pH-Sensitive Theranostic Nanoparticles for Targeting Bacteria with Fluorescence Imaging and Dual-Modal Antimicrobial Therapy

2018 ◽  
Vol 1 (11) ◽  
pp. 6187-6196 ◽  
Author(s):  
Peng Liu ◽  
Li Qun Xu ◽  
Gang Xu ◽  
Dicky Pranantyo ◽  
Koon-Gee Neoh ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Antimicrobial Therapy ◽  
Ph Sensitive ◽  
Theranostic Nanoparticles

Double pH-sensitive Nanotheranostics of Polypeptide Nanoparticle-Encapsulated BODIPY with Both NIR Activated Fluorescence and Enhanced Photodynamic Therapy

2021 ◽  
Author(s):  
Huiping Dang ◽  
Quan Cheng ◽  
Youliang Tian ◽  
Changchang Teng ◽  
Kai Xie ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Fluorescence Imaging ◽  
Intelligent Systems ◽  
Ph Sensitive ◽  
Nir Fluorescence

To achieve accurate fluorescence imaging-guided cancer therapy, intelligent systems with specific responsiveness to the tumor microenvironment need to be designed. Here, we have achieved both enhanced NIR fluorescence and photodynamic...

The use of pH-sensitive functional selenium nanoparticles shows enhanced in vivo VEGF-siRNA silencing and fluorescence imaging

Nanoscale ◽  
2014 ◽  
Vol 6 (15) ◽  
pp. 9279-9292 ◽  
Author(s):  
Qianqian Yu ◽  
Yanan Liu ◽  
Chengwen Cao ◽  
Fangling Le ◽  
Xiuying Qin ◽  
...  
Keyword(s):  
Side Effects ◽  
Gene Silencing ◽  
Fluorescence Imaging ◽  
Delivery System ◽  
Ph Sensitive ◽  
Selenium Nanoparticles ◽  
Vegf Gene ◽  
Sirna Silencing

The pH-sensitive delivery system G2/PAH-Cit/SeNPs@siRNA enhances anti-tumor effects through VEGF gene silencing and reduces angiogenesis, with no side effects in organs.

Gold embedded chitosan nanoparticles with cell membrane mimetic polymer coating for pH-sensitive controlled drug release and cellular fluorescence imaging

2020 ◽  
pp. 088532822095259
Author(s):  
Ke Ma ◽  
Yongbin Cheng ◽  
Xinran Wei ◽  
Daijun Chen ◽  
Xiaoli Zhao ◽  
...  
Keyword(s):  
Drug Release ◽  
Fluorescence Imaging ◽  
Colloidal Stability ◽  
Drug Loading ◽  
Tumor Therapy ◽  
Chitosan Nanoparticles ◽  
Fluorescence Emission ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
One Pot

In this work, gold embedded chitosan nanoparticles (Au@CS NPs) were fabricated by a one-pot method. The benzaldehyde-terminated poly[(2-methacryloyloxy) ethyl phosphorylcholine] (PMPC) was applied to modification of the gold doped chitosan nanoparticles. The obtained Au@CS-PMPC NPs had the diameter of 135 nm with a narrow distribution. The size of the Au@CS-PMPC NPs, as well as the size of the embedded gold NPs, might be well-controlled by adjusting the feeding ratio between chitosan and HAuCl4. Furthermore, the Au@CS-PMPC NPs showed increased colloidal stability, high drug loading content, pH-responsive drug release, excellent biocompatibility and bright fluorescence emission. The results demonstrated that Au@CS-PMPC NPs showed a great potential for tumor therapy via the combination advantages of pH-sensitive controlled drug release and cellular fluorescence imaging.

Two-photon AIE probe conjugated theranostic nanoparticles for tumor bioimaging and pH-sensitive drug delivery

Nano Research ◽  
2019 ◽  
Vol 12 (7) ◽  
pp. 1703-1712 ◽  
Author(s):  
Boxuan Ma ◽  
Weihua Zhuang ◽  
Haiyang He ◽  
Xin Su ◽  
Tao Yu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive ◽  
Two Photon ◽  
Theranostic Nanoparticles

scholarly journals Supported core–shell nanobiosensors for quantitative fluorescence imaging of extracellular pH

2014 ◽  
Vol 50 (89) ◽  
pp. 13746-13749 ◽  
Author(s):  
Jérémie Asselin ◽  
Carl Roy ◽  
Denis Boudreau ◽  
Younès Messaddeq ◽  
Rihab Bouchareb ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Fluorescence Imaging ◽  
Ph Sensitive ◽  
Extracellular Ph ◽  
Live Cells ◽  
Core Shell ◽  
Spatially Resolved ◽  
Quantitative Fluorescence ◽  
Silica Substrates

“Click” chemistry was used to functionalize silica substrates with pH-sensitive nanoparticles, thus producing uniform and highly luminescent ion-sensitive surfaces for quantitative and spatially-resolved extracellular measurements on live cells.

scholarly journals The yeast peroxisomal adenine nucleotide transporter: characterization of two transport modes and involvement in ΔpH formation across peroxisomal membranes

2004 ◽  
Vol 381 (3) ◽  
pp. 581-585 ◽  
Author(s):  
Francesco M. LASORSA ◽  
Pasquale SCARCIA ◽  
Ralf ERDMANN ◽  
Ferdinando PALMIERI ◽  
Hanspeter ROTTENSTEINER ◽  
...  
Keyword(s):  
Green Fluorescent Protein ◽  
Fluorescence Imaging ◽  
Fluorescent Protein ◽  
Adenine Nucleotide ◽  
Ph Sensitive ◽  
Peroxisomal Membrane ◽  
Transport Modes ◽  
Proton Movement ◽  
Green Fluorescent

The yeast peroxisomal adenine nucleotide carrier, Ant1p, was shown to catalyse unidirectional transport in addition to exchange of substrates. In both transport modes, proton movement occurs. Nucleotide hetero-exchange is H+-compensated and electroneutral. Furthermore, microscopic fluorescence imaging of a pH-sensitive green fluorescent protein targeted to peroxisomes shows that Ant1p is involved in the formation of a ΔpH across the peroxisomal membrane, acidic inside.

scholarly journals pH-Sensitive self-assembling nanoparticles for tumor near-infrared fluorescence imaging and chemo–photodynamic combination therapy

Nanoscale ◽  
2016 ◽  
Vol 8 (1) ◽  
pp. 104-116 ◽  
Author(s):  
Wenxiu Hou ◽  
Xin Zhao ◽  
Xiaoqing Qian ◽  
Fei Pan ◽  
Chunlei Zhang ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Fluorescence Imaging ◽  
Combination Treatment ◽  
Near Infrared ◽  
Ph Sensitive ◽  
Near Infrared Fluorescence ◽  
Self Assembling ◽  
Near Infrared Fluorescence Imaging

pH-Sensitive self-assembling anti-tumor prodrug nanoparticles for the diagnosis and chemo-photodynamic combination treatment of tumor.

Self-assembly of BODIPY based pH-sensitive near-infrared polymeric micelles for drug controlled delivery and fluorescence imaging applications

Nanoscale ◽  
2015 ◽  
Vol 7 (39) ◽  
pp. 16399-16416 ◽  
Author(s):  
Xiaodong Liu ◽  
Bizheng Chen ◽  
Xiaojun Li ◽  
Lifen Zhang ◽  
Yujie Xu ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Self Assembly ◽  
Near Infrared ◽  
Polymeric Micelles ◽  
Ph Sensitive ◽  
Controlled Delivery
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