticles

Red fluorescent Conjugated Polymer Nanoparticles (CPNs) were synthesized via widely used CPs: surfactant mass ratio (1 : 2) with the quantum yield as high as 51.8% for cell imaging.

scholarly journals Facile fabrication of AIE/AIEE-active fluorescent nanoparticles based on barbituric for cell imaging applications

RSC Advances ◽  
2017 ◽  
Vol 7 (48) ◽  
pp. 30229-30241 ◽  
Author(s):  
Kai Li ◽  
Yang Zhang ◽  
Bing Qiao ◽  
Furong Tao ◽  
Tianduo Li ◽  
...  
Keyword(s):  
Optical Properties ◽  
Cell Imaging ◽  
Fluorescent Nanoparticles ◽  
Facile Fabrication

Compounds 1–4 were synthesized, and the optical properties and mechanisms were investigated. Compound 4 was applied to the cell imaging.

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